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1993 Fiscal Year Final Research Report Summary

Analysis of placental endocrine and immunological function regulated by placenta-derived cytokines

Research Project

Project/Area Number 04671003
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionOsaka University

Principal Investigator

MITSUDA Nobuaki  Osaka Univ. Med. School Dept. of Obstet. and Gyne. Instructor, 医学部, 助手 (50209805)

Co-Investigator(Kenkyū-buntansha) SHIMOYA Kouichiro  Osaka Univ. Med. School Dept. of Obstet. and Gyne. Research Fellow, 医学部・附属病院, 医員 (40291950)
TAKEMURA Masahiko  Osaka Univ. Med. School Dept. of Obstet. and Gyne. Research Fellow, 医学部・附属病院, 医員
KAMIURA Syoji  Osaka Univ. Med. School Dept. of Obstet. and Gyne. Instructor, 医学部, 助手 (10243213)
OHASHI Kazutomo  Osaka Univ. Med. School Dept. of Obstet. and Gyne. Instructor, 医学部, 助手 (30203897)
SAJI Fumitaka  Osaka Univ. Med. School Dept. of Obstet. and Gyne. Assistant Professor, 医学部, 講師 (90093418)
Project Period (FY) 1992 – 1993
KeywordsCytokine / placenta / Trophoblast / Endocrine function / Perinatal infection / Fetomaternal defense mechanism / Chorioamnionitis / RDS
Research Abstract

This grand helped us to investigate placental endocrine activity and placental defense mechanism medeated by trophoblast-derived cytokines. Trophoblast-derived IL-1 and TNF-alpha stimulate IL-6 release and the released IL-6 sebsequently stimulates human choronic gonadotropin (hGC) and human placental lactogen (hPL) through IL-6 receptor (-R). Soluble IL-6-R contribute in postentiation of IL-6-mediated placental endocrine functions. These IL-6-mediated functions were blocked by tyrosine kinase inhibitor, genistein. In contrast, trophoblast-derived TGF-beta (transforming growth factor-beta) suppresses such cytokine-mediated placental endocrime function. Thus, trophoblast-derived cytokines regulate the placental endocrine functions. Thus, trophoblast derived cytokines regulate the placental endocrine functions independently of other stimulants such as gonadotropin releasing hormone (GmRH) and epidermal growth factor (EGF). A cytokine exerts the potentiation of host defense mechanism. To investigate such cytokine-mediated activity in the intrauterine space, we cultured placental tissue with / without chorioamnionitis. Placneta with Chorionaminionits produced a large amount of IL-1alpha, IL-1beta, IL-6, IL-8 and MCAF.These cytokines exert their unipue activities to potentiate fetoplacental defense mechanism and immune responses against infectious stimuli. Fetuses with chorioamnionitis actively produced IL-6 and IL-8. Fetuses with high IL-6 titer showed low incedence of respiratory distress sydrome (RDS) compared with fetuses with low IL-6titer. In contrast, fetuses with high IL-8 itter showed a high degree of chorionaminionitis in comparison with fetuses with low IL-8 titer. Collectively we performed a successful analysis in demonstrration of unique activities placental cytokines in placental functions.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Takeshi Taniguchi et al: "IL-1-induced IL-6-receptor-mediated release of human chorionic gonadotropin by choriocarcinoma cell lines (Jar and HCCM-5) activates adenosine 3'-5'-monophosphate independent signal transduction pathway" J.Clin.endocrinol.& Metabol.74. 1389-1395 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noboru Matsuzaki et al: "Trophoblast-derived transforming growth factor-β,suppresses cytokine-induced,but not gonadotropin releasing hormone-induced,release of human chorionic gonadotropin by normal human trophoblasts" Journal of Clinical Endocrinology & Metabolism. 74. 211-216 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takeshi Taniguchi et al: "Fetal mononuclear cells show a comparable capacity with maternal mononuclear cells to produce IL-8 in response to lipopolysacchainde in chorioamnionitis" Journal of Reproductive Immunology. 23. 1-12 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kouichiro Shimoya et al: "Detection of IL-8 in seminal plasma and elevated IL-8 in seminal plasma of intertile patients with leukospermia" Fertility and Sterility. 59. 885-888 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noboru Matsuzaki et al: "The placental interleukin-6 production is enhanced in intrauterine infection but no in labor." Am.J.of Obstet.& Gyne.168. 94-97 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Reiko Neki et al: "The IL-1/IL-6-receptor system induces human choronic gonadotropin production by activating tyrosine-kinase-dependent signal transduction pathways triggered by protein kinase activators including gonadotropin releasing hormone." J.Clin.endocrinol.& Metabol.77. 704-709 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松崎 昇 他: "臨床免疫" 科学評論社, 8 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松崎 昇 他: "臨床免疫" 科学評論社, 10 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takeshi Taniguchi, et al: "IL-1-induced IL-6-receptor-mediated release of human chorionic gonadotropin by choriocarcinoma cell lines (Jar and HCCM-5) activates adenosine 3'-5'-monophosphate independent signal transduction pathway" J.Clin. Endocrinol. & Metabol. 74. 1389-1395 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noboru Matsuzaki, et al: "Trophoblast-derived transforming growth factor, suppresses cytokine-induced, but not gonadotropin releasing hormone-induced, release of human chrionic gonadotropin by normal human trophoblasts" J.Clin. Endocrinol. & Metabol. 74. 211-216 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takeshi Taniguchi, et al: "Fetal mononuclear cells how a comparable capacity with maternal mononuclear cells to produce IL-8 in receptor lipopolysacchainde in chorionamnionitis" J.Reprod. Immunol. 23. 1-12 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kouichiro Shimaya, et al: "Detection of IL-8 in seminal plasma and elevated IL-8 in seminal plasma intertile patients with leukospermia" Fertil & Steril. 59. 885-888 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noboru Matsuzaki, et al: "The placental interleukin-6 production is enhanced in intrauterine infection but no in labor" Am. J.Obstet & Gynecol. 168. 94-97 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Reiko Neki, et al: "The IL-1/IL-6-receptor system induced human chorionic gonadotropin production by activating tryosine-kinase-dependent signal transduction pathways trigged by protein kinase activators including gonadotropin releasing houmone" J.Clin. Endocrinol. & Metabol. 77. 704-709 (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27   Modified: 2017-03-24  

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