1992 Fiscal Year Final Research Report Summary
Pharmacological Analysis Of Thrombogenesis Factors In Experimental Animals With Some Diseases
| Project/Area Number |
03671097
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
応用薬理学・医療系薬学
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
TAKIGUCHI Yoshiharu Hamamatsu University School of Medicine, Department of Pharmacology, Assistant, 医学部, 助手 (40163349)
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Mitsuyoshi Hamamatsu University School of Medicine, Department of Pharmacology, Professor, 医学部, 教授 (00092982)
UEMATSU Toshihiko Hamamatsu University School of Medicine, Department of Pharmacology, Assistant P, 医学部, 助教授 (50151832)
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| Project Period (FY) |
1991 – 1992
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| Keywords | Thrombogenesis / Thrombosis Model / Platelet Aggregation / Diabetes / Hypertension / Hypercholesterolemia / Rat |
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| Research Abstract |
We examined the effects of diabetes, hypertension and hypercholesterolemia on thrombus formation in rats by using of photochemically induced thrombosis model which we have developed. Short-term diabetic rats showed the delayed thrombus formation, although platelet aggregability was enhanced. Plasma isolated from the diabetic rats inhibited platelet aggregation, which may be responsible for the delayed thrombogenesis. The factor(s) accounting for the antiaggregating effect of diabetic plasma has not yet been characterized. Spontaneously hypertensive rats also showed the delayed thrombus formation. High blood pressure mainly interferes with the establishment of thrombus directly. Hypoaggregability of platelets is likely to be partly involved in the prolongation of thrombogenesis. On the other hand, in hypercholesterolemic rats, increased platelet aggregation and platelet-derived vasoconstriction may contribute to the accelerated thrombogenesis.
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