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1992 Fiscal Year Final Research Report Summary

Effect of chemotactic factor on pulmonary vascular permeability

Research Project

Project/Area Number 03670396
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionSHINSHU UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

YOSHIMURA Kazuhiko  Shinshu Univ., Assistant Prof., 医学部附属心脈管病研究施設, 講師 (70174985)

Co-Investigator(Kenkyū-buntansha) KUBO Keishi  Shinshu Univ., Assistant Prof., 医学部, 講師 (80143965)
KOBAYASHI Toshio  Shinshu Univ., Assistant Prof., 医学部附属病院, 講師 (80020775)
HANDA Kenjiro  Shinshu Univ., Associate Prof., 医学部, 助教授 (70020724)
Project Period (FY) 1991 – 1992
Keywordschemotactic factor / leukotriene B4 / polymorphonuclear leukocyte / pulmonary vascular permeability / filtration coefficient / isolated perfused lungs / wet to dry lung weight ratio / pulmonary edema
Research Abstract

The effects of exogenous LTB4 on the pulmonary microvascular perme-ability and the roles of polymorphonuclear leukocytes (PMNs), cyclooxy-genase products of arachidonic acid and neutrophil elastase in the microvascular response to LTB4 in the isolated non-blood perfused rabbit lungs were studied. We observed that LTB4 increased filtration coefficient (Kf) and wet to dry lung weight ratio (W/D ratio) in the presence of PMNs in the perfusate. Neither LTB4 alone nor PMNs alone produced changes in Kf and W/D ratio. Indomethacin failed to inhibit the LTB4-induced increases in Kf and W/D ratio. Neutrophil elastase inhibitor effectively inhibited the LTB4-induced lung injury. These results suggest that LTB4 produces lung injury which is dependent on neutrophil elastase derived from PMNs but not on the cyclooxygenase pathway of arachidonic acid metabolism.

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Yoshimura K.: "Leukotriene B4 increases microvascular perweability in isolated perfused rabbit lungs:role of polymorphounclear leuko cytes and effects of indomethaum" J.Appl.Physiol.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshimura K.: "Role of nectrophil elastase in leukotriene B4-induced encreme in pulmonary micro vascular permeability." Am.Rev.Respir.Dis(suppl.). 145. A605 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshimura K., Nakagawa S., Koyama S., Kobayashi T., and Homma T: "Leukotriene B4 increases microvasular permeability in isolated perfused rabbit lungs: role of polymorphonuclear leukocytes and effect of indomethacin." J. Appl. Physiol.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshimura K., Nakagawa S., Koyama S., Kobayashi T., Homma T: "Role of neutrophil elastase in leukotriene B4-induced increase in pulmonary microvascular permeability." Am. Rev. Respir. Dis. (suppl.) 145. A605 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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