1993 Fiscal Year Annual Research Report

自律神経機能の左右差発現

Research Project

Project/Area Number	05304025
Research Institution	Aichi Medical University
Principal Investigator	小川徳雄愛知医科大学, 医学部, 教授 (50065520)
Co-Investigator(Kenkyū-buntansha)	間野忠明名古屋大学, 環境医学研究所, 教授 (30023659) 永坂鉄夫金沢大学, 医学部, 教授 (80023646) 佐藤昭夫東京都老人総合研究所, 副所長兼部長 (60072980) 彼末一之大阪大学, 医学部, 助教授 (50127213) 小野武年富山医科薬科大学, 医学部, 教授 (50019577)
Keywords	自律神経 / 左右差 / 発汗 / 組織血流量 / 半球優位 / 脳血管障害 / 交感神経支配 / 視床下部
Research Abstract	1.ヒトで、暑熱時に姿勢変換や体性感覚刺激による鼓膜温の左右差と顔面・体幹・四肢末端部の身体各部の発汗活動や皮膚血流量の変化の左右差との間に僅かに関連することを観察した(小川)。左右手部の異なる温度刺激時に、前腕に非蒸散性、蒸散性熱放散量に有意な左右差を認めた(永坂)。片側交感神経節切除後に両側筋交感神経活動を同時記録し、交叉神経の存在を示唆する結果を得た(間野)。2.麻酔ラットの視床下部視束前野(P0)を正中切断しても一側P0加温により両側性にふるえが抑制され、P0尾側で一側の前額面切断を行うと、その側のP0加温が無効になることを観察し、またP0局所加温、薬物の局所投与の効果より温感受性ニューロンが主要な働きをするとの示唆を得た(彼末)。3.サルの一側性脳虚血により起こる海馬体などの神経細胞壊死の程度に左右差はなく、自律神経機能に著明な変化を生じず、脳波の変化にも左右差を認めなかった(小野)。4.麻酔ラットの一側坐骨神経血流が同側及び対側の自律神経幹、L6・S1の前根、後根の刺激により、血圧依存性及び非依存性のの血流増加を認め、alpha、ムスカリン、CGRP各受容体の関与が示唆された(佐藤)。5.一側脳血管障害患者の起立負荷時、左半球障害群では右半球障害群より血圧低下が著しく、心拍数増加は小さく、総頸動脈血流量には著差がなかった(高橋)。脳卒中麻痺患者の急性・慢性病期や障害部位、臨床症状と四肢局所温、前腕発汗量の左右差との関連を認めた(渡邉)。片側脳幹、胸・頸部及び内頸動脈レベルでの交感神経障害例の顔面発汗を観察し、顔面で同側支配が最も強く、顔面発汗の大部分は外頸動脈に沿う節後線維に支配され、一部は内頸動脈に沿う節後線維が関与すると推論した(斎藤)。6.急性期脳卒中の意識障害80例で、Cheyne-Stokes呼吸発現頻度が右半球障害において大で、意識障害、予後とは明らかな関連はないことを認めた(片山)。

Research Products

(46 results)

All Other

All Publications (46 results)

