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1996 Fiscal Year Final Research Report Summary

Role of magnesium on prevention of geriatric disases.

Research Project

Project/Area Number 06304028
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section総合
Research Field Hygiene
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

ITOKAWA Yoshinori  KYOTO UNIVERSITY Graduate School of Medicine, Professor, 医学研究科, 教授 (80025593)

Co-Investigator(Kenkyū-buntansha) KIMURA Mieko  KYOTO UNIVERSITY Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 (60025658)
KOBAYASHI Akio  Schowa University School of Medicine, Professor, 医学部, 教授 (30153589)
MORII Hirotoshi  Osaka City University Medical School, Professor, 医学部, 教授 (40046983)
GOTO Shiro  Tokyo University of Agriculture, Professor, 農学部, 教授 (60078079)
NISHIMUTA Mamoru  KYOTO UNIVERSITY National Institute of Health and Nutrition, Chief, 栄養研究所, 室長 (50112850)
Project Period (FY) 1994 – 1996
Keywordsminimum requirement of magnesium / excess intake of phosphorus / parathyroid / diabeters mellitus / ischemic heart disease / essential hypertension / chronic diseases in childhood / osteoporosis
Research Abstract

Aim of this cooperative study is clarify the physiological and pharmacological function of magnesium in relation to prevent or cure the geriatric diseases. The minimum dietary requirement for adults was found to be 80mg/1000Kcal by balance study, but this value influenced by various conditions, i.e.amounts of other nutrients intake, strength of stress, quantity of exercise, e.t.c., . Another study to clarify the dietary allowance of magnesium was undertaken in long-term hospitalized patients aged 70-90 years and healthy young adults aged 19-40 years. The magnesium status were assessed by plasma levels and the dietary intake of magnesium. Significant correlation was observed between dietary intake and plasma levels of magnesium and it wa found that plasma magnesium was decreased below the normal range in some subjects when daily intake of magnesium was below 150mg. Therefore, we assumed that the minimum requirement of magnesium for japanese adults including aged peoples were 150mg/day. … More The dietary allowance should be set around 300mg/day by adding safety coefficients. In animal experiments, the increasing level of phosphorus in rats resulted in calcification of kidneys and decrease in renal function. But addition of magnesium to these rates prevented the occurance of these abnormalities. Thyoparathyroidectomy in ruminants decreased serum magnesium and free hydroxyproline, an index of bone resorption. These results suggest that magnesium metabolism in ruminants is controlled by calcium regulating hormones. In clinical studies, patients with diabetes, ischemic heart disease and essential hypertension showed low serum magnesium levels. especially, magnesium levels were very low in diabetic patients with poor control of blood sugar. By oral administration of hypoglycemic agents increased serum magnesium level through the improvement of blood sugar control. Children suffered from obesity, hypertension and diabetes mellitus decreased whole blood ionized magnesium. It was important to maintain the nomral magnesium status for prevention of chronic diseases in childhood. By the review article on relationship between magnesium and bone metabolsim, it was suggested that magnesium deficiency may exist in osteoporosis and magnesium deficiency could be a risk factor in the pathogenesis of osteoporosis. Less

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 糸川嘉則: "微量元素" 医学のあゆみ. 169. 934-938 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 糸川嘉則: "マグネシウム、その他の微量元素" 臨床栄養. 85. 179-182 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 西牟田守: "人体におけるマグネシウム代謝の研究、国立健康・栄養研究所での研究の総括" マグネシウム. 16(Suppl). 5-11 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 五島孜郎: "The action of magnesium in reducing renal calcification in rats receiving high phosphorus supplemented diet." Nutrition Research. 15. 1673-1681 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 斉藤昇: "成人病におけるマグネシウム代謝と病因との関係" マグネシウム. 16(Suppl). 131-141 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林昭夫: "小児マグネシウム代謝における最近の動向" マグネシウム. 16(Suppl). 81-91 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 糸川嘉則: "生体内金属元素" 光生館, 228 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 糸川嘉則: "マグネシウム-成人病との関係-" 光生館, 271 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshinori ITOKAWA: "Trace metals." Igaku no Ayumi. 169-9. 934-938 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshinori ITOKAWA: "Magnesium and other trace elements. Dietary allowance for Japanese." Clinical Nutrition. 85-2. 179-182 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mamoru NISHIMUTA: "Studies on human magnesium metabolism. -Summary of the National Institute of Health and Nutrition-" J.Jap.Soc.Mg Res. 16-Suppl. 5-11 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shiro GOTO: "The action of magnesium in reducing renal calcification in rats receiving high phosphorus supplemented diet." Nutrition Res.15. 1673-1681 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noboru SAITO: "The relationship between magnesium metabolism and pathogenic factors in adult diseases." J.Jap.Soc.Mg Res. 16-Suppl. 131-141 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akio KOBAYASHI: "The recent research of magnesium metabolism in children." J.Jap.Soc.Mg Res. 16-Suppl. 81-91 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshinori ITOKAWA: Metallic elements in living body.Koseikan Co., Japan, 228 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshinori ITOKAWA: Magnesium, in relation to diseases in aged.Koseikan Co., Japan, 271 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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