1994 Fiscal Year Annual Research Report

免疫制御・寛容の分子機構

Research Project

Project/Area Number	05272103
Research Institution	Kyushu University
Principal Investigator	笹月健彦九州大学, 生体防御医学研究所, 教授 (50014121)
Co-Investigator(Kenkyū-buntansha)	谷口維紹東大, 医学部, 教授 (50133616) 渡辺武九州大学, 生体防御医学研究所, 教授 (40028684) 岸本忠三阪大, 医学部, 教授 (10093402) 本庶佑京大, 医学部, 教授 (80090504) 奥村康順天堂大, 医学部, 教授 (50009700)
Keywords	免疫制御 / 免疫寛容
Research Abstract	本重点領域研究は、免疫応答の制御機構と免疫寛容の分子機構を解明することにより、現代医学が解決を迫られている臓器・骨髄移植における拒絶反応やGvH病、自己免疫性難病やアレルギー性疾患、さらにはウィルス・細菌感染後の免疫学的炎症などの疾患の根元的制御法、治療法、さらには予防法確立への道を拓くことを目的としている。総括班は、1)免疫制御の分子機構、2)免疫制御の分子機構、3)免疫機構の分子機構の3つの計画班それぞれの研究評価を行い、3班が密な連携をもって研究を推進できるよう以下の活動を行った。 1)年3回のニューズレターの発行を行った。 2)合同シンポジウム、合同カンファレンスを各一回開催した。 3)総括班会議を2回開催し、計画研究班の研究進捗状況の討議および研究支援に関する討議を行った。

Research Products

(15 results)

All Other

All Publications (15 results)

[Publications] Okabe T.: "cDNA cloning of a NGF1-B/nur77 related transcription factor from an apoptotic T cell line." J.Immunol.(in press).
[Publications] Takeda T.: "EIA respression of IL-6-induced gene activation by blocking the assembly of IL-6 response element binding complexes." J.Immunol.(in press).
[Publications] Hara H.: "Detection of human T lymphotropic Virus Type I(HTLV-1) proviral DNA and analysis of T cell receptor V CDR3 sequences in spinal cord lesions of HTLV-1 associated myelopathy Tropical spastic paraparesis." J.Exp.Med.(in press).
[Publications] Rae SM.Yeung: "Human CD4-major histocompatibility complex class II (DOW6) transgenic mice in an endogenous CD4/CD8-deficient background:Reconstitution of phenotype and human restrieted function." J.Exp.Med.180. 1911-1920 (1994)
[Publications] Yamamoto K.: "Functional interaction between human histocompatibility leukocyte antigen(HLA) class II and mouse CD4 molecule in antigen recognition by T cells in HLA-DR and DO transgenic mice." J.Exp.Med.180. 165-171 (1994)
[Publications] Hanabuchi S.: "Fas and its ligand in a general mechanism of T cell-mediated cytotoxity." Proc.Natl.Acad.Sci.USA. 91. 4930-4934 (1994)
[Publications] Koide Y.: "Molecular analysis of the pathogenesis of autoimmune insulitis in NOD mice." Tohoku J.Exp.Med.173. 157-170 (1994)
[Publications] Nakano T.: "Generation of lymphomatopoietic cells from embryonic stem cells in culture." Science. 265. 1098-1101 (1994)
[Publications] Kishimoto,T.: "Cytokine signal transduction." Cell. 76. 253-262 (1994)
[Publications] Akira S.: "Molecular cloning of APRF,a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp 130-mediated signaling pathway." Cell. 77. 63-71 (1994)
[Publications] Kaisho T.: "EST-1,a surface molecule of bone marrow stromal cell lines that facilitates pre-B cell growth." Proc.Natl.Acad.Sci.USA. 91. 5325-5329 (1994)
[Publications] Sawada M.: "cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells." Biochm.Biophys.Res.Commun.203. 479-484 (1994)
[Publications] Tanaka N.: "Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1." Cell. 77. 829-839 (1994)
[Publications] Kimura T.: "Involvement of the IRF-1 transcription factor in antiviral responses to interferones." Science. 264. 1921-1924 (1994)
[Publications] Isobe M.: "Immunosuppression to cardiac allografts and soluble antigens by anti-VCAM-1 and anti-VLA-4 monoclonal antibodies." J.Immunol.153. 5810-5818 (1994)

1994 Fiscal Year Annual Research Report

免疫制御・寛容の分子機構

Principal Investigator

笹月 健彦 九州大学, 生体防御医学研究所, 教授 (50014121)

Research Products

[Publications] Okabe T.: "cDNA cloning of a NGF1-B/nur77 related transcription factor from an apoptotic T cell line." J.Immunol.(in press).

[Publications] Takeda T.: "EIA respression of IL-6-induced gene activation by blocking the assembly of IL-6 response element binding complexes." J.Immunol.(in press).

[Publications] Hara H.: "Detection of human T lymphotropic Virus Type I(HTLV-1) proviral DNA and analysis of T cell receptor V CDR3 sequences in spinal cord lesions of HTLV-1 associated myelopathy Tropical spastic paraparesis." J.Exp.Med.(in press).

[Publications] Rae SM.Yeung: "Human CD4-major histocompatibility complex class II (DOW6) transgenic mice in an endogenous CD4/CD8-deficient background:Reconstitution of phenotype and human restrieted function." J.Exp.Med.180. 1911-1920 (1994)

[Publications] Yamamoto K.: "Functional interaction between human histocompatibility leukocyte antigen(HLA) class II and mouse CD4 molecule in antigen recognition by T cells in HLA-DR and DO transgenic mice." J.Exp.Med.180. 165-171 (1994)

[Publications] Hanabuchi S.: "Fas and its ligand in a general mechanism of T cell-mediated cytotoxity." Proc.Natl.Acad.Sci.USA. 91. 4930-4934 (1994)

[Publications] Koide Y.: "Molecular analysis of the pathogenesis of autoimmune insulitis in NOD mice." Tohoku J.Exp.Med.173. 157-170 (1994)

[Publications] Nakano T.: "Generation of lymphomatopoietic cells from embryonic stem cells in culture." Science. 265. 1098-1101 (1994)

[Publications] Kishimoto,T.: "Cytokine signal transduction." Cell. 76. 253-262 (1994)

[Publications] Akira S.: "Molecular cloning of APRF,a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp 130-mediated signaling pathway." Cell. 77. 63-71 (1994)

[Publications] Kaisho T.: "EST-1,a surface molecule of bone marrow stromal cell lines that facilitates pre-B cell growth." Proc.Natl.Acad.Sci.USA. 91. 5325-5329 (1994)

[Publications] Sawada M.: "cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells." Biochm.Biophys.Res.Commun.203. 479-484 (1994)

[Publications] Tanaka N.: "Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1." Cell. 77. 829-839 (1994)

[Publications] Kimura T.: "Involvement of the IRF-1 transcription factor in antiviral responses to interferones." Science. 264. 1921-1924 (1994)

[Publications] Isobe M.: "Immunosuppression to cardiac allografts and soluble antigens by anti-VCAM-1 and anti-VLA-4 monoclonal antibodies." J.Immunol.153. 5810-5818 (1994)

笹月健彦九州大学, 生体防御医学研究所, 教授 (50014121)