[Publications] 小川徳雄: "発汗活動の生理的・病的変化と自律神経" 東京女子医大雑誌. 63. 56-61 (1993)
[Publications] 小川徳雄: "脳温の左右差の生理的・病態生理的発現" 日本病態生理誌. 1. 12 (1993)
[Publications] 西田元彦: "脳血管障害と鼓膜温" 日本病態生理誌. 1. 30 (1993)
[Publications] Ogawa,T.: "Bilateral differences in tympanic temperatures induced by vascular compression in the head and neck." Jpn.J.Physiol.Supple.2. 786 (1993)
[Publications] Ogawa,T.: "Thermoregulatory responses of old men to gradual changes in ambient temperature." J.Therm.Biol.18. 345-348 (1993)
[Publications] Ogawa,T.: "Pulsatile sweating and sympathetic sudomotor activity." Jpn.J.Physiop. 43. 275-289 (1993)
[Publications] Ogawa,T.: "Effects of body and head positions on bilateral difference in tympanic temperatures." Eur.J.Appl.Physiol.67. 354-359 (1993)
[Publications] Ogawa,T.: "Measurement of tympanic temperature and its significance in physiology and pathophysiology." Abstracts,Int.Symp.on Advanced Techniques and Clinical Applications in Biomedical Thermology. 13 (1993)
[Publications] Ogawa,T.: "Bilateral differences in tympanic temperatures reflects that in brain temperature." Temperature Regulation-Recent Physiological and Pharmacological Advances-. 127-131 (1993)
[Publications] 西田元彦: "開頭術後における頭蓋内温・鼓膜温・食道温の経過" 第46回日本自律神経学会総会抄録. 99 (1993)
[Publications] 篠田憲彦: "皮膚圧及びハリによる皮膚温分布の変化について-サーモグラフの画像処理による検討-" 日本生気象学会雑誌. 30. 148 (1993)
[Publications] Muramoto,K.: "Rat amygdaloid neuron responses during auditory discrimination." Neurosci.52. 621-636 (1993)
[Publications] Fukuda,M.: "Amygdala-hypothalamic control of feeding behavior in monkey:single cell responses before and after reversible blockade of temporal cortex or amygdala projections." Behav.Brain Res.55. 233-241 (1993)
[Publications] Fukuda,M.: "Neuronal responses in monkey anterior putamen during operant bar-press behavior." Brain Res.Bull.32. 227-233 (1993)
[Publications] Ono,T.: "Monkey hippocampal neuron responses related to spatial and non-spatial influence." Neurosci.Lett.159. 75-78 (1993)
[Publications] Hori,T.: "SART stress effects on lymphocytes in the thymus and spleen of normal,adrenalectomized,and sympathectomized mice." Clin.Immunol.Immunopathol.68. 243-255 (1993)
[Publications] Ono,T.: "Monkey hippocampal neurons related to spatial and nonspatial functions." J.Neurophysiol.70. 1516-1529 (1993)
[Publications] Nishijo,H.: "Rat amygdalar neuronal responses to gustatory and multimodal stimulation." Proc.of 26th Jpn.Symp.Taste&Smell. 101-104 (1993)
[Publications] Nishijo,H.: "Localization of dipole by boundary element method in three dimensional reconstructed monkey brain." Brain.Res.Bull.33. 225-230 (1994)
[Publications] Hayashi,N.: "Dipole tracing of monkey somatosensory evoked potentials." Brain.Res.Bull.33. 231-235 (1994)
[Publications] Ono,T.: "Central function in preference for amino acids." Olfaction and Taste XI,Spring er-Verlarg.(in press).
