1993 Fiscal Year Final Research Report Summary
BETA-OXIDATION OF FATTY ACIDS DURING RECOVERY FROM COLD ISCHEMIA OF THE LIVER IN SITU
| Project/Area Number |
04670729
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | MIE UNIVERSITY |
|---|
Principal Investigator |
KITAGAWA Tatsushi MIE UNIVERSITY.UNIVERSITY HOSPITAL.ASSISTANT, 医学部・附属病院, 助手 (20169858)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
AZUMA Takaaki MIE UNIVERSITY.FACULTY OF MEDICINE.ASSISTANT, 医学部・附属病院, 助手 (50242938)
|
|---|
| Project Period (FY) |
1992 – 1993
|
| Keywords | Hepatic Ischemia / Parenteral Nutrition / Lipid Emulsion / Fatty Acid / Beta-Oxidation |
|---|
| Research Abstract |
Changes of hepatic energy balance caused by ischemia was determined by measuring beta-ATP/Pi (inorganic phosphrus) using magnetic resonance spectroscopy. Ischemia induced a significant reduction of beta-ATP/Pi. The reduced ratio of beta-ATP/Pi returned to the 85% of the basal value 5 hours after restoration of the hepatic blood-flow. Hepatic ischemia induced also the arterial ketone body ratio (acetoacetate/beta-hydroxybutylate) which is representative of hepatic redox state. Influences of infusions of glucose and/or lipid emulsion on hepatic energy balance after ischmemia were investigated. The results suggested that, after cold ischemia, an immediate supply of a large (0.75g/h/rat) amount of glucose inhibited the recovery of energy balance of the liver, while a supply of limited amounts of glucose (0.37g/h/rat) after some delay did not appear to be detrimental to the liver. Concerning fatty acids oxidation, it was demonstrated that the ischemic liver restores the functions for beta-oxidation after the induction of hepatic blood-flow. The timing of this restoration of function is identical to the timing of the return of the arterial ketone body ratio to the normal range (higher than 0.65). In conclusion, after liver surgery complicated with hepatic ischemia, parenteral use of limited amounts of glucose as well as lipid emulsion appear to enhance recovery of hepatic energy balance a far as these nutritional substates are administered are administered when the arterial ketone body ratio returns to the levil of higher than 0.65.
|
Research Products
(12 results)
