1996 Fiscal Year Annual Research Report

感情障害の病因に関する神経・免疫・内分泌学的研究

Research Project

Project/Area Number	06304033
Research Institution	HIROSHIMA UNIVERSITY
Principal Investigator	山脇成人広島大学, 医学部, 教授 (40230601)
Co-Investigator(Kenkyū-buntansha)	樋口輝彦昭和大学, 医学部, 教授 (90105883) 斎藤利和札幌医科大学, 保健医療学部, 教授 (50128518) 小山司北海道大学, 医学部, 教授 (10113557) 神庭重信山梨医科大学, 教授 (50195187) 加藤進昌滋賀医科大学, 教授 (10106213)
Keywords	感情障害 / 免疫 / 内分泌 / 抗うつ薬 / ストレス / セロトニン
Research Abstract	本研究により、以下の事柄が明らかになった。 1.感情障害において皮質血流の低下していることがXe-CTを用いた検討により示唆された。 2.抗うつ薬の作用機序として、前頭葉皮質ではドーパミン再取り込みがドーパミン・トランスポーターのみならずノルアドレナリン・トランスポーターも介している可能性が示唆された。 3.学習性無カラットの成立にNMDA受容体が重要な役割を担っていることが明らかになった。 4.有機錫投与により、視床下部-下垂体-副腎皮質機能の変化とともに行動も変化し、うつ病の病態モデルと成り得ることを示した。 5.胎生期ストレスにより内分泌反応の変化を示すことが示唆された。 6.拘束ストレスによるモノアミン遊離の亢進にインターロイキン-1が関与していることを明らかにした。 7.がん患者におけるうつ状態の発現について調査し、20〜40%がうつ状態を呈しうることを明らかにした。 8.新規抗うつ薬がG蛋白-cAMP生成能を亢進する所見が得られた。 9.初代培養神経細胞において抗うつ薬が総じて細胞内カルシウム情報伝達に抑制的に働くことを明らかにした。 10.細胞内微小管関連蛋白質のりん酸化・脱りん酸化を抗うつ薬が修飾することを明らかにした。以上のように神経・免疫・内分泌学的相互作用から感情障害の病態について検討した。

Research Products

(81 results)

All Other

All Publications (81 results)