[Publications] Nishijo,H.: "Amygdalar neuronal responses to taste and other sensory stimuli in awake rats." Olfaction and Taste XI,Spring er-Verlarg.(in press).
[Publications] Tabuchi,E.: "Lateral hypothalamic neuron response to application of amino acids in defferent nutritive conditions." Olfaction and Taste XI,Spring er-Verlarg.(in press).
[Publications] 宮本雅之: "脳梗塞における睡眠時無呼吸症候群とその発現機序" 獨協医学会雑誌. 9. (1994)
[Publications] 山崎薫: "知的機能障害患者における事象関連電位に伴う各種自律神経反応の検討" Therapeutic Research. 14(6). 374-377 (1993)
[Publications] 山崎薫: "事象関連電位に伴う各種自律神経反応の検討" 日本臨床生理学会. 23-1. 1-10 (1993)
[Publications] 市丸雄平: "睡眠と血圧変動" 血圧モニタリングの臨床. 56-61 (1993)
[Publications] 市丸雄平: "自律神経障害と24時間血圧" Modern Physician. 13-8. 1175-1183 (1993)
[Publications] Tada,K.: "THE RELATIONSHIP BETWEEN EEG CHANGES AND HEMODYNAMIC PARAMETERS DURING DROWSINESS PERIOD" Sleep Research. 22. 29 (1993)
[Publications] Ichimaru,Y.: "MOVING CROSS CORRELATION ANALYSIS BETWEEN BLOOD PRESSURE AND HEART RATE DURING SLEEP APNEA" Sleep Research. 22. 211 (1993)
[Publications] Kanosue,K.: "Hypothalamic network for thermoregulatory shivering." Am.J.Physiol.(Reg.Integ.Comp.Physiol.).(in press). (1994)
[Publications] Kanosue,K.: "Hypothalamic network for thermoregulatory vasomotor control." Am.J.Physiol.(Reg.Integ.Comp.Physiol.).(in press). (1994)
[Publications] 斎藤博: "進行性polyneuropathyにおける縮瞳反応異常と瞳孔径について症例の経時的観察と文献41例関する分析" 神経眼科. 10. 325-331 (1993)
[Publications] 斎藤博: "プレドニゾロン服用後に症状の軽減・消失を示したRaeder症候群" 神経眼科. 10. 360-364 (1993)
[Publications] Kurosawa,M.: "Innocuous mechanical stimulation of the hindlimb skin increases extracellular release of acetylcholine in the cerebral cortex in conscious rats." Biogenic Amines.(in press).
[Publications] 久留聡: "脳血管障害患者における血圧調節機能" 臨床神経学. 33. 1416 (1993)
[Publications] 久留聡: "大脳半球障害と自律神経機能-脳血管障害患者について-" 第46回日本自律神経学会総会抄録. 113 (1993)
[Publications] Hirai,A.: "Effect of food intake on skin vasomotor responeses to headup tilt in humans." Jpn.J.Aerospace Environ.Med.30(1). 27-29 (1993)
[Publications] Hirashita,M.: "Relationship between heat loss responses and body core temperature during hyperthermia in humans." Jpn.J.Biometeor.30(1). 33-38 (1993)
[Publications] Hirashita,M.: "Contributions of body core and mean skin temperatures to the control of forehead sweating rate in humans." Jpn.J.Biometeor.30(1). 43-45 (1993)
[Publications] 田辺実: "運動時の前腕の皮膚血流量と発汗量の関係" 体力科学. 41(5). 516-517 (1993)
[Publications] Yamamoto,K.: "Muscle sympathetic outflow in Buerger′s disease." Journal of Autonomic Nervous System. 44. 67-76 (1993)
[Publications] Okamoto,T.: "Different thermal dependency of cutaneous sympathetic outflow to the glabrous and hairy skin in humans." Eur.J.Appl.Physiol.in press.
[Publications] Kihara,M.: "Assessment of sudomotor dysfunction in early Parkison′s disease." Eur-Neurol. 33(5). 363-365 (1993)
[Publications] 斎藤博: "自律神経の基礎と臨床in発汗の病態と検査法-温熱発汗と味覚発汗-" 医歯薬ジャーナル社,東京, 200-211 (1993)
[Publications] 高橋昭: "自律神経の基礎と臨床in中枢よりみた自律神経疾患の新しい概念" 医歯薬ジャーナル社,東京, 236-247 (1993)

