1993 Fiscal Year Final Research Report Summary
Analysis of Ag-Ab reaction in HTLV-I mother to child infection
| Project/Area Number |
03670797
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Wakayama Medical College, Kihoku Branch (1993)
Nara Medical University (1991-1992) |
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Principal Investigator |
ANDO Yoshiya 和歌山県立医科大学, 紀北分院・産婦人科, 教授 (90145855)
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| Project Period (FY) |
1991 – 1993
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| Keywords | HTLV-I / Infection / Synthetic peptide / HTLV-I Antibody |
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| Research Abstract |
I examined the function of the antibody fruction for HTLV-I.Antibody for HTLV-I env gp46^<175-199> and gp46^<242-257>, neutralize the infectivity from HTLV-I bearing cell line cells to normal peripheral blood lymphocytes in vitro, but not effect the HTLV-I antigen expression from HTLV-I carrier's PBL in culture. In contrast, antibody for HTLV-I gag p19^<100-130> diminishes the HTLV-I antigen expression from HTLV-I carrier's PBL, but not recognized the neutralizing function in vitro.
So, protective effect on HTLV-I infection persisted in the antibody for the env and gag, especially antibody for gag, functionated to supression of HTLV-I related protein production.
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