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1993 Fiscal Year Final Research Report Summary

Continuous Analysis of metabolism of tissues by in vivo Microdialysis

Research Project

Project/Area Number 04670755
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionTohoku University

Principal Investigator

SHINEHA Ryuzaburo  The second Dept.of Surgery, Research Associate, 医学部, 助手 (20192106)

Co-Investigator(Kenkyū-buntansha) OHKOICHI Nobuhiro  The second Dept.of Surgery, Research Associate, 医学部, 助手 (40213673)
KUROKAWA Yoshimochi  The second Dept.of Surgery, Research Associate, 医学部附属病院, 助手 (80215087)
HIRAYAMA Katsu  The second Dept.of Surgery, Lecturer, 医学部附属病院, 講師 (20181191)
NISHIHIRA Tetsuro  The second Dept.of Surgery, Associate Professor, 医学部, 助教授 (50101142)
Project Period (FY) 1992 – 1993
KeywordsMicrodialysis / chatecholamines / glycerol metabolism / stress
Research Abstract

Microdialysis is a new method which is able to investigate the dynamic changes of metabolizes cotiniously and simultaneously. We investigated the changes of chatecholamines in the hypothalamus and Na-K flux changes in red blood cells, and also, glycerol metabolism in the adipose tissue by stress.
Norepinephrine increased in early phase as the same as peripheral tissue, but fell down in late phase, even though, peripheral Norepinephrine increased. Na-K flux decreased by stress, and also beta-endorphin was secreted.
Adipose tissue glycerol concentration was able to determined by HPLC.Glycerol was excreted by stress from adipose tissue, and tissue glycerol pattern was more clearly and sharply comparing with that of peripheral blood sample.
Microdialysis is a good and fine analytical method for investigating of metabolic changes of surgical stress and nutrition.

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 標葉 隆三郎: "ラット視床下部におけるノルアドレナリンの経時的研究" 外科と代謝・栄養. 3. 200 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 標葉 隆三郎: "in vitro microdialysisを用いた赤血球 Na^+-K flux測定法" 外科と代謝・栄養. 3. 205 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 菅原 浩: "腸問膜脂肪と皮下しぼうのストレス下脂肪分解の比較" 日本静脈・経腸栄養研究会誌. 13. 158-163 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 菅原 浩: "侵襲下における腹腔脂肪組織と皮下脂肪組織の脂肪分解の比較" 外科と代謝・栄養. 32(2). 77-84 (1998)

    • Description
      「研究成果報告書概要(和文)」より

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Published: 1999-03-16  

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