1993 Fiscal Year Annual Research Report

自律神経機能の左右差発現

Principal Investigator

小川 徳雄 愛知医科大学, 医学部, 教授 (50065520)

Research Products

[Publications] 小川徳雄: "発汗活動の生理的・病的変化と自律神経" 東京女子医大雑誌. 63. 56-61 (1993)

[Publications] 小川徳雄: "脳温の左右差の生理的・病態生理的発現" 日本病態生理誌. 1. 12 (1993)

[Publications] 西田元彦: "脳血管障害と鼓膜温" 日本病態生理誌. 1. 30 (1993)

[Publications] Ogawa,T.: "Bilateral differences in tympanic temperatures induced by vascular compression in the head and neck." Jpn.J.Physiol.Supple.2. 786 (1993)

[Publications] Ogawa,T.: "Thermoregulatory responses of old men to gradual changes in ambient temperature." J.Therm.Biol.18. 345-348 (1993)

[Publications] Ogawa,T.: "Pulsatile sweating and sympathetic sudomotor activity." Jpn.J.Physiop. 43. 275-289 (1993)

[Publications] Ogawa,T.: "Effects of body and head positions on bilateral difference in tympanic temperatures." Eur.J.Appl.Physiol.67. 354-359 (1993)

[Publications] Ogawa,T.: "Measurement of tympanic temperature and its significance in physiology and pathophysiology." Abstracts,Int.Symp.on Advanced Techniques and Clinical Applications in Biomedical Thermology. 13 (1993)

[Publications] Ogawa,T.: "Bilateral differences in tympanic temperatures reflects that in brain temperature." Temperature Regulation-Recent Physiological and Pharmacological Advances-. 127-131 (1993)

[Publications] 西田元彦: "開頭術後における頭蓋内温・鼓膜温・食道温の経過" 第46回日本自律神経学会総会抄録. 99 (1993)

[Publications] 篠田憲彦: "皮膚圧及びハリによる皮膚温分布の変化について-サーモグラフの画像処理による検討-" 日本生気象学会雑誌. 30. 148 (1993)

[Publications] Muramoto,K.: "Rat amygdaloid neuron responses during auditory discrimination." Neurosci.52. 621-636 (1993)

[Publications] Fukuda,M.: "Amygdala-hypothalamic control of feeding behavior in monkey:single cell responses before and after reversible blockade of temporal cortex or amygdala projections." Behav.Brain Res.55. 233-241 (1993)

[Publications] Fukuda,M.: "Neuronal responses in monkey anterior putamen during operant bar-press behavior." Brain Res.Bull.32. 227-233 (1993)

[Publications] Ono,T.: "Monkey hippocampal neuron responses related to spatial and non-spatial influence." Neurosci.Lett.159. 75-78 (1993)

[Publications] Hori,T.: "SART stress effects on lymphocytes in the thymus and spleen of normal,adrenalectomized,and sympathectomized mice." Clin.Immunol.Immunopathol.68. 243-255 (1993)

[Publications] Ono,T.: "Monkey hippocampal neurons related to spatial and nonspatial functions." J.Neurophysiol.70. 1516-1529 (1993)

[Publications] Nishijo,H.: "Rat amygdalar neuronal responses to gustatory and multimodal stimulation." Proc.of 26th Jpn.Symp.Taste&Smell. 101-104 (1993)

[Publications] Nishijo,H.: "Localization of dipole by boundary element method in three dimensional reconstructed monkey brain." Brain.Res.Bull.33. 225-230 (1994)

[Publications] Hayashi,N.: "Dipole tracing of monkey somatosensory evoked potentials." Brain.Res.Bull.33. 231-235 (1994)

[Publications] Ono,T.: "Central function in preference for amino acids." Olfaction and Taste XI,Spring er-Verlarg.(in press).

[Publications] Nishijo,H.: "Amygdalar neuronal responses to taste and other sensory stimuli in awake rats." Olfaction and Taste XI,Spring er-Verlarg.(in press).

[Publications] Tabuchi,E.: "Lateral hypothalamic neuron response to application of amino acids in defferent nutritive conditions." Olfaction and Taste XI,Spring er-Verlarg.(in press).

