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1994 Fiscal Year Final Research Report Summary

Canine Model of Lung Transplantation from Non-Heart-Beating Donors Following Brain Death

Research Project

Project/Area Number 04670816
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

KONDO Takashi  Tohoku University Institute of Development, Department of Thoracic Surgery, Aging and Cancer : ASSOCIATE PROFESSOR, 加齢医学研究所・呼吸器再建, 助手 (10195901)

Co-Investigator(Kenkyū-buntansha) SAITO Ryo  Institute of Development, Department of Thoracic Surgery, Aging and Cancer : ASS, 加齢医学研究所・呼吸器再建, 助手 (70225689)
Project Period (FY) 1992 – 1994
KeywordsLung transplantation / Brain death / Cardiac death / Dog / RPAO / Graft function
Research Abstract

The candidate for pulmonary transplantation has been limited because of easy susceptibility of infection and edema of the lung in brain-dead donor. To resolve the donor shortage, two possibilities for expanding the donor source can be presented, i.e.xenotransplantation and the transplantation from cardiac-dead donor. The present study was conducted to evaluate the possibility of lung trnsplantation from non-heart-beating donor following brain death using canine model.
Six mongrel dogs were put to brain death by elevating intracranial pressure using the balloon catheter. Following the intravenous administration of methylprednisolone and heparine after the management of brain death for 6 hours, the mechanical ventilation was discontinud leading to cardiac arrest in a few minutes. The excision of the left lung was scheduled twenty minutes after cardiac arrest, following by washing out pulmonary vasculature with cold Ep4 solution, and transplanted orthotopically to the recipient animal.
Immunosuppresion was achieved with Methylprednisolone and azathioprine. Right pulmonary arterial occulusion test (RPAO) was performed to assess the graft function immediately and 7 days after the grafting. All but one animal and three animals with uneventful postoperative course proved to survive with the transplants alone under RPAO immediately and 7 days after surgery, respectively.
These results indicated the possibility of lung transplantation from non-heart-beating donor following brain death.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Kondo T.: "Experimental study of lung trosplantation from non-heart-beating donor following brain death in canine suodel of left lung a llotaucplantation." Acta Bio-Medica de《L'Atenco Parmense》. 65. 133-145 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chura H.: "Primate wcdel of 24-hourpulmonarg preservation for clinical application." Transpl Proc. 26. 885-886 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimada K.: "The passibity of lung trmsplantation from non-neart-beating donors:csperimeal study in canine model." Transpl.Proc. 26. 880-881 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 近藤 丘: "臓器移植と免疫抑制" 臨床と薬物治療. 13. 333-336 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐々木 寛: "自家肺移植における肺内迷走神経再生および副交感神経節機能に関する実験的研究" 加齢医学研究所雑誌. 45. 150-161 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岡田 克典: "臓器保存法" 臨床麻酔. 18. 201-206 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ryo Sito: "Heart,Lung and Heart-Lung Transplantation in the Dog and Pig." CRC press,Boca Raton,Florida,USA., 352 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Kondo.: "Experimental Study of Lung Transplantation from Non-Heart-Beating Donor Following Brain Death in Canine Model of Left Lung Allotransplantation." Acta Bio-Medica de "L'Ateneo Parmense". 65. 133-145 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Ohura, T.Kondo, M.Handa, Y.Okada, K.Shimada, M.Hirose, A Horikoshi, and S.Fujimura.: "Primate Model of 24-hour Pulmonary Preservation for Clinical Application." Transplant.Proc.26. 885-886 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Shimada, T.Kondo, M.Handa, Y.Okada, H.Ohura, M.Hirose, A Horikoshi, T.Sado, M.Sugita, and S.Fujimura.: "The possibility of Lung Transplantation From Non-Heart-Beating Donors : Experimental Study in a Canine Model." Transplant.Proc.26. 880-881 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Kondo.: "Organ Transplantation and Immunossuppression" Clinic and Drug therapy. 13. 333-336 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Sasaki.: "Functional and histological study on parasympathetic nervous system in autotransplanted lung." Kareiigaku kenkyusyo Zasshi. 45. 149-161 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Okada.: "Methods of organ preservation" Clinical Anesthesiology. 18. 201-206 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] R.Saito.: Heart, Lung and Heart-Lung Transplantation in the Dog and Pig.CRC press, Boca Raton, Florida, USA., (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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