1994 Fiscal Year Final Research Report Summary
Development of a Silastic Hollow Fiber Oxygenator Driven with a Hyperbaric Oxygen Pressure Controller with an Ultrasonic Bubble Detector
| Project/Area Number |
04454341
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | National Cardiovascular Center Research Institute (1993-1994)
Tokyo Medical and Dental University (1992) |
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Principal Investigator |
TSUJI Takayuki National Cardiovascular Center Research Institute Department of Surgical Research Director, 実験治療開発部, 部長 (00075764)
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| Co-Investigator(Kenkyū-buntansha) |
MASUZAWA Tooru National Cardiovascular Center Research Institute Department of Artificial Organ, 人工臓器, 室員 (40199691)
MIYAWAKI Fujio National Cardiovascular Center Research Institute Department of Surgical Researc, 実験治療開発部, 室長 (50174222)
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| Project Period (FY) |
1992 – 1994
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| Keywords | hyperbaric oxygenator / blind-ended silastic hollow fiber / ultrasonic bubble detector / intracaval oxygenator / gas pressure regulator / 高圧酸素 |
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| Research Abstract |
Development of an intracorporeal silastic hollow fiber membrane oxygenator capable of indwelling in caval vein was attempted for exclusive use of oxygenation for long term respiratory assist.
A blind-ended silastic hollow fiber oxygenator was infused extracapillarily with hyperbaric oxygen controlled by a gas pressure regulator driven with voltage output fed back with signal from an ultrasonic bubble detector placed on the downstream blood tubing in order to prevent oxygen bubbling which appears in oversaturated state due to hyperbaric oxygenation. The system could keep maximal oxygenation without bubble appearance by feed-back circuit in a mock circulation.
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