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1993 Fiscal Year Final Research Report Summary

The role of human parvovirus infection in rheumatoid arthritis

Research Project

Project/Area Number 04454232
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 内科学一般
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

SASAKI Takeshi  DEPARTMENT OF CLINICAL AND LABORATORY MEDICINE, TOHOKU UNIV.SCH.MED.PROFESSOR, 医学部, 教授 (50110656)

Co-Investigator(Kenkyū-buntansha) ENDO Kazuyasu  DEP.INT.MED.TOHOKU UNIV.SCH.MED.INSTRUCTOR, 医学部, 講師 (60125507)
SUGAMURA Kazuo  DEP.BACTERIO.TOHOKU.UNIV.PROFESSOR, 医学部, 教授 (20117360)
Project Period (FY) 1992 – 1993
Keywordshuman parvovirus / rheumatoid arthritis / persistent infection
Research Abstract

1.An enzyme-linked immunoassay (ELISA) for the detetion of human parvovirus B19 was established by obtaining recombinant VP-1 antigen of B19.2.We have demonstrated the relationship between human parvovirus B19 infection and rheumatiod arthritis. Some patients became positive for rheumatiod factors after acute B19 infection and developed chronic polyarthritis with the destruction of the joints which was compatible with rheumatoid arthritis. We could detect B19 DNA in their bone marrow samples three years after the infection. T cell showed an cnhanced response to VP-1 antigen of B19 in vitro. The search by PCR revealed the incidence of B19 DNA in RA as well as in acute parvovirus infection. The target organs for the persistent infection of B19 included bone marrow and synovial tissues. We further tried to characteriza DNA seqauences of B19 obtained from bone marrow in RA.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] T.Ohteki,T.Sasaki: "Age-associated increase of CD5+ B cells in the liver of auto-immune NZB/WZ1 mice." Microbiol.Immunol.37. 221-228 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Hirabayashi,T.Sasaki: "Human B cell clones expressing lupus nephritis-associated anti-DNA idiotypes are prefentially expanded without automatic mutation" Scand.J.Immunol.37. 533-540 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Ishii,T.Sasaki: "Systemic amyloidosis in a patient with adult onset Still's disease." Jap.J.Int.Med.32. 50-52 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Fillit,T.Sasaki: "Autoantibodies to the protein core of vascular basement membrane heparan sulfate proteoglycan in systemic lupus erythematosus." Autoimmunity. 3. 243-249 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S,Shibata,T.Sasaki: "Autoantibodies to heparan sulfate in systemic lupus erythmatosus react with endothelial cells and inhibit the formation of thrombin-antithrombin III complexes" Clin.Immunol.Immunopath.(in press). (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Yaegashi,K.Sugamura.: "The frequency of human parvovious B19 infection in nonimmune hydrops fetalis." J.Perinatal.Med.(in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より

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Published: 1995-03-27  

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