1993 Fiscal Year Final Research Report Summary
The effect of tumor necrosis factor-alpha on hypothalamopituitary -ovarian axis
| Project/Area Number |
03807107
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka University |
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Principal Investigator |
KOIKE Koji Osaka Univ, Med.School Assistant Professor, 医学部, 助手 (70225340)
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| Co-Investigator(Kenkyū-buntansha) |
HIROTA Kenji Osaka Univ, Med.School Lecturer, 医学部, 講師 (00189888)
IKEGAMI Hiromasa Osaka Univ, Med.School Assistant Professor, 医学部, 助手 (10184409)
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| Project Period (FY) |
1991 – 1993
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| Keywords | tumor necrosis factor-alpha / anterior pituitary / arachidonate / Hypothalamus / Paracrine |
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| Research Abstract |
There is an accumulating evidence of a close linkage between neuroendocrine and immune system. Studies are designed to investigate the effect of tumor necrosis factor-alpha (TNF-alpha) on hypothalamo-pituitary-ovarian axis. First, we demonstrated that TNF-alpha stimulated interleukin-6 (IL-6) production by hypothalamic cells. Further we have shown that IL-6 stimulated GnRH release from hypothalamic cessl(1), suggesting that cytokines such as IL-6 and TNF-alpha are involved in the feedback mechanism of estrus cycle. We also demonstrated that TNF-alpha stimulated IL-6 production by anterior pituitary cells and our results also suggested that folliculo-stellate (FS ) cell is one of the candidates of IL-6-producing cells(2). In addition, we observed that TNF-alpha stimulated the release of arachidonate from anterior pituitary cells and arachidonate metabolites such as 5-lipoxygenase products are involved in the process of prolactin release(3).
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