1993 Fiscal Year Final Research Report Summary
RECURRENCE AND PREVENTION OF PANCREATIC GRAFT ON INSULIN DEPENDENT DIABETES MELLITUS
| Project/Area Number |
04670746
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Meikai University, School of Dentistry |
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Principal Investigator |
NOZAWA Masumi Meikai University, School of Dentistry Professor, 歯学部, 教授 (00084880)
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| Co-Investigator(Kenkyū-buntansha) |
MAKINO Susumu SHIONOGI ABURAHI LABOLATRY, 油日ラボラトリーズ, 次長
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| Project Period (FY) |
1992 – 1993
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| Keywords | Anti-adhaesion molecule antibody / Immuene deficiency / 糖尿病自然発症BBラット / RT6^+T細胞 / 抗接着分子抗体 / 免疫不全 |
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| Research Abstract |
Diabetic prone (DP)-BB tats rejected MHC-compatible and mH-incompatible DR pancreases within a MST of 24(〕SY.+-.〔)4.2 days. DR-BB recipients when treated with anti ICAM-1/LFA-A mABs. The recurrence of IDDM was consistently observed in DP-BB recipients transplanted with WFu pancreases. Diabetic DP rats had a feature of lymphocytopenia and T cell hyporesponsiveness against mitogens or alloantigens. In peripheral lymphoid tissues, DP rats also had no RT6^+T cells , which regulate immune responses and correlate with T cell dysfunction an doccurrence of IDDM.This type of T cell dysfunction was mot observed in WFu or DR rats, In the case of IDDM recurrence of WFu to DP combination, the DP recipients still had a feature of T lymphocyopenia and T cell dysfunction without the appearance of RT6^+T cells. The DP recipients, whichrejected DR pancreatic graft, also showed T dell dysfunction with T hymphocytopenia, In this mechanism of rejection, humaral immune responses were enhanced tather than cellular rsponses. As an interesting result of fact, however, DP rats which accepted DR pancreatic grafts with anti-adhesion molecule mAbs demonstrated the increased number of T cells, the restoration of T cell function and the appearanceof RT6^+T cells, which sechanisms are unclear, may be responsible for the restoration of T cell dysfunction and the protection of IDDM recurrence.
Rat pancreas transplantation
IDDM
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[Publications] Ishida H, Seino Y, Takeshita N, Kurose T, Tsuji K, Okamoto Y, Someya Y, Hara K, Akiyam Y, Imura H, Nozawa M.: "Effect of pancreas transplantation on decreased leveds of cieculating bone r-carbosyglutamic acid-containing protein and osteopenia in rats with streptozotocin-induced diabetes." Acta Endocri. 127. 81-5 (1992)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Uchikoshi F, Ito T, Kamiike W, Yamamoto S, Nozaki S, Nakata S, Shirakura R, Miyata M, Matsuda H, Nakao H, Makino S, Nozawa M.: "Resoration of defective immune response in diabetic BB rats after successful pancreas transplantation." Transplant Proc. (in press, 1994).
Description
「研究成果報告書概要(欧文)」より
