• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1994 Fiscal Year Final Research Report Summary

Kaposi's sarcoma, proliferation and regression

Research Project

Project/Area Number 05670177
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionUniversity of the Rykyus

Principal Investigator

IWAMASA Teruo  University of the Ryukyus School of Medicine Professor, 医学部, 教授 (10110842)

Co-Investigator(Kenkyū-buntansha) MAKINO Yoshihiro  University of the Ryukyus Dept.Virol., 医学部, 助教授 (60039930)
HOSAKAWA Atsushi  University of the Ryukyus Dept.Dermatol, 医学部, 講師 (10181497)
NAKAZATO Iwao  University of the Ryukyus Dept.Pathol., 医学部, 助手 (90244318)
Project Period (FY) 1993 – 1994
Keywordskaposi's sarcoma / Growth factor / Endothelial cell / Tissue culture
Research Abstract

BACKGROUND :
Although Kaposi's sarcoma is documented as being rare in mainland Japan, we have several patients with Kaposi's sarcoma in Okinawa including classical type and AIDS associated type.
Using these Kaposi's sarcoma cells, tumor cell culture was performed. The aims of the present study are as follows : (1) . Characterization of the Kaposi's sarcoma cell. (2) . Detection of the growth factor of Kaposi's sarcoma cell.
METHODS :
Tumor cell culture was performed using the type I collagen three-demensional culture and collagen uncoated plate culture methods. Minimum essential medium (MEM) containing 20% fetal bovin serum (FBS) and heparin were used as culture medium. The endothelial growth factor supplement (ECGS) and IL-6, etc are tested. The morphological investigation and immunohistochemical studies were also performed.
RESULTS :
1). The AIDS Kaposi's sarcoma cells growth was observed by use of Oncostain M.But classical Kaposi's sarcoma cell proliferation was not stimulated by Oncostattin M and also the condition media of T-lymphocyte culture which were infected with HTLV-2. Any of well known growth factors has not effect on the classical Kaposi's sarcoma cell culture.
2).The Kaposi's sarcoma cells showed the endothelial cell characteristics immunohistochemically.

  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] Teruo Iwamasa: "Epidemic and non-epidemic Kaposi's sarcoma:Diagnosis,staging and treatment" Critical Review in Oncology/Hematology. (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩政輝男 他2名: "部検例からみた日本のエイズ" 小池盛雄,倉田毅,森茂郎, 127 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Teruo Iwamasa: "Epidemic and non-epidemic Kaposi's sarcoma : Diagnosis, staging and treatment" Critical Review in Oncology/Hematology. (1995)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1996-04-15  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi