1994 Fiscal Year Final Research Report Summary
Japan-China Study on Genetic Factors for CVD Prevention
| Project/Area Number |
04044119
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Institution | Kyoto University (1993-1994)
Shimane Medical University (1992) |
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Principal Investigator |
YAMORI Yukio Graduate School of Human & Environmental Studies, Kyoto University, 大学院・人間・環境学研究科, 教授 (80025600)
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| Co-Investigator(Kenkyū-buntansha) |
李 い和 広東省, 人民医院・広東心血管病研究所, 副主任医師
趙 光腫 上海第二医科大学, 高血圧研究所, 所長
SAWAMURA Makoto Graduate School of Human & Environmental Studies, Kyoto University, 大学院・人間・環境学研究科, 助手 (00187303)
李 泰清 中国国際医学交流センター, 西北分センター国際部, 部長
NARA Yasuo Graduate School of Human & Environmental Studies, Kyoto University, 大学院・人間・環境学研究科, 助教授 (80116417)
ZHOU Guang zhong Shanghai Second Medical University, Hypertensive Institute
LI Tai xing China International Medical Center
LI Yi he Guangdong Cardiovascular Institute, Guangdong Provincial Hospital
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| Project Period (FY) |
1992 – 1994
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| Keywords | Hakka / Hypertension / Genetic factor for hypertension / Nutrition |
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| Research Abstract |
We conducted nutritional and cardiovascular disease (CVD) epidemiological study on genetic factors for CVD prediction and prevention in Meixian, Guangdong, People's Republic of China. Fifty-five males (M) and 65 females (F) at the age of 40-60 were recruited (78% response rate) from Hakka people living around Meixian area for height and body weight measurement, blood pressure (BP) , 24hour urine (24hu) collection, blood test and medical interview on diet and medical history. They showed low body mass index (Kg/m^2) (M : 20.9<plus-minus>3.2, F : 21.5<plus-minus>2.6, mean<plus-minus>SD) and relatively low systolic BP (SBP) (M : 127.7<plus-minus>19.0, F : 122.6<plus-minus>20.4 mmHg) and diastolic BP (DBP) (M : 75.5<plus-minus>12.0, F : 70.3<plus-minus>11.6) having low rate of hypertensive (HT) patient who showed SBP <greater than or equal>160 and/or DBP <greater than or equal>95 and/or on anti-HT medication. 24hu sodium (Na) excretion (M : 158.5<plus-minus>68.3 mEq/day, F : 150.0<plus-minus>63.2) was relatively low level among Chinese populations. Potassium (K) (M : 38.0<plus-minus>20.7 mEq/day, F : 37.5<plus-minus>15.5) was not high enough, so their Na/K ratio (M : 4.7<plus-minus>2.0, F : 4.4<plus-minus>1.9) did not reach ideal level. 24hu taurine (TAU) excretion (M : 1437.7<plus-minus>1160.4 mEq/day, F : 1721.3<plus-minus>1077.1) , which has beneficial effects against HT and atherosclerotic diseases, was relatively high level among Chinese populations, but less than Japanese populations taking a lot of sea-foods. TAU could be derived from liver and kidney of animals (pig, cow, etc.) , as well as sea-food protein, people in Meixian often intake pig's internal organs. We picked up 10 families from Hakka people for HT genes analysis, 3 of them had serious HT
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