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1994 Fiscal Year Final Research Report Summary

The Role of Radiation Therapy in The Treatment for Non-Small Cell Lung Cancer.

Research Project

Project/Area Number 05454298
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionGunma University School of Medicine

Principal Investigator

NIIBE Hideo  Gunma Univ.Sch.of Med.Radiol.& Radiat.Oncol.Professor, 医学部, 教授 (90008293)

Co-Investigator(Kenkyū-buntansha) NAKAJIMA Takashi  Gunma Univ.of Med.Radiol.& Rad.Oncol.2nd dpt.of Pathology, Professor, 医学部, 教授 (20124422)
YAMAKAWA Michitaka  Gunma Univ.of Med.Radiol.& Rad.Oncol.Assist.Prof., 医学部, 講師 (40182414)
SAITO Yoshihiro  Gunma Univ.of Med.Radiol.& Rad.Oncol.Instructor, 医学部, 助手 (50170543)
HAYAKAWA Kazushige  Gunma Univ.of Med.Radiol.& Rad.Oncol.Assist.Prof., 医学部, 講師 (70114189)
MITSUHASHI Norio  Gunma Univ.of Med.Radiol.& Rad.Oncol.Associate Prof., 医学部, 助教授 (20008585)
Project Period (FY) 1993 – 1994
KeywordsNon-small cell lung cancer / Radiation therapy / Radiosensitivity / Radiation-induced apoptosis / Combined modality / Prognostic factor / Optimal dose
Research Abstract

In the patients with unresectable stage III NSCLC received definitive radiation therapy (RT) at Gunma University Hospital from 1976 through 1989, the five year survival rates were 12% for stage IIIA and 8% for stage IIIB respectively. By histologic types, 14% were alive at five years for squamous cell carcinoma as compared with only 3% for other histologic types. Furthermore of the patients without progression of disease at the end of two years after RT,79% of squamous cell carcinoma patients were alive free of disease after 5 years from RT.However only 17% of adenocarcinoma patients lived longer than 5 years. Our results suggested that, in NSCLC patients, squamous cell carcinoma patients were most favorable candidate for definitive RT.Our analyzes of the factors affecting survival demonstrated that the performance status was significantly correlated to prognosis among host characteristics, and that, among tumor variables, N3 stage, thoracic bony invasion and malignant pleural effusion were unfavorable prognostic factors, and that tumor size and primary sites were the significant factors on survival. For the treatment factros of RT,the portal size given over 40 Gy, that should not exceed 100 cm^2, was correlated to survival. The optimal radiation doses for squamous cell carcinoma of the lung were considered to range from 60 to 70 Gy. our Biohistological studies using human lung cancer xenograft into the nude mice demonstrated the well correlation between radiation-induced apoptosis and radio-sensitivity.

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Hayakawa,K.: "Definitive radiation therapy for clinical Stage N0-N1 epidermoid carcinoma of the lung." J.Jpn.Soc.Ther.Radiol.Oncol.5. 261-269 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hayakawa,K.: "Effect of Krestin as adjuvant treatment on the prognosis after radical radiotherapy in patients with non-small cell cancer." Anticancer Research. 13. 1815-1820 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hayakawa,K.: "Adverse chronic effects of high-does irradiation on proximal bronchus in patients treated for bronchogenic carcinoma." The British Journal of Radiology. 66. 480-483 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki,T.: "High frequency of p53 abnormality in laryngeal cancers of heavy smokers and its relation to human papillomavirus infection." Jpn.J.Cancer Res.85. 1087-1093 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazumoto,T.: "Radioimmunodetection of lung cancer with IMACIS-1,I-131 labeled monoclonal antibodies to CEA and CA19-9." Annals of Nuclear Medicine. 7. 39-44 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mitsuhashi,N.: "Establishment and characterication of a new human lung poorly differentiated adenocarcinoma cell line,GLL-1,producing carcinoembryonic antigen (CEA) and CA19-9." Lung Cancer. (in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 新部英男(分担): "Annual Review 呼吸器1995" 中外医学社, 264 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hayakawa, K., Mitsuhashi, N., Saito, Y., Yamakawa, M., Nakayama, Y., Katano, S., Furuta, M., Niibe, H.: "Definitive radiation therapy for clinical stage N0-NI epidermoid carcinoma of the lung." J Jpn Soc Ther Radiol Oncol. 5 (4). 261-269 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hayakawa, K., Mitsuhashi, N., Saito, Y., Takahashi, M., Katano, S., Shiojima, K., Furuta, M., Niibe, H.: "Effect of Krestin (PSK) as adjuvant treatment on the prognosis after radical radiotherapy in patients with non-small cell lung cancer." Anticancer Res. 15 (3c). 1815-1820 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kazumoto, T., Mitsuhashi, N., Hayakawa, K., Yonome, I., Niibe, H.: "Radioimmunodetection of lung cancer with IMACIS-1, I-131 labeled monoclonal antibodies to CEA and CA19-9. Comparison of accumulation in irradiated and non-irradiated site" Ann Nuc Med. 7 (1). 39-44 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitsuhashi, N., Takahashi, T., Sakurai, H., Yamakawa, M., Hasegawa, M., Furuta, M., Matsumoto, H., Higuchi, K., Hayakawa, K., Niibe, H.: "Establishment and charac terization of a new human lung poorly differenciated adenocarcinoma cell line, GLL-1, producing carcinoembryonic antigen (CEA) and CA19-9" Lung Cancer. 12 (1,2) (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, T., Shidara, K., Hara, F., Makajima, T.: "High frequency of p53 abnormality in laryngeal cancers of heavy smokers and its relation to human papillomavirus infection" Jpn J Cancer Res. 85. 1087-1093 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hayakawa, K., Mitsuhashi, N., Saito, Y., Nakajima, N., Niibe, H.: "Adverse chronic effects of high-dose irradiation on proximal bronchus in patients treated for bronchogenic carcinoma" Br J Radiol. 66 (785). 477-479 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furuta, M., Hayakawa, K., Mitsuhashi, N., Saito, Y., Niibe, H.: "Second lung cancer following radiation therapy of locally advanced pulmonary cancer" Lung Cancer. 10 (3,4). 251-255 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saito, Y., Hayakawa, K., Mitomo, O., Nakayama, Y., Katano, S., Furuta, M., Mitsuhashi, N., Niibe, H.: "Radiation therapy after non-curative resection or exploration in non-small cell lung cancer" Jpn J Lung Cancer. 34 (4). 489-495 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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