1994 Fiscal Year Final Research Report Summary
Dizziness and sensorineural hearing loss due to endolymphatic hydropse and its treatment
| Project/Area Number |
04454433
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | OSAKA CITY UNIVERSITY |
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Principal Investigator |
NAKAI Yoshiaki Osaka City University Medical School, Professor, 医学部, 教授 (10046998)
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| Co-Investigator(Kenkyū-buntansha) |
SAKASHITA Tetsushi Osaka City University Medical School, Assis.professor, 医学部, 助手 (20205743)
MASUTANI Haruhiko Osaka City University Medical School, Assis.professor, 医学部, 講師 (10190357)
KONISHI Kazuo Osaka City University Medical School, Assis.professor, 医学部, 講師 (50145801)
OHASHI Yoshihiro Osaka City University Medical School, Assoc.professor, 医学部, 助教授 (60160602)
YAMANE Hideo Osaka City University Medical School, Assoc.professor, 医学部, 助教授 (60145787)
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| Project Period (FY) |
1992 – 1994
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| Keywords | Inner ear / Endolympatic hydropse / Meniere's disease / Cochlear blood flow / Non-specific defense / Acoustic trauma / Free radical / otoacoustic emission |
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| Research Abstract |
The humoral factors in the inner ear fluid was not so powerful in suppresing viral infection and the endolympohatic sac didnot seem to play an important role in the defense against this pathiogen to rescue the cochlea. The inner ear seems to be an environment which is relatively difficult for immunocompetent cells such as NK cell to perform their functions. The effect of acoustic trauma on cochlear strial circulation was investigated imuunohistologically in the guinea pig. Kanamycin was used as a tracer of blood flow. Besides, histochemical examination were made to ascertain the emergence of free radicals in the cochlea after acoustic trauma. The blood flow in the stria vascularis was greatly diminished. The cause of acoustic trauma is obscure. But superoxide anion radicals (O^-_) may be related to strial blood cieculation and affect strial function.
In the avian inner ear, hair cells can regenerate with mitotic cell proliferation. In this study, we examined apoptosis in the process of hair cell regeneration after acoustic trauma. And the results indicate that apoptosis might take part in the process of hair cell regeneration in the avian inner ear after acoustic trauma.
Click-evoked otoacoustic emission (EOAE) was adapted on the patients with Meniere's ear for daignosing from other sensorineural hearing loss. As the results, EOAE is a useful examination for detecting endolympahtic hydropse.
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[Publications] M.Yamane,Y.Nakai,T.Nakagawa,K.Konishi,H.Iguchi,K.Morinaka,M.Takayama,H.Cho,K.Takahashi: "Metalolic activity and regeneration of auian teir cells" Ed(T.Takahashi)Proc,sendai Symposium 92, 57-61 (1992)
Description
「研究成果報告書概要(和文)」より
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