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1993 Fiscal Year Final Research Report Summary

Mechanism of primary biliary cirrhosis and free radicals

Research Project

Project/Area Number 03670342
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionAsahikawa Medica College

Principal Investigator

SEKIYA Chihiro  Asahikawa Med.Col., Internal Medicine III, Lecturer, 医学部, 講師 (30109384)

Co-Investigator(Kenkyū-buntansha) TANIGUCHI Naoyuki  Osaska University Med. School, Biochemistry, Professor, 医学部, 教授 (90002188)
ONO Minoru  Asahikawa Med.Col., Internal Medicine III, Assistant Professor, 医学部, 助手 (60185650)
Project Period (FY) 1991 – 1993
Keywordsprimary biliary cirrhosis / free radicals / manganese-superoxide dismutase
Research Abstract

Serum manganese-superoxide dismutase (Mn-SOD) was determined in patients with various liver diseases with an enzyme-linked immunosorbent assay using a specific monoclonal antibody.
The serum Mn-SOD level in patients with primary biliary cirrhosis (PBC) was significantly increased compared with those of other liver diseases, including chronic viral hepatitis, liver cirrhosis, autoimmune hepatitis, obstructive jaundice, fatty liver and idiopathic portal hypertension. Administration of ursodeoxycholic acid caused the significant decrease of serum Mn-SOD level in PBC patients. Immunostaining of a liver biopsy specimen from the patients with PBC revealed increased expression of the enzyme protein in damaged hepatocytes and degenerated epithelial cells of interlobular bile ducts.

  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Ono M: "Elevated level of serum Mn-superoxide dismutasse in patients with primarybiliary cirrhosis:Possible involvement of free radicals in the pathogenesis in primary biliary cirrhosis." J Lab Clin Med. 118. 476-483 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大平 基之: "原発性胆汁性肝硬変症とmanganese-superoxide dismutase" 日本消化器病学会雑誌. 89. 1474 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大平 基之: "PBC患者における血清Mn-SOD:UDCA投与による変動" 肝臓. 33. 811 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ono M: "Induction of Mn-superoxide dismutase by tumor necrosis factor,interleukin-1 and interleukin-6 in human hepatoma cells." Biochem Biophys Res Commun. 182. 1100-1107 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大平 基之: "肝臓病up date肝炎のA型からG型まで" 中外医学社, 6 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] ONO M.: "Elevated level of serum Mn-supweoxide dismutase in patients with primary biliary cirrhosis : Possible involvement of free radicals in the pathogenesis in primary biliary cirrhosis." J Lab Clin Med. 118. 476-483 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] OHHIRA M.: "Primary biliary cirrhosis and manganese-superoxide dismutase." Jpn J Gastroenterol. 89. 1474 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] OHHIRA M.: "Serum Mn-SOD levels in primary biliary cirrhosis : Effects of UDCA administration." Acta Hepatol Jpn. 33. 811 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] ONO M.: "Induction of Mn-superoxide dismutase by tumor necrosis factor, interleukin-1 and interleukin-6 in human hepatoma cells." Biochem Biophys Res Commum. 182. 1100-1107 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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