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1996 Fiscal Year Final Research Report Summary

General Studies on Special Cancer Research

Research Project

Project/Area Number 06042021
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

TOMINAGA Suketami  Aichi Cancer Center Research Institute, 所長 (30124530)

Co-Investigator(Kenkyū-buntansha) FUJIYAMA Chihaya  Kagoshima University School of Medicine, 医学部・公衆衛生学教室, 助手 (30274814)
IKEDA Noriaki  Department of Oral & Maxillofacial Surg. (II), Aichigakuin University, 歯学部・口腔外科学第2講座, 講師 (30150791)
SASAKI Ryuichiro  Department of Public Health, Aichi Medical University, 公衆衛生学教室, 教授 (80131241)
ICHIHASHI Masamitsu  Kobe University School of Medicine, 医学部・皮膚科学講座, 教授 (00030867)
SHIMIZU Hiroyuki  Department of Public Health, Gifu University School of Medicine, 医学部・公衆衛生学教室, 教授 (90073139)
TAJIMA Kazuo  Division of Epidemiology, Aichi Cancer Center Research Institute, 疫学部, 部長 (30150212)
YOSHIMURA Takesumi  Institute of Industrial Ecological Sciences University of Occupational and Envir, 産業生態科学研究所, 教授 (20037435)
OHNO Yoshiyuki  Department of Preventive Medicine, Nagoya University School of Medicine, 医学部・予防医学教室, 教授 (10160590)
FUJIKI Hirota  Saitama Cancer Center Research Institute, 所長 (60124426)
HIROHASHI Setsuo  National Cancer Center Research Institute, 副所長 (70129625)
YOSHIDA Mitsuaki  Institute of Medical Science, University of Tokyo, 医科学研究所, 所長 (80012607)
YAMAMOTO Tadashi  Institute of Medical Science, University of Tokyo, 制癌研究部, 教授 (40134621)
KUROKI Toshio  Institute of Molecular Oncology, Showa University, 腫瘍分子生物学研究所, 所長 (90006073)
KITAGAWA Tomoyuki  The Cancer Institute, 所長 (50085619)
Project Period (FY) 1994 – 1996
KeywordsCancer / Stomach cancer / Esophageal cancer / Liver cancer / Skin cancer / China / South-East Asia / Central-South America
Research Abstract

This study group has been functionning as a planning and coordinating group of all the Special Cancer Research. The major activities of this study group is as follows :
1) To conduct pilot studies on cancer research in both developed and developing countries and to evaluate the feasibility and prospects of future studies on cancer. In fiscal years 1994-1996,5 pilot sutdies have been conducted ;
(1) Comparative epidemiology on stomach and esophageal cancers in China.
(2) Epidemiological study on nutrition and oral cancer in Malaysia.
(3) Study on risk factors of skin cancer in Indonesia.
(4) Epidemiological study on EB virus infection an stomach cancer in Hong Kong, Thailand and Malaysia.
(5) Epidemiological study on nutrition (especially, fat intake) and cancer in Mediterranean countries (Greece and France).
All of the 5 pilot studies were regarded as feasible and fruitful and (1) and (2) were graded up to regular planned studies. (3) is expected to be feasible and will be graded up to a planned regular study nexy year. (4) and (5) were regarded as feasible, but more information and preparations were needed to be graded up to regular planned studies. Thus, the two pilot studies will be continued in the next year.
2) To select and propose priority planned studies on cancer considering the results of pilot studies. In fiscal year 1994-1996,15 planned studies were were selected and proposed.
3) To hold meetings of chief investigators to review progress of each study and to discuss problems in conducting international collaborative studies.
The meeting was held once a year in the end of fiscal year (middle of March).
4) To hold a symposium to report major results of the selected topics once a year in conjunction with the meeting of chief investigators.
5) To distribute information on special cancer research through news letters to all related investigators. The news letter was published three times a year.

  • Research Products

    (155 results)

All Other

All Publications (155 results)

  • [Publications] 富永祐民: "日本の癌,世界の癌-最近の動向" 癌と化学療法. 22. 1-8 (1995)

    • Description
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  • [Publications] Kawabuchi,B.: "Subcutaneous sarcomas of probable neuronal origin in a transgenic mouse strain conaining an albumin promoter-fused simian virus 40 large T angigen gene." Jpn.J.Cancer Res.85. 601-609 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto,N.: "Carcinogen daily dose-dependence of the viological features and development rate of hepatocellular carcinomas induced by 3'-methyl-4-dimethylaminoazabenzene in the rat." Cancer Letters. 83. 59-68 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyasaka,K.: "Frequent loss of haterozygosity on chromosome 4 in diethyl-nitrosamine-induced C3H/HSM mouse hepatocellular carcinomas in culture" Molecular Carcinogenesis. 13. 37-43 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikuta,T.: "Cholesterol sulfate,a novel activator for the η isoform of protein kinase C." Cell Growth & Differentiation. 5. 943-947 (1994)

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  • [Publications] Kuroki,T.: "Evaluation of carcinogenic risks to humans : A list of the IARC." Jpn.J.Cancer Res.85. 1320-1321 (1994)

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  • [Publications] Umemori,H.: "Initial events of myelination involve Fyn tyrosine kinasesignaling." Nature. 367. 572-576 (1994)

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  • [Publications] Fujimoto,J.: "brt,a mouse gene encoding a novel receptor-type protein-tyrosine kinase,is preferentially expresed in the brain." Oncogene. 9. 693-698 (1994)

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  • [Publications] Suzuki,T.: "Tax protein of HTLV-1 interacts with the Re1 homology domain of NF-κB p65 and c-Re1 proteins bound to the NF-κB binding site and activates transcription." Oncogene. 9. 3099-3105 (1994)

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  • [Publications] Hirai,H.: "Tax pretein of human T-cell leukemia virus type 1 binds to the ankyrin motifs of inhibitory factor κB and induces nuclear translocation of transcription factor NF-κB proteins for transcriptional activation." Proc.Natl.Acad.Sci.USA. 91. 3584-3588 (1994)

    • Description
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  • [Publications] Furukawa,Y.: "HTLV-1 Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leulemia cells." Blood. 85. 1865-1870 (1995)

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  • [Publications] Kihana,T.: "Pregnostic significance of the overexpression of c-erbB-2 protein in adenocarcinoma of the uterine cervix." Cancer. 73. 148-153 (1994)

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  • [Publications] Tsuda,H.: "Allele loss on chromosome 16q24,2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extend of spread." Cancer Res.54. 513-517 (1994)

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  • [Publications] Tsuda,H.: "Association among p53 gene mutation,nuclear accumulation of the p53 protein and aggressive phenotypes in breast cancer." Int.J.Cancer. 57. 498-503 (1994)

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  • [Publications] Fujiki,H.: "Tumor necrosis factor-α,a new tumor promoter,enegendered bybiochemical studies of okadaic acid." J.Biochem.115. 1-5 (1994)

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  • [Publications] Fujiki,H.: "A new tumor promotion pathway and its inhibitors." Cencer Detection and Prevention. 18. 1-7 (1994)

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  • [Publications] Ohta,T.: "Nodularin,a potent inhibitor of protein phosphatases 1 and 2A,is a new environmental carcinogen in male F344 rat liver." Cancer Res.54. 6402-6406 (1994)

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  • [Publications] Tamakoshi,A.: "Serum cholesterol and cancer mortality in Japanese civil service workers : Findings from a nested case-control study." J.Epidemiol.3. 99-107 (1994)

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  • [Publications] Wakai,K.: "Risk factors for breast cancer among Japanese women in Tokyo : A case-control study." J.Epidemiol.4. 65-71 (1994)

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  • [Publications] 吉村健清: "もう1つの大久野島-旧毒ガス弾製造工場従事者の慢性気管支炎有病率-" 医学のあゆみ. 170. 950-951 (1994)

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  • [Publications] Washio,M.: "Hepatitis B surface antigen and antibody among chronic hemoodialysis patients in Fukuoka,Japan : A high risk for becoming hepatitis B virus carriers." J.Epidemiol.4. 99-102 (1994)

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  • [Publications] Zaninovic,V.: "Geographic independent of HTLV-I and HTLV-II foce in the Andes high land and the Carivean coast of Colombia" AIDS Res Human Reroviruses. 10. 97-101 (1994)

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  • [Publications] 柳生聖子: "女性における血清βカロチン値の変動に関する縦断的研究" 医学と生物学. 129. 29-33 (1994)

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  • [Publications] 伊藤宜則: "南北海道住民における血清カロチノイド、レチノール及びα-トコフェロール値と血清過酸化脂質値との関連性" ビタミン. 68. 351-363 (1994)

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  • [Publications] Tominaga,S.: "Epidemiology of breast cancer in Japan." Cancer Letter. 90. 75-79 (1995)

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  • [Publications] Miyasaka,K.: "Frequent loss of heterozygosity on chromosome 4 in diethyl-nitrosamine-induced C3H/HSM mouse hepatocellular carcinomas." Molecular Carcinogenesis. 13. 37-43 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki,T.: "Identification of an enhancer responsible for tumor marker gene expression by means of transgenic rats." Cancer Res.55. 2651-2655 (1995)

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  • [Publications] Prince Masahito: "Frequent development of pncreatic carcinomas in the Rana nigromaculata group." Cancer Res.55. 3781-3784 (1995)

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  • [Publications] Chida,K.: "Cholesterol sulfate,a second messenger for the η isoform of protein kinase C,inhibits promotional phase in mouse skin carcinogenesis." Cancer Res.55. 4865-4869 (1995)

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  • [Publications] Koike,M.: "Growth enhancement of normal human keratinocytes by the antisense oligonucleotide of retinoblatoma susceptibility gene." Oncogene. 10. 117-122 (1995)

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  • [Publications] Suzuki,T.: "Tax protein of HTLV-1 destabilizes the complexs of NF-κB and 1κB-α and induces nuclear translocation NF-κB for transcriptional activation." Oncogene. 10. 1199-1207 (1995)

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  • [Publications] Furukawa,Y.: "HTLV-1 Tax expressed at the same level in infected cells of HAM/TSP patients as in asymptomatic carriers but at a lower level in ATL patients." Blood.85. 1865-1870 (1995)

    • Description
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  • [Publications] Kanai,Y.: "c-erbB-2 gene product directly associates with B-catenin and plakoglobin." Biochem.Biophys.Res.Commun.208. 1067-1072 (1995)

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  • [Publications] Shimoyama,Y.: "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells." Cancer Res.55. 2206-2211 (1995)

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  • [Publications] Yoshimura,K.: "Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas." Rroc.Natl.Acad.Sci.USA. 92. 7416-7419 (1995)

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  • [Publications] Sueoka,E.: "Activation of protein kinase C by mycobacterian cord necrosis factor-α release in mouse lung tissues." Jpn.J.Cancer Res.86. 749-755 (1995)

    • Description
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  • [Publications] Suganuma,M.: "Tautomycin : an inhibitor of protein phosphatases 1 and 2A but not a tumor promoter on mouse skin and in rat glandular stomach." J.Cancer Res.Clin.Oncol.121. 621-627 (1995)

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  • [Publications] Ohno,Y.: "Initiation of international collaborative study on breast cancer between Japan and Indonesia." Medical Journal of Indonesia.4. 131-134 (1995)

    • Description
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  • [Publications] Budiningsih,S.: "Epidemiological analysis of risk factors for breast cancer in Indonesian females." Medical Journal of Indonesia. 4. 163-168 (1995)

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  • [Publications] Ohno Y.: "Tea consumption and lung cancer risk : A case-control study in Okinawa,Japan." Jpn.J.Cancer Res.86. 1027-1034 (1995)

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  • [Publications] Saku,M.: "Mortality in psychiatric patients,with a specific focus on cancer mortality associated with schizophrenia." International Journal of Epidemiology. 24. 366-372 (1995)

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  • [Publications] Ogura,C.: "Prevalence of senile dementia in Okinawa,Japan." International Journal of Epidemiology. 24. 373-380 (1995)

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  • [Publications] Takezaki,T.: "Incidence of human T lymphotoropic virus type I seroconversion after 40 among Japanese residents in an area where the virus is endemic." The Journal of Infectious Diseases. 171. 559-565 (1995)

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  • [Publications] Inoue,M.: "Protective factor against progression from atorophic gastritis to gastric cancer-data from a cohort study in Japan." Int.J.Cancer. 66. 309-314 (1996)

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  • [Publications] Inoue,M.: "Epidemiological features of first-visit outpatients in Japan : comparison with general population and variation by sex,age,and season." J.Clin.Epidemiol.50. 69-77 (1997)

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  • [Publications] Koo,L.C.: "Dietary and lifestyle correlates of passive smoking in Hong Kong,Japan,Sweden,and USA." Social Science and Medicine. in press (1997)

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  • [Publications] Tsunashima,K.: "A novel clonality assay for the mouse : appliciation to hepatocellular carcinomas induced with diethylnitrosamine." Molecular carcinogenesis. 15. 33-37 (1996)

    • Description
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  • [Publications] Koyama,Y.: "Lectin affinity electrophoretic demonstration of tissue specificity and malignant alteration of human α-fetoprotein isoforms produced in transgenic mice." Biocehmical and Biiophysical Research Communications. 223. 757-761 (1996)

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  • [Publications] Ishida,T.: "Intra-articular calcifying synovial sarcoma mimicking synovial chondromatosis." Skeletal Radiol.25. 766-769 (1996)

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  • [Publications] Kuroki,T.: "Report on the 5th Japanese-German workshop on molecular and cellular aspects of carcinogenesis." Intl.J.Cancer. 66. 1-5 (1996)

    • Description
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  • [Publications] Koike,M.: "DMSO induces apoptosis in SV40-transformed hu-man keratinocytes,but not in normal keratino-cytes." Cancer Letters. 108. 185-193 (1996)

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  • [Publications] Jia,L.-G.: "Screening the p53 status of human cell lines using a yeast functional assay." Mol.Carcinog.in press (1997)

    • Description
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  • [Publications] Murakami,A.: "Absence of down-regulation and translocation of the eta isoform of protein kinase C in normal human keratinocytes." J.Invest.Dermatol.106. 790-794 (1996)

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  • [Publications] Fujimoto,J.: "Characterization of the transforming activity of p80,a hyperphosphorylated protein in a ki-1 lymphoma cell line with t (2;5)." Proc.Natl.Acad.Sci.USA. 93. 4181-4186 (1996)

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  • [Publications] Iwahara,T.: "Molecular characterization of ALK,a receptor tyrosine kinase expressed specifically in the the nervous system." Oncogene. (in press). (1997)

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  • [Publications] Tezuka,T.: "Physical and functional association of the Cb1 proto-oncogene product with a Scr-family protein tyrosine kinase,p53/56 lyn,in the B cell antigen recoptor-mediated signaling." J.Exp.Med.183. 675-680 (1996)

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  • [Publications] Yoshida,M.: "Multiple targets of HTLV-1 for dysregulation of host cells." Seminars in Virology. 7. 349-360 (1996)

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  • [Publications] Suzuki,T.: "HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16^<INK4A> and counteracts its inhibitory activity towards CDK4." The EMBO J.15. 1607-1614 (1996)

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  • [Publications] Baffa,R.: "Loss of heterozygosity for chromosome II in adenocarcinoma of the stomach." Cancer Research. 56. 268-272 (1996)

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  • [Publications] Ochiai,A.: "p53 mutations in the non-neoplastic mucosa of the human stomach showing intestinal metaplasia." Int.J.Cancer. 69. 28-33 (1996)

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  • [Publications] Taylor,C.: "Inhibition of Protein phosphatase 2A by cyclic peptides modelled on the microcystin ring." BioMed.Chem.Lett.6. 2113-2116 (1996)

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  • [Publications] Quinn,R.J.: "Inhibition of Protein phosphatase 2A by cantharidin analogues." BioMed.Chem.Lett.(in press). (1997)

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  • [Publications] Priharutono,J.: "Breast cancer case control study : conceptual framework and epidemiological study design." Medical Journal of Indonesia. 4. 143-147 (1995)

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  • [Publications] Suzuki,S.: "Epidemiologic risk factors for breast cancer related to menopausal status in Indonesia." Medical Journal of Indonesia. 4. 169-176 (1995)

    • Description
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  • [Publications] Wakai,K.: "A case-control study of breast cancer among Japanese women in Tokyo" Medical Journal of Indonesia. 4. 177-182 (1995)

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  • [Publications] 徳井 教孝: "萎縮性胃炎とHelicobacter pylori感染の血清疫学研究" 産業医科大学雑誌. 18. 133-140 (1996)

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  • [Publications] 西阪 眞一: "地域住民における健康度自己評価とその後の死亡 -7年間の追跡研究-" 作業医科大学雑誌. 18. (1996)

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  • [Publications] Utoguchi,K.: "Association between self-reported stressful feeling by SACL and mortality in a Japanese community-cohort study." J.Epidemiol.(in press). 119-131 (1997)

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  • [Publications] Tajima,K.: "Research activities of epidemiology in Japan : Infectious disease,epidemiology of AIDS/HIV in Japan." J.Epidemiol.6. S67-S74 (1996)

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  • [Publications] Tajima,K.: "Ethnoepidemiology,a new paradigm,for studying cancer risk factors and prevention strategy." Gann Monograph on Cancer Research. 44. 3-12 (1996)

    • Description
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  • [Publications] Tajima,K.: "HTLV-I/II related disease with special reference to its distribution among Mongoloids." Gann Monograph on Cancer Research. 44. 123-135 (1996)

    • Description
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  • [Publications] Shimizu,H.: "Decreased serum retinol levels in women with cervical dysplasia." British Journal of Cancer. 73. 1600-1604 (1996)

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  • [Publications] Hu,Y.H.: "Association of body mass index,physical activity and reproductive histories with breast cancer : A case control study in Gifu,Japan." Breast Cancer Research and Treatment. (in press). (1997)

    • Description
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  • [Publications] Nagata,C.: "Choice of response scale for health measurement : Comparison of 4,5,and 7-point scales and visual analog scale." Journal of Epidemiology. 6. 192-1297 (1996)

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  • [Publications] Kuroishi,T.: "Gann Monograph on Cancer Research No.41 : Cancer Mortality and Morbidity Statistics" Japan Scientific Societies Press,Tokyo,(1994)

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  • [Publications] Tominaga,S.: "Cancer Surveys Vol.19/20 : Trends in Cancer Incidence and Mortality" Cold Spring Harbor Laboratory Press, 583 (1994)

    • Description
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  • [Publications] Tominaga,S.: "Can they be controlled? In Proceedings of the International Cancer Congress. Plenary and Special Lectures" Monduzzi Editore,Bologna, (1994)

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  • [Publications] Ohno,Y.: "Fundamental Approaches to the Diagnosis and Treatment for Prostate Cancer and BPH" Adenine Press, (1994)

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  • [Publications] Tajima,K.: "Adult T-cell leukemia" Oxford Univ.Press, 230 (1994)

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  • [Publications] Fujiki,H.: "Toxic Microcystits" CRC Press, 203-212 (1996)

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  • [Publications] Kawabuch, B.: "Subcutaneous sarcomas of probable neuronal origin in a transgenic mouse n strain conaining an albumin promoter-fused simian virus 40 large T angige gene." Jpn.J.Cancer Res.85. 601-609 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamamoto, N.: "Carcinogen daily dose-dependence of the viological features and development rate of hepatocellular carcinomas induced by 3'-methyl-4- dimethylaminoazabenzene in the rat." Cancer Letters. 83. 59-68 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyasaka, K.: "Frequent loss of heterozygosity on chromosome 4 in diethyl-nitrosamine- induced C3H/HSM mouse hepatocellular carcinomas in culture" Molecular Carcinogenesis. 13. 37-43 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikuta, T.: "Cholesterol sulfate, a novel activator for the eta isoform of protein kinase C." Cell Growth & Differentiation. 5. 943-947 (1994)

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  • [Publications] Kuroki, T.: "Evaluation of carcinogenic risks to humans : A list of the IARC." Jpn.j.Cancer Res.85. 1320-1321 (1994)

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  • [Publications] Umemori, H.: "Initial events of myelination involve Fyn tyrosine kinasesignaling." Nature. 367. 572-576 (1994)

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  • [Publications] Umemori, H.: "Initial events of myelination involve Fyn tyrosine kinasesignaling." Nature. 367. 572-576 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujimoto, J.: "brt, a mouse gene encoding a novel recepter-type protein-tyrosine kinase, is preferentially expresed in the brain." Oncogene. 9. 693-698 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, T.: "Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kappaB P65 and c-Rel Proteins bound to the NF-kappaB binding site and activates transcription." Oncogene. 9. 3099-3105 (1994)

    • Description
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  • [Publications] Hirai, H.: "Tax pretein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor kappaB and induces nuclear translocation of transcription factor NF-kappaB proteins for transcriptional activation." Proc.Natl.Acad.Sci.USA. 91. 3584-3588 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furukawa, Y.: "HTLV-1 Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leulemia cells." Blood. 85. 1865-1870 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kihana, T.: "Pregnostic significance of the overexpression of c-erbB-2 protein in adenocarcinoma of the uterine cervix." Cancer. 73. 148-153 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuda, H.: "Allele loss on chromosome 16q24,2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extent of spread." Cancer Res.54. 513-517 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuda, H.: "Association among p53 gene mutation, nuclear accumulation of the p53 protein and aggressive phenotypes in breast cancer." Int.J.Cancer. 57. 498-503 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujiki, H.: "Tumor necrosis factor-alpha, a new tumor promoter, enegendered by biochemical studies of okadaic acid." J.Biochem.115. 1-5 (1994)

    • Description
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  • [Publications] Fujiki, H.: "A new tumor promotion pathway and its inhibitors." Cancer Detection and prevention. 18. 1-7 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohta, T.: "Nobdlarin, a potent inhibitor of protein phosphatases 1 and 2A,is a new environmental carcinogen in male F344 rat liver." Cancer Res.54. 6402-6406 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamakoshi, A.: "Serum cholesterol and cancer mortality in Japanese civil service workers : Findings from a nested case-control study." J.Epidemiol.3. 99-107 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wakai, K.: "Risk factors for breast cancer among Japanese women in Tokyo : A case-control study." J.Epidemiol.4. 65-71 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Washio, M.: "Hepatitis B surface antigen and antibody among chronic hemoodialysis patients in Fukuoka, Japan : A high risk for becoming hepatitis B virus carriers." J.Epidemiol.4. 99-102 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Zaninovic, V.: "Geographic independent of HTLV-I and HTLV-II foce in the Andes high land and the Carivean coast of Colombia." AIDS Res Human Reroviruses. 10. 97-101 (1994)

    • Description
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  • [Publications] Tominaga, S.: "Epidemiology of breast cancer in Japan." Cancer Letter. 90. 75-79 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyasaka, K.: "Frequent loss of heterozygosity on chromosome 4 in diethyl-nitrosamine-induced C3H/HSM mouse hepatocellular carcinomas." Molecular Carcinogenesis. 13. 37-43 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, T.: "Identification of an enhancer responsible for tumor marker gene expression by means of transgenic rats." Cancer Res.55. 2651-2655 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Prince Masahito: "Frequent development of pncreatic carcinomas in the Rana nigromaculata group." Cancer Res.55. 3781-3784 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Chida, K.: "Cholesterol sulfate, a second messenger for the eta isoform of protein kinase C,inhibits promotional phase in mouse skin carcinogenesis." Cancer Res.55. 4865-4869 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koike M.: "Growth enhancement of normal human keratinocytes by the antisense oligonucleotide of retinoblatoma susceptibility gene." Oncogene. 10. 117-122 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, T.: "Tax protein of HTLV-1 destabilizes the complex of NF-kappaB and I kappaB-alpha and induces nuclear translocation NF-kappaB for transcriptional activation." Oncogene. 10. 1199-1207 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furukawa, Y.: "HTLV-1 Tax expressed at the same level in infected cells of HAM/TSP patients as in asymptomatic carriers but at a lower level in ATL patients." Blood. 85. 1865-1870 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanai, Y.: "c-erbB-2 gene product directly associates with B-catenin and plakoglobin." Biochem.Biophys.Res.Commun.208. 1067-1072 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimoyama, Y.: "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells." Cancer Res.55. 2206-2211 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshimura, K.: "Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas." Proc.Natl.Acad.Sci.USA. 92. 7416-7419 (1995)

    • Description
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  • [Publications] Sueoka, E.: "Activation of protein kinase C by mycobacterial cord necrosis factor-alpha release in mouse lung tissues." Jpn.J.Cancer Res.86. 749-755 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suganuma, M.: "Tautomycin : an inhibitor of protein phosphatases 1 and 2A but not a tumor promoter on mouse skin and in rat glandular stomach." J.Cancer Res.Clin.Oncol.121. 621-627 (1995)

    • Description
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  • [Publications] Ohno, Y.: "Initiation of international collaborative study on breast cancer between Japan and Indonesia." Medical Journal of Indonesia. 4. 131-134 (1995)

    • Description
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  • [Publications] Budiningsih, S.: "Epidemiological analysis of risk factors for breast cancer in Indonesian females." Medical Journal of Indonesia. 4. 163-168 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohno Y.: "Tea consumption and lung cancer risk : A case-control study in Okinawa, Japan." Jpn.J.Cancer Res.86. 1027-1034 (1995)

    • Description
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  • [Publications] Saku, M: "Mortality in psychiatric patients, with a specific focus on cancer mortality associated with schizophrenia." International Journal of Epidemiology. 24. 366-372 (1995)

    • Description
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  • [Publications] Ogura, C.: "Prevalence of senile dementia in Okinawa, Japan." International Journal of Epidemiology. 24. 373-380 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takezaki, T.: "Incidence of human T lymphotoropic virus type I seroconversion after 40 among Japanese residents in an area where the virus is endemic." The Journal of Infectious Diseases. 171. 559-565 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue, M.: "Protective factor against progression from atorophic gastritis to gastric cancer-data from a cohort study in Japan." Int.J.Cancer. 66. 309-314 (1996)

    • Description
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  • [Publications] Inoue, M.: "Epidemiological features of first-visit outpatients in Japan : comparison with general population and variation by sex, age, and season." J.Clin.Epidemiol.50. 69-77 (1997)

    • Description
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  • [Publications] Koo, L,C.: "Dietary and lifestyle correlates of passive smoking in Hong kong, Japan, Sweden, and USA." Social Science and Medicine. (in press). (1997)

    • Description
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  • [Publications] Tsunashima, K.: "A novel clonality assay for the mouse : appliciation to hepatocellular carcinomas induced with diethylnitrosamine." Molecular carcinogenesis. 15. 33-37 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koyama, Y.: "Lectin affinity electrophoretic demonstration of tissue specificity and malignant alteration of human alpha-fetoprotein isoforms produced in transgenic mice." Biocemical and Biophysical Research Communications. 223. 757-761 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishida, T.: "Intra-articular calcifying synovial sarcoma mimicking synovial chondromatosis." Skeletal Radiol.25. 766-769 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuroki, T.: "Report on the 5th Japanese-German workshop on molecular and cellular aspects of carcinogenesis." Intl.J.Cancer. 66. 1-5 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koike, M.: "DMSO induces apoptosis in SV40-transformed hu-man keratinocytes, but not in normal keratino-cytes." Cancer Letters. 108. 185-193 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Jia, L.-G.: "Screening the p53 status of human cell lines using a yeast functional assay." Mol.Carcinog.(in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murakami, A.: "Absence of down-regulation and translocation of the eta isoform of protein kinase C in normal human keratinocytes." J.Invest, Dermatol.106. 790-794 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fijimoto, J.: "Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with (2 ; 5)." Proc.Natl.Acad.Sci.USA. 93. 4181-4186 (1996)

    • Description
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  • [Publications] Iwahara, T.: "Molecular characterization of ALK,a receptor tyrosine kinase expressed specifically in the the nervous system." Oncogene. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tezuka, T.: "Physical and functional association of the Cb1 proto-oncogene product with a Scr-family protein tyrosine kinase, p53/561yn, in the B cell antigen receptor-mediated signaling." J.Exp.Med.183. 675-680 (1996)

    • Description
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  • [Publications] Yoshida, M.: "Multiple targets of HTLV-1 for dysregulation of host cells." Seminars in Virology. 7. 349-360 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, T.: "HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16^<1NK4A> and counteracts its inhibitory activity towards CDK4." The EMBO J.15. 1607-1614 (1996)

    • Description
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  • [Publications] Baffa, R.: "Loss of heterozygosity for chromosome 11 in adenocarcinoma of the stomach." Cancer Research. 56. 268-272 (1996)

    • Description
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  • [Publications] Ochiai, A.: "p53 mutations in the non-neoplastic mucosa of the human stomach showing intestinal metaplasia." Int.J.Cancer. 69. 28-33 (1996)

    • Description
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  • [Publications] Teylor, C.: "Inhibition of protein phosphatase 2A by cyclic peptides modelled on the microcystin ring." BioMed.Chem.Lett.6. 2113-2116 (1996)

    • Description
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  • [Publications] Quinn, R.J.: "Inhibition of protein phosphatase 2A by cantharidin analogues." BioMed.Chem.Lett.(in press). (1997)

    • Description
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  • [Publications] Priharutono, J.: "Breast cancer case control study ; conceptual framework and epidemiological study design." Medical Journal of Indonesia. 4. 143-147 (1995)

    • Description
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  • [Publications] Suzuki, S.: "Epidemiologic risk factors for breast cancer related to menopausal status in Indonesia." Medical Journal Indonesia. 4. 169-176 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wakai, K.: "A case-control study of breast cancer among Japanese women in Tokyo." Medical Journal of Indonesia. 4. 177-182 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Utoguchi, K.: "Association between self-reported stressful feeling by SACL and mortality in a Japanese community-cohort study." J.Epidemiol.(in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tajima, K: "Research activities of epidemiology in Japan : Infectious disease, epidemiology of AIDS/HIV in Japan." J.Epidemiol.6. S67-S74 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tajima, K.: "Ethnoepidemiology, a new paradigm, for studying cancer risk factors and prevention strategy." Gann Monograph on Cancer Research. 44. 3-12 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tajima, K.: "HTLV-I/II related disease with special reference to its distribution among Mongoloids." Gann Monograph on Cancer Research. 44. 123-135 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimizu, H.: "Decreased serum retinol levels in women with cervical dysplasia." British Journal of Cancer. 73. 1600-1604 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hu, Y.H.: "Association of body mass index, physical activity and reproductive histories with breast cancer : A case control study in Gifu, Japan." Breast Cancer Research and Treatment. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagata, C.: "Choice of response scale for health measurement : Comparison of 4,5. and 7-point scales and visual analog scale." Journal of Epidemiology. 6. 192-197 (1996)

    • Description
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  • [Publications] Kuroishi, T.et al.: Japan Scientific Societies Press, Tokyo. Gann Monograph on Cancer Research No.41 : Cancer Mortality and Morbidity Statistics, (1994)

    • Description
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  • [Publications] Tominaga, S.et al.: Cold Spring Harbor Laboratory Press. Cancer Surveys Vol.19/20 : Trends in Cancer Incidence and Mortality, (1994)

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  • [Publications] Tominaga, S.et al.: Monduzzi Editore, Bologna. Can they be controlled? In Proceedings of the International Cancer Congress. Plenary and Special Lectures, (1994)

    • Description
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  • [Publications] Ohno, Y.et al.: Adenine Press. Fundamental Approaches to the Diagnosis and Treatment for Prostate Cancer and BPH, (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tajima, K.et al.: Oxford Univ.Press. Adult T-cell leukemia, (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujiki, K.: CRC Press. Toxic Microcystis, 203-232 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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