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1993 Fiscal Year Final Research Report Summary

STUDIES ON THE DEVELOPMENT OF CIRCADIAN, ULTARADINAN AND INFRADIAN RHYTHMS IN BIOLOGICAL ACTIVITY.

Research Project

Project/Area Number 04670572
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionASAHIKAWA MEDICAL COLLEGE

Principal Investigator

OKUNO Akimasa  ASAHIKAWA MEDICAL COLLEGE DEPT PED, PROFESSOR, 医学部, 教授 (10000960)

Co-Investigator(Kenkyū-buntansha) KAKUYA Fujio  ASAHIKAWA MEDICAL COLLEGE DEPT PED, INSTRUCTOR, 医学部, 助手 (70240645)
ITO Yoshiya  ASAHIKAWA MEDICAL COLLEGE DEPT PED, INSTRUCTOR, 医学部, 助手 (70241437)
OKI Junichi  ASAHIKAWA MEDICAL COLLEGE DEPT PED, INSTRUCTOR, 医学部, 助手 (60152401)
AZUMA Hiroshi  ASAHIKAWA MEDICAL COLLEGE DEPT PED, INSTRUCTOR, 医学部, 助手 (00167909)
Project Period (FY) 1992 – 1993
KeywordsCIRCADIAN RHYTHM / ULTRADIAN RHYTHM / INFRADIAN RHYTHM / LETEINIZING HORMONE / FOLLICLE STIMULATING HORMONE / TESTOSTERONE / PUBERTY / 性成熟
Research Abstract

Biological rhythms were studied on the development of pituitary-gonadal function in children and adolescents, the weight gain in low-birth weight infants and the cardiac functions in the children with insulin dependent diabetes mellitus.
(1) Characteristics of physical growth and hormonal changes during childhood and adolescence studied on the basis of height velocity, testicular size, and 24-hr secretory pattern of LH, FSH and testosterone. Definite pulsatile secretion and day-night rhythm are observed in the hormonal concentrations as early as five years of age. The mean 24-hr concentrations of LH and FSH started to increase one year before the testicular size came to 3 ml. Immediately after the rise in LH and FSH, the minimal prespurt height velocity was attained and the the mean 24-hr testosterone concentration started to increase.
(2) Body-weight measured every other day was analyzed for rhythms of weight velocity in low birth eight infants. There was an infradian rhythm with a cycle of 9.28 (〕SY.+-.〔) l.05 days. This infradian rhythm in the weight velocity was not affected by water and energy intake and medical manipulation.
(3) Cardiac contraction rhythms were analyzed by doppler echocardiography in the patients with insulin-dependent diabetes mellitus. Measurement of the mitral and tricuspidal flow showed prolongation of the early diastolic phase of the both ventricle.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 角谷不二雄: "体重増加の長日リズム:低出生体重児における検討" 日本小児科学会雑誌. 96. 2048-2053 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshiya Ito: "Sporadic Testotoxicosis in Japanese Children." Clin Pediatr Endocrinol. 1. 95-100 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 三田村亮: "思春期の発来と血清テストステロン・黄体化ホルモンの日内リズムとの関係" 日本小児科学会雑誌. 97. 2101-2110 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 土田晃: "インスリン依存性糖尿病患児における心機能の検討" 日本小児科学会雑誌. 97. 2412-2420 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akimasa Okuno: "Physical Growth and Hormonal Chnages in Late Childhood" Clin Pediatr Endocrinol. Suppl 3. 1-6 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kakuya F, Tsuda N, Hayashi T, shirai M, Ishioka t, Okuno A: "An infradian rhythm of weight velocity on low birth weight infants." J Japn Pediatr Soc. 96( Janpanese ). 2048-53 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kakuya F, Tsuda N, Hayashi T, shirai M, Ishioka t, Okuno A: "An infradian rhythm of weight velocity on low birth weight infants." J Japn Pediatr Soc. 96( Janpanese ). 2048-53 (1992)Ito Y, Yano K, Mitamura R, Oka R, Okuno A, Kataoka N, Hiraba K, Moriya N : Sporadic testotoxicosis in Janpanese children : report of 4 cases. clin Pediatr Endocrinol 1 : 95-100, 1992:

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitamura R, Ohmi H, Ito Y, Suzuki N,Yano K, Okuno A: "Diurnal rhythms of testosterone and luteinizing hormone in boys before and during the onset of puberty." J Japn Pediatr Soc. 97( Japanese ). 2101-10 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuchida A, Mitamura R, Sakaino T, Saito T, Ito Y, Suzuki N, Yano K, Oka R, Okuno A: "doppler echocardiographic evaluation of left and rightventricular functions in young subjects with insulin-dependent diabetes mellitus." J Japan Pediatr Soc. 97( Janpanese ). 2412-20 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okuno A: "Physical growth and hormonal changes in late cildhoodand early adolescence." clin Pediatr Endocrinol. Suppl 3. 1-6 (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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