1993 Fiscal Year Final Research Report Summary
Purification of inhibitor of DNA synthsis in hepatoyte from blood of FHF patients
| Project/Area Number |
04670412
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | UNIVERSITY OF TOKYO |
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Principal Investigator |
YAMADA Haruki TOKYO UNIVERSITY DEPARTMETN FACULTY OF MEDICINE ASSISTAN, 医学部(病), 助手 (70174729)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Naoaki TOKYO UNIVERSITY DEPARTMETN FACALTY OF MEDICINE ASSISTAN, 医学部附属病院, 助手 (00167579)
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| Project Period (FY) |
1992 – 1993
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| Keywords | DNA synthosis / Livr Regeneration |
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| Research Abstract |
Inhitiory activity for DNA synthosis in adultrat primany hepatocyte culture, was measured in plasma from 20patient with actute liver failure. Inhibitory activity was increased in plasma of the patients with poor prognosis. Inhibitory activity was still inoreased after hepatic coma was disppeared by artifitial liver support.
Inhibitory activity in plasma from two individual FHF pationts was separated using heparing columm and HPLC (Amid80). Molecular size of the inhibitory activity was newgnized in the fraction between 100 and 3000 delton by membrane filtuation
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