1995 Fiscal Year Final Research Report Summary

Effects of nm23 on intrahepatic metastasis of the hepatocellular carcinoma

Research Project

Project/Area Number	05671007
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	General surgery
Research Institution	Okayama University
Principal Investigator	HAMAZAKI keisuke Okayama University, Medical School, Assistant Professor, 医学部・附属病院, 講師 (90172965)
Co-Investigator(Kenkyū-buntansha)	NAOMOTO Yoshio Okayama University, Medical School, Assistant, 医学部・附属病院, 助手 (00237190) NAMBA Nasayoshi Okayama University, Medical School, Professor, 医学部, 教授 (80069004)
Project Period (FY)	1993 – 1995
Keywords	nm23 / metastasis / c-myc
Research Abstract	Increased nm23 gene expression has been reported to reduce metaplastic potential in breast carcinoma. In contrast, there are several report that the expression of nm23 increases following the tumor progression in colon adenocarcinoma and lung adenocarcinoma. We have transfected rat nm23 cDNA into mouse adenoma cells-Colon26. Overexpression of c-myc and significant reduction of metastatic potential were observed in the clone of transfected nm23. But there was no significant correlation between nm23 expression and cell growth.