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1994 Fiscal Year Final Research Report Summary

FUNDAMENTAL AND PRACTICAL STUDIES OF DERMAL PATCH ANESTHESIA

Research Project

Project/Area Number 05557069
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKUMAMOTO UNIVERSITY

Principal Investigator

KANO Tatsuhiko  KUMAMOTO UNIVERSITY HOSPITAL ASSOCIATE PROFESSOR, 医学部・附属病院, 助教授 (50040605)

Co-Investigator(Kenkyū-buntansha) MISHIMA Motohiro  DAIICHI COLLEGE OF PHARMACEUTICAL SCIENCE INSTRUCTOR, 講師 (70190626)
IKUTA Yoshihiro  KUMAMOTO UNIVERSITY HOSPITAL ASSISTANT, 医学部・附属病院, 助手 (90264308)
SAKAMOTO Masakatsu  KUMAMOTO UNIVERSITY HOSPITAL ASSISTANT, 医学部・附属病院, 助手 (70196103)
HIGASHI Kanemitsu  KUMAMOTO UNIVERSITY HOSPITAL ASSISTANT, 医学部・附属病院, 助手 (40238267)
Project Period (FY) 1993 – 1994
KeywordsDERMAL PATCH ANESTHESIA / ABSORPTION PROMOTER / LIDOCAINE GEL
Research Abstract

(1) We have developed a transdermally applicable 10% lidocaine gel with 3% glycyrrhetinic acid monohemiphthalate disodium (GAMPh 2Na) as an absorption promoter.
(2) The effect of 3% GAMPh 2Na as an absorption promoter was confirmed in a double blind human study.
(3) Venous cannulation was carried out without pain in 65.5% of the adult patients and 82.4% of children after about 60 min of application.
(4) The blood concentration of lidocaine after transdermal application of 0.3g of the gel to healthy volunteers was less than 0.01mu/ml.
5) The lidocaine gel patch was as potent or slightly more potent in producing local skin analgesia as the EMLA cream patch.
6) The lidocaine gel treatment was useful for reduction of pain associated with acute or subacute phase of herpes zoster.
7) Besides enhancement of transdermal absorption, GAMPh 2Na suppressed cutaneous vasodilation induced by transdermally absorped lidocaine.
8) Skin pretreatments, such as stripping with gum tape or cleaning with benzene, shortened the latency time of the dermal patch anesthesia.
9) In addition to the transcellular main roots, some of the transcutaneously applied gel penetrated deeply into the skin through the appendageal roots such as the eccrine sweat glands and the pilo-sebaceous glands.

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Sakamoto M,et al: "Dermal patch anlsthesia:Comparison of 3% GAμHPh-10%lidocainl gel and EMLA cream" Analsthesia. 48. 390-392 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kano T,et al: "Evaluation of the plnetration depth of transdermally applied 3% GAμHph-10% lidocainl gel in man" J Anesth. 7. 21-26 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura M et al: "Dlrmal patch anlsthesia with 10% lidocainl gel containing glycyrrhetinic acid monohlniphthalate disodium us an alosorption pronoter" Kumamoto Med J. 44. 111-122 (1993)

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      「研究成果報告書概要(和文)」より
  • [Publications] 志茂田 治,ほか: "10%リドカイン水性ゲルによる帯状疱疹痛の管理" 麻酔. 42. 1171-1176 (1993)

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      「研究成果報告書概要(和文)」より
  • [Publications] 中野 眞汎,ほか: "皮膚表面麻酔" 臨床麻酔. 17. 617-622 (1993)

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      「研究成果報告書概要(和文)」より
  • [Publications] 盛山 恭子,ほか: "貼付型局所麻酔薬リドカインゲルの局所皮膚血流への影響" 臨床麻酔. 18. 1205-1208 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakamoto M,Kano T.Sadanaga M,Morioka T,Mishima M,Nakano M: "Dermal patch anesthesia : Comparison of 3% GAMHPh-10% lidocaine gel and EMLA cream." Anaesthesia. 48. 390-392 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kano T,Nakamura M,Hashiguchi A,Masuda K,Morioka T,Mishima M,Nakano M: "Evaluation of the penetration depth of transdermally applied 3% GAMHPh-10% lidocaine gel in man" J Anesth. 7. 21-26 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura M,Kano T,Sakamoto M,Shimoda O,Morioka T,Mishima M,Nakano M: "Dermal patch anesthesia with 10% lidocaine gel containing glycyrrhetinic acid monohemiphthalate disodium as an absorption promoter." Kumamoto Med J. 44. 111-122 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimoda O,Kano T,Takagi M,Tajima T,Tashiro M,Ikuta Y,Morioka T,Nakano M,Mishima M: "Transdermal application of 10% lidocaine-gel for management of pain associated with herpes zoster." Jpn J Anesth (Masui). 42. 1171-1176 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakano M,Kano T: "Skin surface anesthesia" J Clin Anesth (Rinshoumasui). 17. 617-622 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Moriyama K,Endou F,Higashi K,Kano T,Nakano M,Kobayashi K: "Effects of transdermal 10% lidocaine gel with and without glycyrrhetinic acid monohemiphthalate disodium on the human local skin blood flow" J Clin Anesth (Rinshoumasui). 18. 1205-1208 (1994)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Iwatani N,Kodama M,Miike T,Kano T,Nakano M,Mishima M,Tsuzuki O: "Dermal anesthesia using a lidocaine gel patch for pain of human growth hormone (hGH) self-injection and relief of anxiety" Clin Pediatr Endocrinol. 3. 113-116 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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