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1993 Fiscal Year Final Research Report Summary

Immunohistochemical Staining of Ki-67 Colorectal Carcinoma

Research Project

Project/Area Number 03670615
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionMie University

Principal Investigator

SUZUKI Hiroshi  Mie University, Faculty of Medicine, Professor, 医学部, 教授 (20004632)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Koichi  Mie University, University Hospital, Assisutant Professor, 医学部附属病院, 講師 (80024694)
Project Period (FY) 1991 – 1993
KeywordsColorectal Cancer / Oncoprotein / Ki-67 Antibody / Immunohistochemikal Staining
Research Abstract

Ki-67 labeling index of 58 colorectal carcinomas and 10 normal mucosa samples was determined by the use of an immunohistochemical staining technique. The Ki-67 labeling index in colorectal carcinomas ranged from 15.7 to 63.3% (mean (〕SY.+-.〔) SD of 38.5 (〕SY.+-.〔) 10.5) and was significantly higher than the index for normal colon mucosa (mean (〕SY.+-.〔) SD of 14.1 (〕SY.+-.〔) 2.8). The mean Ki-67 labeling index was significantly higher in Dukes' B and Dukes' C tumors than in Dukes' A tumors, but the index did not correlate between the Ki-67 labeling index of the tumor and lymph node ivolvement. The present study disclosed that the Ki-67 labeling index correlated with local invasion of colorectal carcinoma, but not with metastasis of the tumor.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 鈴木 宏志: "Expression of c-myc oncoprotein p62 in normal colon mucosa and colorectal neoplasmas:An immunohistochemical study" Digestive Surgery. 8. 19-21 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 寺邊 政宏: "大腸癌におけるKi-67標識率(Ki-67 score)と臨床病理学的進行度の関連についての研究" 日本大腸肛門病学会雑誌. 45. 11-16 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 鈴木 宏志: "大腸癌におけるKi-67標識率と予後との関連" 日本大腸肛門病学会雑誌. 45. 851-854 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 鈴木 宏志: "Ki-67 antibody labeling index in colorectal cancer" Journal of Clinical Gastroenterology. 15. 317-320 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松本 好市: "Lack of prognostic value of immunoreactivity for p62 oncoprotein in colorectal carcinoma" International Journal of Colorectal Disease. 8. 103-105 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroshi Suzuki, Tsutomu Miura, Koichi Matsmoto, Naoto Ishijima: "Expression of c-myc oncoprotein p62 in normal colon mucosa and colorectal neoplasms : an immunohistochemical study" Digetive Surgery. 8. 19-21 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masahiro Terabe: "Ki-67 score in colorectal carcinomal : An immunohistochemical study" Journal of Japan Society of Colo-proctology. 45. 11-16 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroshi Suzuki, Koichi Matsumoto, Junji Yamamoto, Masahiro Terabe, Tatsushi Kitagawa, Nobuhito Sugihira, Midori Noji, Toyoji Tada, Akira Koide: "Ki67 labeling index and survival of the patients with colorectal carccinoma" Journal of Japan Society of Colo-proctology. 45. 851-854 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroshi Suzuki, Koichi Matsumoto, Masahiro Terabe: "Ki-67 antibody labeling index in colorectal carcinoma" Journal of Clinical Gastroenterology. 15. 317-320 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koichi Matsumoto, Junji Yamamoto, Tsutomu Miura: "Lack of prognostic value of immunoreactivity for 21 oncoprotein in colorectal carcinoma" International Journal of Coloretal Disease. 8. 103-105 (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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