1993 Fiscal Year Final Research Report Summary
TECHNOLOGY ASSESSMENT OFBLOOD PURIFICATION FOR THE ELDERLY
| Project/Area Number |
04041032
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Field Research |
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| Research Institution | University of East Asia |
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Principal Investigator |
HORIUCHI Takashi Graduate School of University of East Asia, 大学院・応用生命科学専攻, 教授 (10201758)
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| Co-Investigator(Kenkyū-buntansha) |
NOSE Yukihiko Dept. of Surgery, Baylor Medical Collage, 外科, 教授
SARANUMMI Niilo Tampere University of Technology, 教授
WERYNSKI Andrzej Polish Academy of Science, 教授
JAFFRIN Michael Technological University of Compiegne, 教授
MALCHESKY Paul S Dept. of Surgery, Baylor Medical Collage, 外科, 客員教授
OHTA Yuji Fac. of Eng., The University of Tokyo, 工学部・精密機械工学科, 助教授 (50203807)
MURABAYASHI Shun Fac. of Eng., Hokkaido University, 工学部・生体工学専攻, 助教授 (30200306)
DOHI Takeyoshi Fac. of Eng., The University of Tokyo, 工学部・精密機械工学科, 教授 (40130299)
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| Project Period (FY) |
1992 – 1993
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| Keywords | Blood purification / Elderly / CAPD / Apheresis / Cell manipulation / cell stimulation |
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| Research Abstract |
As a final year of the project, we focused on three subjects, namely (1) continuousambulatory peritoneal dialysis, (2) apheresis as a preventive therapy and (3) handling cells and proteins by physical principle. A part of the survey was presented at 5th International Conference of World Apheresis (symposium : New separation and apheresis technologies, Houston, March, 1994)
1. Technology assessment of CAPD for the elderly
As mentioned generally, catheter exit infection, deterioration of the peritoneal membrane, under dialysis and malnutrition are main issues to be overcome for the elderly patients, too. Based on our interviews with Dr.Nissenson (UCLA, USA), Dr.Kharna (Univ. of Miss, USA), Dr.Shreiber (Clev. Clin. Found., USA), substitution of hypersonic agent from glucose to amino acid or polypeptide may improve malnutrition and maintain a function of the peritoneal membrane. To overcome under dialysis status in some patients, programmable machine, which can controlinjection and discard of dialysate automatically, could be effective if mass transport in the peritoneal cavity is well known in each patient. Infection seems to be not technologicalissue but more likely educational one.
2. Blood purification as a preventive modality
Some blood purification procedures have possibility to prevent total loss of the organ function that may be promising to decrease the patient population. Removal of LDL has been proved to decrease risk factors of heart failure. Extracorporeal immuno-modulation may activate patient's own immune response. The key issue in this category is to handle or stimulate immune response cells selectively.
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