[Publications] Shintani, F.: "Bioactive 6-nitronoreponephrine identified in mammalian brain." J. Biol. Chem.271. 13561-13565 (1996)
[Publications] Manki, H.: "Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders." J. Affect. Dis.40. 7-13 (1996)
[Publications] Suzuki, E.: "Introduciton of interleukin-1β and interleukin-1 receptor antagonist mRNA by chronic treatment with various psychotropics in widespread area of the rat brain." Neurosci. Lett.215. 201-204 (1996)
[Publications] Tsuchiya, K.: "Effect of repeated methamphetamine pretreatment on freezing behavior induced by conditioned fear stress." Pharmacol. Biochem. Behav.54. 687-691 (1996)
[Publications] Inoue, T.: "Bromocriptine treatment of tricyclic and heterocyclic antidepressant-resistant depression." Biol. Psychiatry. 40. 151-154 (1996)
[Publications] Hashimoto, S.: "Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats." Psychopharmacol.123. 182-186 (1996)
[Publications] Odagaki., Y.: "Functional coupling between metabotropic glutamate receptors and G proteins in rat brain membranes." Eur. J. Pharmacol.300. 151-154 (1996)
[Publications] Inoue, T.: "Effect of citalopram a selective serotonin reuptake inhibitor, on the acquisition of conditioned freezing." Eur. J. Pharmacol.311. 1-6 (1996)
[Publications] Izumi, T.: "Effect of the selective CCK_B receptor antagonist LY288513 on conditioned fear stress in rats." Eur. J. Pharmacol.300. 25-31 (1996)
[Publications] Abekawa T.: "Effect of nitric oxide synthesis inhibition on methamphetemine-induced dopaminergic and serotonergic neurotoxicity in the rat brain." J. Neural Transm.103. 671-680 (1996)
[Publications] Ohmori, T.: "The role of glutamate in behavioral and neurotoxic effects of methamphetamine." Neurochem. Int.29. 301-307 (1996)
[Publications] Tsuchiya, K.: "Effects of footshock stress on regional brain monoamine metabolism and the acquisition of conditioned freezing in rats previously exposed to repeated methamphetamine." Prog. Neuro-Psychopharmacol. Biol. Psychiat.20. 1239-1250 (1996)
[Publications] Ohmori, T.: "The role of glutamate in the neurotoxic effects of methamphetamine." Ann. New York Acad. Sci.801. 316-326 (1996)
[Publications] 井上猛: "抗うつ薬に治療抵抗性のうつ病の実態とその治療戦略" 精神神経誌. 98. 329-342 (1996)
[Publications] 泉剛: "ドーパミン受容体作動薬pergolideが有効であった治療抵抗性うつ病の1例" 精神医学. 38. 868-870 (1996)
[Publications] 三浦淳: "難治性のうつ病に対するブロモクリプチンの治療効果" 精神医学. 38. 399-404 (1996)
[Publications] 土屋潔: "Conditioned fear stress負荷時の脳内ドーパミン代謝に及ぼすメトアンフェタミン反復投与の影響" 神経精神薬理. 18. 655-657 (1996)
[Publications] 三国雅彦: "生育環境ストレスによる神経系の発達に伴う可塑的変化" 脳と精神の医学. 7. 1-10 (1996)
[Publications] 三国雅彦: "精神疾患とドーパミン並びにセロトニン受容体亜型" 臨床精神医学. 25. 389-395 (1996)
[Publications] 三国雅彦: "躁うつ病の薬理・生化学:セロトニン系" Clinical Neuroscience. 14. 400-403 (1996)
[Publications] 三国雅彦: "気分障害と受容体-細胞内情報伝達系機能異常" 臨床精神医学. 25. 1293-1301 (1996)
[Publications] Nagaki. S: "The role of vasopressin, somatostatin and GABA in febrile convulsion in rat pups." Life Sci.58. 2233-2242 (1996)
[Publications] Takazawa, A.: "Potent and long-lasting anticonvulsant effects of 1-naphthylacetyl spermine, an analogue of Joro spider toxin, against amygdaloid kindled seizures in rats." Brain Res.706. 173-176 (1996)
[Publications] Ikeda, M.: "Nitric oxide-synthase-containing neurons in the hippocampus are preserved in trimethyltin intoxication." Brain Res.712. 168-170 (1996)
[Publications] Toki, S.: "Changes in GABA_A receptor function and cross tolerance to ethanol in diazepam-dependent rats." Alcoholism : Cljn. Exp. Res.20. 40A-44A (1996)
[Publications] Ashizawa, T.: "Effect of ceruletide on abnormal perioral movements and the dopamine receptor-adenylate cyclase system in rats chronically treated with fluphenazine." Psychopharmacol.125. 185-194 (1996)
[Publications] Yamamoto, M.: "Reduced immunoreactivity of adenylyl cyclases in dementia of the Alzheimer type." NeuroReport. 7. 2965-2970 (1996)
[Publications] Toki, S.: "Diazepam physical dependence and withdrawal in rat is associated with alteration in GABA_A receptor function." Life Sci.59. 1631-1641 (1996)
[Publications] 樋口輝彦: "セロトニン" ホルモンと臨床. 44. 497-505 (1996)
[Publications] 大嶋明彦: "抗うつ薬の進歩" 作業療法ジャーナル. 30. 302-304 (1996)
[Publications] 樋口輝彦: "総うつ病の薬理・生化学・抗うつ薬の薬理とうつ病の生物学的仮説" Clinical Neuroscience. 14. 391-394 (1996)
[Publications] 広瀬徹也: "各種領域におけるうつ病" 最新精神医学. 1. 116-130 (1996)
[Publications] 大嶋明彦: "老年期うつ状態の治療の諸相Augmentation therapy" 老年精神医学雑誌. 7. 1102-1108 (1996)
[Publications] Yamawaki、 S.: "Role of intracellular calcium mechanisms in the pathophysiology of affective disroders." Preclinical and Clinical Strategies for the Treatment of Neurodegenerativem, Cerebrovascular and Mental Disorders.11. 106-115 (1996)
[Publications] Yamawaki, S.: "Enhanced calcium response to serotonin in platelets from patients with affective disorders." J. Psychiat. Neurosci.21. 321-324 (1996)
[Publications] Shimizu, M.: "Effects of chronic exposure to desipramine and mianserin on Ca^<2+> mobilization induced by noradrenaline, acetylcholine, and high K in rat frontcortical neurons." Neuropsychobiol.33. 66-70 (1996)
[Publications] Takebayashi, M.: "γ-Amonobutyrkc acid increases intracellular Ca^<2+> concentration in cultured cortical neurons : Role of Cl transport." Eur. J. Pharmacol.297. 137-143 (1996)
[Publications] Okamoto, Y.: "Addition of lithium to chronic antidepressant treatment potentiates presynaptic serotonergic function without changes in serotonergic receptors." Neuropsychobiol.33. 17-20 (1996)
