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1993 Fiscal Year Final Research Report Summary

Rapid Diagnosis of Infectious Diseases Using PCR

Research Project

Project/Area Number 04454275
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionHokkaido University

Principal Investigator

TOGASHI Takehiro  Hokkaido University, School of Medicine, Ass.Prof., 医学部, 助教授 (70001930)

Project Period (FY) 1992 – 1993
KeywordsPCR / rapid diagosis / Mycobacterium truberculosis / Mycoplasma pneumoniae / Measles virus / HTLV-1
Research Abstract

In this study polymerase chain reaction was used as a rapid and sensitive method for detecting infectious agents for which four assay systems were devised comprising the methods for the amplification of human T cell leukemia virus type I, Mycobacterium tuberculosis, Mycoplasma Pneumoniae and measles virus. In the study on human T cell leukemia virus type I, the possibility of vertical transmission of this virus through cord blood was demonstrated in the experiment using cord blood mononuclear cells from carrier mothers of this virus. In the study on Mycobacterium tuberculosis, this method was shown to be efficient, particularly in detecting this organism in extrapulmonary cases. In the study on Mycoplasema pneumoniae, evidence of direct invasion into the central nervous system by this orgenism and the concomitant occurrence of mycoplasmaemia in the mycoplasmal central nervous system involvement was obtained. Measles virus RNA was detected in 3 of 4 patients with measles encephalitis in the cerbrospinal fluid samples obtained within a day of the onset of neurological symptoms suggesting that the virus is cleared from the central nervous system very early in the usual course of an acute measles encephalitis.
These results validated the potential of polymerase chain reaction in clinical research of infectious diseases.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Yoshihiro Matsuzono: "Detection of measles virus from clinical samples using polymerase chain reaction." Arch Pediatr Adolesc Med(Am J Dis Child). (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shinji Saitoh: "Mycoplasma pneumoniae infection may cause striatal lesions leading to acute neurological dysfunction." Neurology. 43. 2150-2151 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 富樫武弘: "麻疹ウイルス感染症" 日小児会誌. 97. 1543-1546 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mitsuo Narita: "Polymerase chain reaction for detection of Mycobacterium tuberculosis." Acta Paediatr. 81. 141-144 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mitsuo Narita: "Nested amplification protocol for the detection of Mycobacterium tuberculosis." Acta Paediatr. 81. 997-1001 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mitsuo Narita: "DNA diagnosis of central nervous system infection by Mycoplasma pneumoniae." Pediatrics. 90. 250-253 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshihiro Matsuzono: "Detection of measles virus from clonical samples using polymerase chain reaction." Arch Pediatr Adolesc Mcd (Am J Dis Child). in press.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shinji Saitoh: "Mycoplasma pneumoniae infection may cause striatal lexions leading to acute neurological dysfunction." Neurology. 43. 2150-2151 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takehiro Togashi: "Measles virus infection." J Japan Pediatr Soc(Jpn). 97. 1543-1546 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitsuo Narita: "Polumerase chain reaction for detection of Mycobacterium tuberculosis." Acta Paediair. 81. 141-144 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitsuo Narita: "Nested amplification protocol for the detection of Mycobacterium tuberculosis." Acta Paediatr. 81. 997-1001 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitsuo Narita: "DNA diagnosis of central newvous system infection by Mycoplasma pneumoniae." Prdiatrics. 90. 250-253 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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