| Co-Investigator(Kenkyū-buntansha) |
OKUMURA Yutaka Nagasaki University, School of Medicine, 医学部, 教授 (00073130)
KANO Eiichi Fukui Medical School, 医学部, 教授 (70065910)
NAGASAKA Tetsuo School of Medical, Kanazawa University, 医学部, 教授 (80023646)
IRIKI Masami Yamanashi Medicine University, 医学部, 教授 (90072967)
KUROSHIMA Akihiro Asahikawa Medical College, 医学部, 教授 (90002774)
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| Research Abstract |
The present Research project on the varient modification of thermosensitivity in the cellular and bodily level is characterized by the interdisciplinary research fields that are composed of 8 Environmental physiologists, 3 Radiation Biologist, 2 Molecular Biologists and 3 Neuro-physiologists.
1.The essential problems concerned with themosenstivity as well as with thermo-tolerance of cellular function were analyized from the view points of themoregulatory, febrile, sweating, immunological, endocrinological, cellular, and molecular biological levels.
2.The thermoregulatory set-point and its modication of the varient neuro-peptides such like neurotensin, bombesin, neuropeptide Y.calcitonin gene-related peptide (CGRP) were reported by the present Environmental physiologists.
3.Thermosensitivity and thermotolerance are modified not only by the above-mentioned neuropeptides but also the variant cytokines such like IL-1alpha beta, Heat Shock Proteins (HSP70,47), Quercetin(Suppressor of HSP induction) and LPS-pyrogen which were reported by radiation and molecular Biologists.
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