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1994 Fiscal Year Final Research Report Summary

Cochlear blood flow in sudden deafness

Research Project

Project/Area Number 05671424
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionNagoya University

Principal Investigator

NAKASHIMA Tsutomu  Dept.of Otorhinolaryngology Associate Professor Nagoya University School of Medicine, 医学部, 助教授 (30180277)

Co-Investigator(Kenkyū-buntansha) YANAGITA Noriyuki  Dept.of Otorhinolaryngology Professor Nagoya University School of Medicine, 医学部, 教授 (00023804)
Project Period (FY) 1993 – 1994
KeywordsCochlear blood flow / Sudden deafness / Perilymphatic fistula / Laser Doppler flowmetry / Carbon dioxide / 二酸化炭素
Research Abstract

Impairment of cochlear blood flow may be one of the factors implicated in the pathophysiology of sudden deafness. Cochlear blood flow in sudden deafness was measured in nine patients who were suspected of having perilymphatic fistulas. During exploratory tympanotomy, the tip of a laser-Doppler probe was attached to the promontory near the anterior portion of the round window niche. The distance between the exciting and receiving optic fibers was increased to elevate the maximum depth sensitivity. In all nine patients, pulsatory movement of the laser output that corresponded to ECG was observed. We attempted to measure effects of carbon dioxide on cochlear blood flow, such as inhalation of carbogen and cessation of respiration. In almost cases, however, no significant change of cochlear blood flow was observed by these procedures.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Nakashima T,Yanagita N.: "Outcome of sudden deafness with and without vertigo" Laryngoscope. 103. 1145-1149 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中島務: "膜迷路血管の周辺環境と血流" Otology Japan. 3. 734-738 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakashima T,Yanagita N et al.: "Comparative study on sudden deafness by two nationwide epidemiological surveys in Japan" Acta Otolaryngol (Stockh). Suppl 514. 14-16 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 森崎博伸,中島務,柳田則之: "脳循環・代謝改善剤の蝸牛血流への影響" 日耳鼻. 97. 1393-1405 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中島務: "外リンパ瘻" 耳鼻臨床. 87. 1608-1609 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakashima T er al.: "Effects of vasodilating agents on cochlear blood flow in mice." Hearing research. 80. 241-246 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakashima T,Yanagita N: "Outcome of sudden deafness with and without vertigo." Laryngoscope. 103. 1145-1149 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakashima T: "Effects of inner ear fluid on cochlear blood flow." Otology Japan. 3. 734-738 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakashima T,Yanagita N et al.: "Comparative study on sudden deafness by two nationwide epidemiological surveys in Japan." Acta Otolaryngolo (Stockh). Suppl.514. 14-16 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morisaki H,Nakashima T,Yanagita N.: "The effects of cerebral metabolic activator and vasodilator on cochlear blood flow." Nipponjibiinkokagakkaikaiho (J.of Otolaryngology of Japan). 97. 1393-1405 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakashima T: "Perilymphatic fistula." Practica Otologica (Kyoto). 87. 1608-1609 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakashima T et al.: "Effects of vasodilating agents on cochlear blood flow in mice." Hearing Research. 80. 241-246 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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