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1992 Fiscal Year Final Research Report Summary

AMINERGIC MODULATION MECHANISMS OF THE CENTRAL AMINERGIC NEURON SYSTEM.

Research Project

Project/Area Number 03670023
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 神経解剖学
Research InstitutionSHIGA UNIVERSITY OF MEDICAL SCIENCE

Principal Investigator

MAEDA Toshihiro  SHIGA UNIVERSITY OF MEDICAL SCIENCE, FACULTY OF MEDICINE, PROFESSOR, 医学部, 教授 (50028388)

Co-Investigator(Kenkyū-buntansha) ARAI Ryohachi  SHIGA UNIVERSITY OF MEDICAL SCIENCE, FACULY OF MEDICINE, ASSISTANT, 医学部, 助手 (20159487)
FUJIMIYA Mineko  SHIGA UNIVERSITY OF MEDICAL SCIENCE, FACULY OF MEDICINE, ASSISTANT, 医学部, 助手 (10199359)
Project Period (FY) 1991 – 1992
KeywordsLocus coeruleus / Noradrenaline / Aminergic-aminergic circuit
Research Abstract

The central aminergic neuron generally shows a state-dependent activity associated with various stages of sleep or wakefulness. It is likely that aminergic-aminergic neural circuits underlie the mechanisms of the state- dependent correlation of aminergic neurons. The aime of the present study is to examine the aminergic-aminergic neural circuits in detail using noradrenergic neurons in the locus coeruleus of adult brain as well as in developing stage.
Results: 1) Dopaminergic input originates from A_<13> of the hypothalamus. 2) Noradrenergic input originates from A_<1,2> of the medulla oblongata. 3) Adrenergic input originates from C_1 of the medulla oblongata. 4) Serotonergic input originates from the mesensephalon and pons. 5) Adrenergic input makes synapse of large asymmetrical type with noradrenaline-containing neuron. 6) Dopaminergic input makes synapse of asymmetrical type and of symmetrical type with aminergic and non-aminergic neurons, respectively. 7) Serotonergic input makes s … More ynapse of symmetrical type with non-aminergic neuron.
In summary, the activity of noradrenergic neuron of the locus coeruleus may be powerfully modulated with dopaminergic neuron originating from the hypothalamus as well as with adrenergic neuron originating from the medulla oblongata, correlating with autonomic information at both the higher and lower levels. It was also suggested that there are different aminergic-aminergic circuits for each amine-containing neuron group, because the aminergic circuit revealed in the present study was shown to be specific to the locus coeruleus.
Concerning the modulating mechanisms of aminergic neuron in the developing brain, transient serotonergic innervation in the cerebral cortex occurring in early stage has been studied. We clarified that the young serotonergic neuron densely innervates the developing sensory cortices with a close correlation with sensory input and ceases its cortical projection immediately after differentiation of cortical sensory receptive neuron and that 40 %of the serotonergic projection neurons to the cortex lose their cortical projection during the maturation of brain but do not die. Aminergic input to the developing aminergic neuron is now a big target of our interest. Less

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 前田 敏博: "Monoaminergic interaction in the central nervous system:a morphological analysis in the locus coeruleus of the rat." Copmarative Biochemistry and Physiology. 98. 193-202 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 黄 亭然: "Signlficant non-serotonergic raphe projection to the visual cortex of the rat.An immunohistochemical study combined with retrograde tracing." Journal fur Hirnforchung. 32. 707-714 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 黄 亭然: "Investigations of Origins of serotonergic projection to developing rat visual cortex:a combined retrograde tracing and immunohistochemical study." Brain Research Bulletin. 27. 675-684 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中沢 みどり: "Transient patterns of serotonergic innervation in the rat visual cortex:normal development and effects of neonatal enucleation." Developmental Brain Research. 66. 77-90 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 新井 良八: "Combined use of silver staining of the retrograde tracer WGAapoHRP-Au and Pre-embedding immunocytochemistry for electron microscopy:demonstration of terminals in synaptic contact with striatal neurous projecting to the substantia nigra in the rat." Journal of Histochemistry and Cytochemistry. 40. 889-892 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小島 保二: "Possible mechanisms in dopaminergic transmission that vary with brain regions as revealed by elecron-immunohistochemistry.In:Recent advances in cellular and molecular biology,Wegmann,R.J.and Wegmann,M.A.(eds)" Peeters Press,Lesuven, 15 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 前田 敏博: "Monoamine oxidase.In:Electron microscopic cytochemistry and immuno cytochemistry in biomedicine,Ogawa,K.and Barka.T(eds)" CRC Press,Boca Raton, 5 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Koh,T., Nakazawa,M., Kani,K. and Maeda,T.: "Significant non-serotonergic raphe projection to the visual cortex of the rat. An immunohistochemical study combined with retrograde tracing." J. Hirnf.32. 707-714 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koh,T., Nazawa,M., Kani,K. and Maeda,T.: "Investigations of Origins of serotonergic projection to developing rat visual cortex: a combined retrograde tracing and immunohistochemical study." Brain Res. Bull.27. 675-684 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maeda,T.,Kojima,Y.,Arai,R.,Fujimiya,M.,Kimura,H. and Gerrard,M.: "Monoaminergic interaction in the central nervous system: a morphological analysis in the locus coeruleus of the rat." Comp.Biochem.Physuol.98. 193-202 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Arai,R., Kojima,Y., Geffard,M., Kitahama,K. and maeda,T.: "Combined use of silver staining of the retrograde tracer WGAapoHRP-Au and pre-embedding immunocytochemistry for electron microscopy: demonstration of terminals in synaptic contact with striatal neurons projecting to the substantia nigra in the rat." J.Histochem.Cytochem.40. 889-892 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kojima,Y., Kitahama,K., Geffard,M. and Maeda,T.: "Possible mechanisms in dopaminergic transmission that vary with brain regions as revealed by electron-immunohistochemistry." Recent advances in cellular and molecular biology, Wegmann,R.J. and Wegmann,M.A.(eds) Peeters Press,Leuven. vol.3. 77-83 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maeda,T.:"Monoamine oxidase." Electron microscopic cytochemistry and immunocytochemistry in biomedicine, Ogawa,K. and Barka,T. (eds.) CRC Press, Boca Raton. 84-88 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakazawa,M., Koh,T., Kani,K. and Maeda,T.: "Transient patterns of serotonergic innervation in the rat visual cortex: normal development and effects of neonatal enucleation." Dev. Brain Res.66. 77-90 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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