[Publications] 宮本雅之: "脳梗塞における睡眠時無呼吸症候群とその発現機序" 獨協医学会雑誌. 9. (1994)

[Publications] 山崎薫: "知的機能障害患者における事象関連電位に伴う各種自律神経反応の検討" Therapeutic Research. 14(6). 374-377 (1993)

[Publications] 山崎薫: "事象関連電位に伴う各種自律神経反応の検討" 日本臨床生理学会. 23-1. 1-10 (1993)

[Publications] 市丸雄平: "睡眠と血圧変動" 血圧モニタリングの臨床. 56-61 (1993)

[Publications] 市丸雄平: "自律神経障害と24時間血圧" Modern Physician. 13-8. 1175-1183 (1993)

[Publications] Tada,K.: "THE RELATIONSHIP BETWEEN EEG CHANGES AND HEMODYNAMIC PARAMETERS DURING DROWSINESS PERIOD" Sleep Research. 22. 29 (1993)

[Publications] Ichimaru,Y.: "MOVING CROSS CORRELATION ANALYSIS BETWEEN BLOOD PRESSURE AND HEART RATE DURING SLEEP APNEA" Sleep Research. 22. 211 (1993)

[Publications] Kanosue,K.: "Hypothalamic network for thermoregulatory shivering." Am.J.Physiol.(Reg.Integ.Comp.Physiol.).(in press). (1994)

[Publications] Kanosue,K.: "Hypothalamic network for thermoregulatory vasomotor control." Am.J.Physiol.(Reg.Integ.Comp.Physiol.).(in press). (1994)

[Publications] 斎藤博: "進行性polyneuropathyにおける縮瞳反応異常と瞳孔径について症例の経時的観察と文献41例関する分析" 神経眼科. 10. 325-331 (1993)

[Publications] 斎藤博: "プレドニゾロン服用後に症状の軽減・消失を示したRaeder症候群" 神経眼科. 10. 360-364 (1993)

[Publications] Kurosawa,M.: "Innocuous mechanical stimulation of the hindlimb skin increases extracellular release of acetylcholine in the cerebral cortex in conscious rats." Biogenic Amines.(in press).

[Publications] 久留聡: "脳血管障害患者における血圧調節機能" 臨床神経学. 33. 1416 (1993)

[Publications] 久留聡: "大脳半球障害と自律神経機能-脳血管障害患者について-" 第46回日本自律神経学会総会抄録. 113 (1993)

[Publications] Hirai,A.: "Effect of food intake on skin vasomotor responeses to headup tilt in humans." Jpn.J.Aerospace Environ.Med.30(1). 27-29 (1993)

[Publications] Hirashita,M.: "Relationship between heat loss responses and body core temperature during hyperthermia in humans." Jpn.J.Biometeor.30(1). 33-38 (1993)

[Publications] Hirashita,M.: "Contributions of body core and mean skin temperatures to the control of forehead sweating rate in humans." Jpn.J.Biometeor.30(1). 43-45 (1993)

[Publications] 田辺実: "運動時の前腕の皮膚血流量と発汗量の関係" 体力科学. 41(5). 516-517 (1993)

[Publications] Yamamoto,K.: "Muscle sympathetic outflow in Buerger′s disease." Journal of Autonomic Nervous System. 44. 67-76 (1993)

[Publications] Okamoto,T.: "Different thermal dependency of cutaneous sympathetic outflow to the glabrous and hairy skin in humans." Eur.J.Appl.Physiol.in press.

[Publications] Kihara,M.: "Assessment of sudomotor dysfunction in early Parkison′s disease." Eur-Neurol. 33(5). 363-365 (1993)

[Publications] 斎藤博: "自律神経の基礎と臨床in発汗の病態と検査法-温熱発汗と味覚発汗-" 医歯薬ジャーナル社,東京, 200-211 (1993)

[Publications] 高橋昭: "自律神経の基礎と臨床in中枢よりみた自律神経疾患の新しい概念" 医歯薬ジャーナル社,東京, 236-247 (1993)

小川徳雄愛知医科大学, 医学部, 教授 (50065520)