1993 Fiscal Year Final Research Report Summary
X-Ray Analysis of Crystal Structure of Picrates of many kinds of Organic Compounds
| Project/Area Number |
03671010
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | School of Pharmaceutical Sciences, Kitasato University |
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Principal Investigator |
TAKAYANAGI Hiroaki Kitasato Univ.Pharmcetical Dep.Professor, 薬学部, 教授 (00050477)
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| Co-Investigator(Kenkyū-buntansha) |
FURUHATA Kimio Kitasato Univ.Pharm.Dep.Lecturer, 薬学部, 講師 (60050605)
OGURA Haruo Kitasato Univ.Pharm.Dep.Professor, 薬学部, 名誉教授 (90050335)
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| Project Period (FY) |
1991 – 1993
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| Keywords | X-ray analysis / picrates / ctystal structure / benzene picrate / quinoline picrate / isoquinoline picrate / aniline picrate / pi-bonding |
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| Research Abstract |
Picric acid forms stable picrates with various organic molecules through pi-bonding or ionic bonding, and such picrates have been very useful for identification and qualitative analysis. But there have been only a few studies on their crystal structures. As it desirable to determine the crystal structures and the bonding mode of picrates of basic compounds, we have syatematically investigated the crystal structures of basic organic compounds. We have determined crystal structures of picrate of aromatic hydrocarbon (benzene, omicron-, m-, p-phenylendiamine), amino acid(glycin), drug(procaine).
From the above results, picrate of aromatic hydrocarbons are formed through pi-bonding. Picrates of amino compounds are mainly formed through ionic bonding, but some of them are formed by both pi- and ionic bondings.
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