1994 Fiscal Year Final Research Report Summary
DEVELOPMENT OF AN OXYGENATOR WITH BUILT-IN HEMOCONCENTRATOR
| Project/Area Number |
05671140
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Tokyo Women's Medical College |
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Principal Investigator |
NISHIDA Hiroshi TOKYO WOMEN'S MEDICAL COLLEGE,CARDIOVASCULAR SURGERY ASSISTANT PROFESSOR, 医学部, 講師 (50147427)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAZAWA Arifumi TOKYO WOMEN'S MEDICAL COLLEGE,CARDIOVASCULAR SURGERY ASSISTANT, 医学部, 助手 (40201595)
ENDO Masahiro TOKYO WOMEN'S MEDICAL COLLEGE,CARDIOVASCULAR SURGERY PROFESSOR, 医学部, 教授 (20075302)
KOYANAGI Hitoshi TOKYO WOMEN'S MEDICAL COLLEGE,CARDIOVASCULAR SURGERY CHAIRMAN AND PROFESSOR, 医学部, 主任教授 (90138884)
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| Project Period (FY) |
1993 – 1994
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| Keywords | membrane oxygenator / hemoconcentrator / hollow fiber / blood outside flow mode |
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| Research Abstract |
In order to simplify the extracorporeal blood circuit and to facilitate handling of cardiopulmonary bypass, we have combined a hollow fiber unit for gas exchange and that for hemofiltration in one component and developed a new membrane oxygenator with a function of hemoconcentrator. The cylindrical device is consisted of a hollow fiber for hemofiltration with another fiber for gas exchange provided outside. Both of them adopt the blood outside perfusion system, Blood flows from around the center core towards the hollow fiber around it, first hemoconcentrator and then oxygenator, in radial direction. By applying this flow mode, even distribution of blood flow to the entire fiber was realized and the performance of the device was improved. Oxygen transfer rate was 336 ml/min at a flow rate of 6 L/min, and ultrafiltration rate was 7 L/hour with a flow rate of 4 L/min with a hematocrit of 25%. Pressure drop of the whole unit was only 60 mmHg with a flow rate of 6 L/min. The combined structure of the two units has not caused any adverse effects. In conclusion, by combining an oxygenator and a hemoconcentrator, excellent and simplified hemoconcentration is made available as the blood outside flow mode is adopted.
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