1993 Fiscal Year Final Research Report Summary
Basic an clinical studies for the utilization of intraoperative monitoring of the spinal cord motor tractus
| Project/Area Number |
04454386
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
麻酔学
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| Research Institution | YAMANASHI MEDICAL UNIVERSITY (1992, 1994)
Wakayama Medical College (1993) |
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Principal Investigator |
TAMAKI Tetsuya Dept. of Orthopedic Surgery, Wakayama Medical College, Professor, 整形外科, 教授 (30009592)
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| Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Hirofumi Dept. of Orthopedic Surgery, Wakayama Medical College, assistant, 整形外科, 助手 (50214846)
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| Project Period (FY) |
1992 – 1994
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| Keywords | Spinal cord monitoring / transcranial electrical stimulation / transcranial magnetic stimulation / motor evoked potential |
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| Research Abstract |
Currentry 2 kinds of method are used to monitor intraoperative spinal cord motor function. One of them is to record descending volleys from the spinal cord after stimulating the motor cortex of the brain. The other is to use myogenic action potential generated by the stimulation to the spinal cord.
Animal experital studies were carried out to understand responsible tractus in the spinal cord delivering motor evoked potential after the brain stimulation(MEP) and appropriate atimulating condition to provocate myogenic action potential in peripheral muscles. Japanese monkeys and cats were used for experimental atudies. MEP recorded from the spinal cord after stimulating the brain with electrical current and magnetic atimulation conducted through mainly pyramidal tructus, aithough, the extra pyramidal tructus and some antidromically conducted potentials via large diameter sensory tructus were also involved in the MEP.MEP recorded in human candidates after electric stimulation and magnetic atimulation to the brain were regarded to be feasible for the spinal cord function intra-operatively.
Evoked EGM after stimulation to the spinal cord was evoked by 5 to 10 train stimulations, ehich stimulation interval was I msec, under inhalation anesthesia.
Clinical utilization of the evoked EGM was carried on patients who had normal or slightly impaired spinsl cord function. Fairly stable EGM activities were obtained from the majority of the cases which warrant further clinical studies.
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