[Publications] Kagaya, A.: "TJS-010, a new prescription of oriental medicine, enhances 8-OH-DPAT-induced effect in rats." J. Neural Transm.103. 69-75 (1996)
[Publications] Kagaya, A.: "Effect of citalopram on the desensitization of serotonin-2A receptor-mediated calcium mobilization in rat glioma cells." Prog. Neuro-Psychopharmacol. Biol. Psychiat.20. 157-166 (1996)
[Publications] Akechi, T.: "Usage of haloperidol for delirium in cancer patients." Support Care Cancer. 4. 390-392 (1996)
[Publications] Yamaji, T.: "Effect of clomipramine and verapamil on 5-HT-induced intracellular calcium changes in individual C6 glioma cells." Neuropsychobiol.33. 55-59 (1996)
[Publications] Minagawa, H.: "Psychiatric morbidity in terminally ill cancer patients." Cancer. 78. 1131-1137 (1996)
[Publications] Shimizu, M.: "Chronic amitriptyline exposure reduces 5-HT, receptor-mediated cyclic GMP formation in NG108-15 cells." Brain Res.741. 89-94 (1996)
[Publications] Kagaya, A.: "Differential regulation of intracellular signaling systems by sodium fluoride in rat glioma cells." J. Neurochem.66. 1483-1488 (1996)
[Publications] Fujikawa, T.: "Response of patients with major depression and silent cerebral infarction to antidepressant drug therapy, with emphasis on central nervous system adverse reactions." Stroke. 27. 2040-2042 (1996)
[Publications] Yamaji, T.: "Effects of carbamazepine and sodium valproate on 5-HT-induced calcium increase in individual C6 rat glioma cells." Neuropsychobiol.34. 22-25 (1996)
[Publications] Kugaya, A.: "Effect of interferon-α on DOI-induced wer-dog shakes in rats." J. Neural Transm.103. 947-955 (1996)
[Publications] 山脇成人: "サイコオンコロジー" 臨床腫瘍学. 1333-1363 (1996)
[Publications] 藤川徳美: "無症候性脳梗塞とうつ状態" Therapeutic Research. 17. 3061-3062 (1996)
[Publications] 加賀谷有行: "セロトニン2A受容体〜細胞内情報伝達系と感情障害" 脳と精神の医学. 7. 255-260 (1996)
[Publications] 岡本泰昌: "がん患者に関する精神医学的リエゾンカンファレンスの試み" 臨床精神医学. 25. 1443-1448 (1996)
[Publications] 加賀谷有行: "精神障害とCa^<2+>" Clinical Neuroscience. 14. 217-219 (1996)
[Publications] 岡本泰昌: "抗うつ薬抵抗性うつ病に対するリチウム追加投与の影響" 精神医学. 38. 405-409 (1996)
[Publications] 山脇成人: "免疫と脳のクロストーク-がん領域におけるPsychoimmunology-" 癌治療と宿主. 8. 31-38 (1996)
[Publications] 大久保善朗: "EICD-10による外来初診患者統計" 精神医学. 36. 505-509 (1996)
[Publications] Kaneko, K.: "The effects of single and repeated phencyclidine administration of ^<128>I-iomazenil binding in the rat brain." Neurochem. Int.54. 687-691 (1996)
[Publications] Arinami, T.: "Further association sdudy on dopamine D2 receptor variant S311C om schizophrenia and affective disorders." Am. J. Med. Gen. (Neuropsychiat. Gen.). 67. 133-138 (1996)
[Publications] 渋谷治男: "うつ病の神経科学" 最新の伝達物質-受容体の分子機構と関連神経疾患. 204-216 (1996)
[Publications] Kagaya, A.: "Plasma levels of cyclic GMP, immune parameters and depressive status during interferon therapy : A prospective study in Japan." Neuropsychobiol.(in press). (1997)
[Publications] Yamaji, T.: "Chronic treatment with antidepressants, verapamil or lithium inhibits the serotonin-induced intracellular calcium response in individual C6 rat glioma cells." Life Sci.(in press). (1997)
[Publications] Suzuki, E.: "Immobilization stress increases mRNA levels of interleukin-1 receptor antagonist in various rat brain." NeuroReport. (in press). (1997)
[Publications] Tokunaga, M.: "Alteration of benzodiazepine receptor binding potential in anxiety and somatoform disorders." Radiation Res. Assoc.(in press). (1997)
[Publications] 三国雅彦: "感情障害の受容体-細胞内情報伝達系機脳障害" 脳シクナルカスケードと精神疾患. (in press). (1997)
[Publications] 三国雅彦: "セロトニン受容体機能とうつ病" 感情障害-基礎と臨床-. (印刷中). (1997)
[Publications] Kato, N.: "Expression of c-fos mRNA after audiogenic seizure in adult rats with neonatal hypothyroidism." Mol. Brain Res.(in press). (1997)
[Publications] Ishida, N.: "Trimethyltin syndrome as a hippocampal degeneration model : temporal changes and neurochemical features of seizure susceptibility and learning impairment." Neurosci. (in press). (1997)
[Publications] Akaike, M.: "Abnormal behavior, spatial learning impairment and neuropeptides caused by temporary neonatal hypothyroidism." Thyroid and Brain. (in press). (1997)
[Publications] 網島浩一: "中枢神経系のソマトスタチン" 神経精神薬理. (印刷中). (1997)
[Publications] 網島浩一: "精神疾患における情動異常" 情動とホルモン. (印刷中). (1997)
[Publications] 加藤進昌: "基礎研究-神経ペプチド" 感情障害-基礎と臨床-. (印刷中). (1997)
[Publications] 石田展弥: "天然毒による中枢神経障害の基礎-その向精神作用と作用機序-" 神経精神薬理. (印刷中). (1997)
[Publications] 斎藤利和: "感情障害と細胞内情報伝達機構" 神経精神薬理. (印刷中). (1997)
[Publications] Kamata, H.: "Alterations of tubulin function caused by chronic antidepressant treatment in rat brain" Cell. Mol. Neurobiol.(in press). (1997)
[Publications] Ozawa, H.: "Cyclic AMP production and degeneration systems in postmortem cortex of depressed patients." J. Neural Transm.(in press). (1997)
[Publications] Hashimoto, E.: "Alteration of GTP binding proteins in postmortem brains of heroin addicts." Alcoholism : Clin. Exp. Res.(in press). (1997)
[Publications] Kamata, H.: "Dimeric tubulin stimulated adenylyl cyclase activity after long-trm amitriptyline treatment." Life. Sci.(in press). (1997)
[Publications] Yamamoto, M.: "Ca^<2+>/CaM-sensitive adenylyl cyclase activity is decreased in the Alzheimer's brain : Possible relation to type I adenylyl cyclase." J. Neural Transm.(in press). (1997)
[Publications] Yamawaki, S.: "Intracellular calcium signaling systems in the pathophysiology of affective disorders." Ca Ion Modulators : New Wave of Psychotropic Drugs in Japan. (in press). (1997)
[Publications] Kato, N.: "PThe Hippocampus, Functions and Clinical Relevance" Kato, N., 300 (1996)
[Publications] 山脇成人: "感情障害と神経・免疫・内分泌相関" 山脇成人(印刷中), 140

1996 Fiscal Year Annual Research Report

感情障害の病因に関する神経・免疫・内分泌学的研究

Principal Investigator

山脇 成人 広島大学, 医学部, 教授 (40230601)

Research Products

[Publications] Shintani, F.: "Bioactive 6-nitronoreponephrine identified in mammalian brain." J. Biol. Chem.271. 13561-13565 (1996)

[Publications] Manki, H.: "Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders." J. Affect. Dis.40. 7-13 (1996)

[Publications] Suzuki, E.: "Introduciton of interleukin-1β and interleukin-1 receptor antagonist mRNA by chronic treatment with various psychotropics in widespread area of the rat brain." Neurosci. Lett.215. 201-204 (1996)

[Publications] Tsuchiya, K.: "Effect of repeated methamphetamine pretreatment on freezing behavior induced by conditioned fear stress." Pharmacol. Biochem. Behav.54. 687-691 (1996)

[Publications] Inoue, T.: "Bromocriptine treatment of tricyclic and heterocyclic antidepressant-resistant depression." Biol. Psychiatry. 40. 151-154 (1996)

[Publications] Hashimoto, S.: "Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats." Psychopharmacol.123. 182-186 (1996)

[Publications] Odagaki., Y.: "Functional coupling between metabotropic glutamate receptors and G proteins in rat brain membranes." Eur. J. Pharmacol.300. 151-154 (1996)

[Publications] Inoue, T.: "Effect of citalopram a selective serotonin reuptake inhibitor, on the acquisition of conditioned freezing." Eur. J. Pharmacol.311. 1-6 (1996)

