• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1993 Fiscal Year Final Research Report Summary

Effects of Doxorubicin or OK-432 on Cancer cells during liver regeneration after two-thirds hepatectomy

Research Project

Project/Area Number 03670630
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKyusyu University

Principal Investigator

MATSUYAMA Takashi  Kyusyu Univ.Surgery II, Assistant Prof., 医学部, 講師 (00157348)

Co-Investigator(Kenkyū-buntansha) YANAGA Katsuhiko  Kyusyu Univ.Surgery II, Assistant Prof., 医学部, 講師 (70220176)
Project Period (FY) 1991 – 1993
Keywordsliver tumor / adjuvant therapy / doxorubicin / OK-432 / liver regeneration
Research Abstract

Background : Adjuvant chemotherapy may increase the salvage rate after removal of promary liver cancer, but the role of postoperative adjuvant therapy during liver regeneration remains to be clarified.
Methods : To evaluate the preventive effects of Doxorubicin or OK-432 for early hepatic recurrence, five groups of WKA rats had viable tumor cell injected directly into the portal vein after two-thirds hepatectomy. Group one was used as a control, the remaining groups had Doxorubicin injected directly into the hepatic artery : immediately, at 24 hours, 48hours, and 72 hours post-operatively. Secondly, four groups of WKA rats underwent two-thirds hepatectomy and similar injection of viable tumor cells. Group A underwent no further treatment. Group B had Doxorubicin injected 24 hours post-operatively. Group C had OK-432 administered into the subcutaneously transpositioned spleen three times prior to two-thirds hepatectomy. Group D underwent the administration of OK-432, and the Doxorubicin injection.
Results : When compared with regard to the forms of Doxorubicin administered, there was no statistical difference in survival rates between all groups. There were notable adverse side effects of persistent suppression and delay of liver cell devision after Doxorubicin administration. The mean survival period in Group A, B, C, and D was determined to be 22.6, 20.0, 38.6, and 30.9 days, respectively (p<0.01).
Conclusions : Based on the findings we believe adjuvant chemotherapy during the liver regeneration phase is not recommended. OK-432 plays an important role in the preventive effect of liver recurrence after hepatectomy.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Matsumata T,et al.: "Modified technique of Pringle's maneuver in resection of the liver" Surg Gynecol Obstet. 172. 245-246 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsumata T,et al.: "Possible trasmission of serum hepatitis in liver surgery with the ultrasonic dissector" Surgery. 109. 284-285 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsumata T,et al.: "A simplified hilar division in controlled right hepatectomy" Am J Surg. 163. 339 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsumata T,et al.: "Controlled left lateral segmentectomy of the liver" Hepato-gastroenterol. 39. 177-181 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yanag K,et al.: "Alternate hemihepatic vascular control technique for hepatic resection" Am J Surg. 165. 365-366 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsumata T,et al.: "The association between transfusion and cancer-free suevival after curative resection for hepatocellular carcinoma" Cancer. 72. 1866-1871 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsumata T, et al.: "Modified technique of Pringle's maneuver in resection of the liver" Surg Gynecol Obstet. 172. 245-246 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsumata T, et al.: "Possible transmission of serum hepatitis in liver surgery with the ultrasonic disector" Surgery. 109. 284-285 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsumata T, et al.: "A simplified hilar division in controlled right hepatectomy" Am J Surg. 163. 339 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsumata T, et al.: "Controlled left lateral segmentectomy of the liver" Hepato-gastroenterol. 39. 177-181 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] YANAGA,K, et al.: "Alternate hemihepatic vascular control technique for hepatic resection" Am J Surg. 165. 365-366 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsumata T, et al.: "The association between transfusion and cancer-free suevival after curative resection for hepatocellular carcinoma" Cancer. 72. 1866-1871 (1993)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1995-03-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi