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1996 Fiscal Year Final Research Report Summary

Treatment of Acute Rcspiratory Infections is Thailand

Research Project

Project/Area Number 06045041
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionUniversity-to-University Cooperative Research
Research InstitutionNagasaki University

Principal Investigator

NAGATAKE Tsuyoshi  Institute of Tropical Medicine, Nagasaki University, Professor, 熱帯医学研究所, 教授 (30164445)

Co-Investigator(Kenkyū-buntansha) プラシット タラビチクル  チェンマイ大学, 付属病院・中央検査部, 助教授
THIRA Sirisanthana  Department of Medicine, Chiang Mai University, 医学部, 学部長
MASAKI Hironori  Institute of Tropical Medicine, Nagasaki University, 熱帯医学研究所, 助手 (40244058)
KOBAYASHI Shinobu  Department of Medicine, Nagasaki University, 医学部・付属病院, 助手 (10274656)
AKIYAMA Moritoshi  Department of Medicine, Nagasaki University, 医学部・付属病院, 助手 (50244067)
WATANABE Kiwao  Institute of Tropical Medicine, Nagasaki University, 熱帯医学研究所, 助手 (20220874)
OISHI Kazunori  Department of Medicine, Nagasaki University, 医学部・付属病院, 講師 (80160414)
RIKITOMI Naoto  Institute of Tropical Medicine, Nagasaki University, 熱帯医学研究所, 助教授 (70175032)
PRASIT Tharavichitkul  Department of Microbiology, Chiag Mai University
Project Period (FY) 1994 – 1996
KeywordsThailand / HIV / Acute Respiratory Infections / MIC / Ciprofloxacin / community aquired pneumonia / 併用療法
Research Abstract

Treatment of Acute Respiratory Infections in Thailand
We have had the collaboration study about acute respiratory infections with Chiang Mai University since 1989. In this time, we had a study about "Treatment of Acute Respiratory Infections in Thailand" during three years from April, 1994 to March, 1997.
In the first year, we ahd a study to determine causative organisms of acute respiratory infections, estimate current chemotherapy and examine resistance of organisms to antibiotics in Method General Hospital. The major pathogens were H.influenzae and S.pneumoniae, 70% of all causative organisms. The others were M.catarrhalis and K.pneumoniae. 80% of patients were treated by PenicillineG.It was interesting to find tetracyclline resistant H.influenzae, penicilline resistant S.pneumoniae and penicilline resistant M.catarrhalis
In the second year, we studied 32 patients community aquired pneumonia who were admitted in Nakorn Ping Hospital of Chiang Mai. The sex distribution form the total nu … More mber of patients were 27 for male and 5 for female. The mean age were 37.9 years of male and 50.6 years for female. HIV antibody was resistered in 25 of the 27 males and 4 of the 5 females. This was positive in 17 (68%) of males and 2 (50%) of females patients. Sputum culture was performed in 31 patients with isolation of causative organisms in 21 cases. We found K.pneumoniae (7 cases), H.influenzae (4 cases), P.aeruginosa (3 cases) as causative organisms. We examined MIC of various antibiotics to causative organisms. MIC of Ciprofloxacin was 0.006mug/dl to H.influenzae, 0.025mug/dl to K.pneumoniae. In the third year, we compared with effect of chemotherapy between Gentamycin and Ciprofloxacin. 19 patients with community acquired pneumonia were enrolled in Nakorn Ping Hosputal. Major pathogens of comunity acquired pneumonia were S.pneumoniae, S aureus, H influenzae and P.aeruginosa.100% (8/8) or the petients given PenicilineG puls Ciprofloxacin, 50% (1/2) of patients given PenicillineG puls Gentamicin were effective in community acquired pneumonia. After having more cases, we will recommend the therapy by PenicillineG puls Ciprofloxacin to WHO and Thailand. Less

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Published: 1999-03-09  

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