1994 Fiscal Year Final Research Report Summary
THE STUDY OF CHEMICAL MEDIATORS,HISTAMINE AND LEUKOTRIENS IN THE PATIENTS WITH ALLERGIC RHINITIS AFTER ANTIGEN CHALLENGE
Project/Area Number |
05807160
|
Research Category |
Grant-in-Aid for General Scientific Research (C)
|
Allocation Type | Single-year Grants |
Research Field |
Otorhinolaryngology
|
Research Institution | THE JIKEI UNIVERSITY SCHOOL OF MEDICINE |
Principal Investigator |
NAGAKURA Hitoshi THE JIKEI UNIVERSITY SCHOOL OF MEDICINE,OTOLARYNGOLOGY,ASSISTANT, 医学部, 助手 (90211440)
|
Co-Investigator(Kenkyū-buntansha) |
WAKAMORI Kazuo THE JIKEI UNIVERSITY SCHOOL OF MEDICINE,OTOLARYNGOLOGY,ASSISTANT, 医学部, 助手 (30201148)
|
Project Period (FY) |
1993 – 1994
|
Keywords | nasal allergy / antigen challenge / Histamine / Leukotriene / early response / provocation test |
Research Abstract |
The purpose of this study is to evaluate the role of chemical mediators after antigen challenge. Clinical effects of medication, including antihistamine and antiallergic drug in the treatment of nasal allergy, were evaluated according to patient's symptom score, such as, sneezing, nasal obstruction and rhinorrhea. In our country, the clinical efficacy of medications on allergic rhinitis depend on doctor's judgment and patient's impression, therefore, more objective method should be required. We have evaluated the measurement of chemical mediators in nasal lavage in 21 patients. The antigen challenge was performed by antigen discs on bilateral inferior turbinate for 10 minutes. Nasal lavage fluid were collected before and after antigen challenge, by washing with 40 ml of saline. The amount of histamine and leukotrienes in nasal lavage increased significantly on the early responses. Antiallergic drug, ketotifen, sprayd topically over the nasal mucosa, 4 times a day, for 2 weeks, inhibited chemical mediators in some cases. These deta suggest the clinical effect of antiallergic drugs in the treatment of nasal allergy.
|