| Co-Investigator(Kenkyū-buntansha) |
SHIONOYA Mitsuhiko Hiroshima Univ., School of Medicine, Associate Prof., 医学部, 助教授 (60187333)
KOIKE Tohru Hiroshima Univ., School of Medicine, Associate Prof., 医学部, 助教授 (90186586)
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| Research Abstract |
1. Novel macrocyclic polyamine-Zn^<II> complexes were synthesized, which selectively recognize thymine (or uracil) among all the nucleobases. The recognition mechanism was elucidated, which was successfully applied to a biochemical control of "protein synthesis".
2. New macrocyclic polyamines possessing a dimer structure showed potent antiAIDS activities.
3. New macrocyclic polyamine-gold complexes were synthesized, which have a high potential as novel, pollution-free gold-plating agents.
4. A number of macrocyclic polyamine complexes having an electron-pool function were synthesized, which catalyze CO_2 reduction.
5. New macrocyclic polyamines appended with an alcoholic group were synthesized, which were shown to be the first alkaline phosphatase model.
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