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1994 Fiscal Year Final Research Report Summary

Study on hemocompatibility and antithrombotic characeristics of the small caliver vascular prosthesis

Research Project

Project/Area Number 05670980
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

SAKUMA Makoto  Hokkaido Univ., Medical Hospital., Associate Professor, 医学部・附属病院, 助教授 (70170636)

Co-Investigator(Kenkyū-buntansha) MATSUI Yoshiro  Hokkaido Univ., Medical Hospital., Associate Professor, 医学部・附属病院, 助教授 (90219379)
YASUDA Keishu  Hokkaido Univ., Medical Hospital., Professor, 医学部・附属病院, 教授 (60125359)
Project Period (FY) 1993 – 1994
Keywordsvascular prosthesis / hemocompatibilitiy / antithrombotic property / fibronectin / collagen coated graft
Research Abstract

The objective of this study was to evaluate the effects of fibronectin, collagen and insulin covalent immobilization on early patency, hemocompatibility and healing of small caliber vascular prostheses. Six fibronectin, collagen and insulin coated ePTFE grafts and six untreated ePTFE grafts were implanted into the carotid artery in 6 mongrel dogs. The grafts were 30micrometer in fibril length, 4mm in diameter. Observation was performed at 1day, 7day, 4week, 16week after implantation. The patency rates of the grafts were 66% for covalent graft and 75% for untreated graft. There was no significant difference among the two groups. But fibronectin, collagen and insulin covalent grafts demonstrated fibroplastic change and proliferation of smooth muscle cells near the anastomotic sites. In conclusion, the results suggest that fibronectin, collagen and insulin covalent grafts is useful for promoting fraft healing, and does not diminish anti thrombogenecity.

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 西部 俊哉: "フィブロネクチン共有結合固定人工血管の実験的研究" 日本血管外科学会雑誌. 5. 177-182 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 西部 俊哉: "多孔質セグメント化ポリウレタン人工血管の長期移植成績" 日本血管外科学会雑誌. 4. 643-649 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] NISHIBE,T.: "Effects of fibronectin covalent immobilization on early patency and graft healing of small caliber expanded Polytetrafluoroethylene grafts." Jpn.J.Vasc.Surg.5. 177-182 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] NISHIBE,T.: "Long term results of an experimental study of small caliber segmentedpolyurethane grafts." Jpn.J.Vasc.Surg.4. 643-649 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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