1995 Fiscal Year Final Research Report Summary
Newlly Development and a Clinical Application of a Novel Preservation Solution for the lung (ET-Kyoto Solution)
| Project/Area Number |
05557064
|
|---|
| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | KYOTO UNIVERSITY |
|---|
Principal Investigator |
WADA Hiromi Kyoto University Chest Disease Research Institute, Thoracic Surgery, Associate Professor, 胸部疾患研究所, 助教授 (90167205)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUMON Tetsu Ajinomoto Co.Process Development Laboratory, Head Lab., プロセス開発研究所, 所長
YAMASITA Shunzo Roussel Morishita Co.Ltd.Research Laboratory., Staff Research Lab., 室長
SATO Makoto Roussel Morishita Co.Ltd.Research Laboratory., Head Research Lab., 所長
YOKOMISE Hiroyasu Kyoto University Chest Disease Research Institute, Thoracic Surgery, Staff, 胸部疾患研究所, 助手 (80231728)
INUI Kenji Kyoto University Chest Disease Research Institute, Thoracic Surgery, Staff, 胸部疾患研究所, 講師 (10193567)
|
|---|
| Project Period (FY) |
1993 – 1995
|
| Keywords | Trehalose / Lung preservation / Lung transplantation / Extracellular type solution / ET-Kyoto solution / IT-Kyoto solution / University of Wisconsin solution |
|---|
| Research Abstract |
Lung transplantation has been established as a successful therapeutic option for patients with end-stage lung diseases. However, the the wide spread application of this proedure is limited by the shortage of suitable donor lungs. To oversome this limitation, we developed a new extra or intracellular type solution, ET-Kyoto or IT-Kyoto solution, which contains 4.1% trehalose, gluconate, and hydroxyethyl starch (HES). Our results demonstrated that the function of the transplanted lung preserved with the ET-Kyoto solution for 20 hours was significantly better than those of lungs with IT-Kyoto or Euro-Collins solution. Our results also showed that the function of the transplanted lung preserved with the ET-Kyoto solution for 30 hours was significantly better than that of lungs with the University of Wisconsin solution. In this report, it was demonstrated definitely that the ET-K solution is a consistently excellent preservative solution. It is hoped that the result of this study will contribute to an increase in the supply of donor lungs and make semielective operations possible in the field of clinical lung transplantation.
|
Research Products
(22 results)
-
-
-
-
-
-
-
-
-
-
-
-
[Publications] Hirata, T., Yokomise, H., Fukuse, T., Muro, K., Inui, K., Yagi, K., Hitomi, S., and Wada, H.: "Effects of Trehalose in Preservation of Canine Lung for Transplants." Thoracic Cardiovascular Surgeon.41. 59-63 (1993)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Fukuse, T., Hirai, T., Yokomise, H., Hasegawa, S., Hirai, T., Muro K., Inui K., Hitomi, S., Wada, H.: "Combined Therapy with FK-506 and Cyclosporine-A for Canine Lung Allotransplantation ; Immunosuppressive Effects and Blood Trough Levels." J Heart and Lung Transplant. 12. 941-947 (1993)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Hirata, T., Fukuse, T., Liu, C., Muro, K., Yokomise, H., Yagi, K., Inui, K., Hitomi, S., and Wada, H.: "Effects of trehalose in canine lungpreservation." Surgery.115. 102-107 (1994)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Bando, T., Kosaka, S., Liu, C.J., Hirai, T., Hirata, T., Yokomise, H., Yagi, K., Inui, K., Hitomi, H., Wada, H.: "Effect of newly developed solutions containing trehalose on 20-hour canine lung preservation." J Thoracic Cardiovascular Surgery. 108. 92-98 (1994)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Fukuse, T., Hirata, T., Yokomise, H., Inui, K., Hitomi, S., Mitsui, A., Hirakawa, T., Yodoi, J., Wada, H.: "Attenuation of ischaemia-reperfusion injury by human thioredoxin." Thorax. 50. 387-391 (1995)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Ono, N., Yokomise, H., Muro, K., Go, T., Inui, K., Hitomi, S., Yodoi, J., Wada, H.: "Expression of Adult T-Cell Leukemia Derived Factor (ADF) in Bronchoalveolar Lavage Cells after Canine Lung Transplantation." J Thoracic Cardiovascular Surgery. 110. 15-21 (1995)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Liu, C.J,Bando, T.Hirai, T., Hirata, T., Yagi, K., Yokomise, H., Inui, K., Hitomi, S., Wada, H.: "Improved 20-hour Canine Lung Preservation With a New Solution-ET-Kyoto Solution." Eur J Cardio-thorac Surg. 9. 548-552 (1995)
Description
「研究成果報告書概要(欧文)」より
-
-
[Publications] Wada H., Muro, K., Ono N., Hirata T., Go, T., Yodoi, J., Hitomi, S.: "Rejection and Expression of Thioredoxin in Transplanted Canine Lung" Chest. 108. 810-814 (1995)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Wada, H., Liu, CJ., Yokomise, H., Inui, K., Fukuse, T., Hirata, T., .Hitomi, S.: "Newly developed preservation solution for the lung--30-hour preservation with newET-Kyoto solution--" Transplantation Proceeding. (in press). (1995)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Liu, C.J,Kosaka, S., Ueda, M., Hirata, T., Fukuse, T., Yokomise, H., Inui, K., Hitomi, S., Wada, H.: "Effects of new ET-Kyoto solution in 30 hours canine lung preservation" Transplantation Proceeding. (in press). (1995)
Description
「研究成果報告書概要(欧文)」より