[Publications] Izumi, T.: "Effect of the selective CCK_B receptor antagonist LY288513 on conditioned fear stress in rats." Eur. J. Pharmacol.300. 25-31 (1996)

[Publications] Abekawa T.: "Effect of nitric oxide synthesis inhibition on methamphetemine-induced dopaminergic and serotonergic neurotoxicity in the rat brain." J. Neural Transm.103. 671-680 (1996)

[Publications] Ohmori, T.: "The role of glutamate in behavioral and neurotoxic effects of methamphetamine." Neurochem. Int.29. 301-307 (1996)

[Publications] Tsuchiya, K.: "Effects of footshock stress on regional brain monoamine metabolism and the acquisition of conditioned freezing in rats previously exposed to repeated methamphetamine." Prog. Neuro-Psychopharmacol. Biol. Psychiat.20. 1239-1250 (1996)

[Publications] Ohmori, T.: "The role of glutamate in the neurotoxic effects of methamphetamine." Ann. New York Acad. Sci.801. 316-326 (1996)

[Publications] 井上 猛: "抗うつ薬に治療抵抗性のうつ病の実態とその治療戦略" 精神神経誌. 98. 329-342 (1996)

[Publications] 泉剛: "ドーパミン受容体作動薬pergolideが有効であった治療抵抗性うつ病の1例" 精神医学. 38. 868-870 (1996)

[Publications] 三浦淳: "難治性のうつ病に対するブロモクリプチンの治療効果" 精神医学. 38. 399-404 (1996)

[Publications] 土屋潔: "Conditioned fear stress負荷時の脳内ドーパミン代謝に及ぼすメトアンフェタミン反復投与の影響" 神経精神薬理. 18. 655-657 (1996)

[Publications] 三国雅彦: "生育環境ストレスによる神経系の発達に伴う可塑的変化" 脳と精神の医学. 7. 1-10 (1996)

[Publications] 三国雅彦: "精神疾患とドーパミン並びにセロトニン受容体亜型" 臨床精神医学. 25. 389-395 (1996)

[Publications] 三国雅彦: "躁うつ病の薬理・生化学:セロトニン系" Clinical Neuroscience. 14. 400-403 (1996)

[Publications] 三国雅彦: "気分障害と受容体-細胞内情報伝達系機能異常" 臨床精神医学. 25. 1293-1301 (1996)

[Publications] Nagaki. S: "The role of vasopressin, somatostatin and GABA in febrile convulsion in rat pups." Life Sci.58. 2233-2242 (1996)

[Publications] Takazawa, A.: "Potent and long-lasting anticonvulsant effects of 1-naphthylacetyl spermine, an analogue of Joro spider toxin, against amygdaloid kindled seizures in rats." Brain Res.706. 173-176 (1996)

[Publications] Ikeda, M.: "Nitric oxide-synthase-containing neurons in the hippocampus are preserved in trimethyltin intoxication." Brain Res.712. 168-170 (1996)

[Publications] Toki, S.: "Changes in GABA_A receptor function and cross tolerance to ethanol in diazepam-dependent rats." Alcoholism : Cljn. Exp. Res.20. 40A-44A (1996)

[Publications] Ashizawa, T.: "Effect of ceruletide on abnormal perioral movements and the dopamine receptor-adenylate cyclase system in rats chronically treated with fluphenazine." Psychopharmacol.125. 185-194 (1996)

[Publications] Yamamoto, M.: "Reduced immunoreactivity of adenylyl cyclases in dementia of the Alzheimer type." NeuroReport. 7. 2965-2970 (1996)

[Publications] Toki, S.: "Diazepam physical dependence and withdrawal in rat is associated with alteration in GABA_A receptor function." Life Sci.59. 1631-1641 (1996)

[Publications] 樋口輝彦: "セロトニン" ホルモンと臨床. 44. 497-505 (1996)

[Publications] 大嶋明彦: "抗うつ薬の進歩" 作業療法ジャーナル. 30. 302-304 (1996)

[Publications] 樋口輝彦: "総うつ病の薬理・生化学・抗うつ薬の薬理とうつ病の生物学的仮説" Clinical Neuroscience. 14. 391-394 (1996)

[Publications] 広瀬徹也: "各種領域におけるうつ病" 最新精神医学. 1. 116-130 (1996)

[Publications] 大嶋明彦: "老年期うつ状態の治療の諸相Augmentation therapy" 老年精神医学雑誌. 7. 1102-1108 (1996)

[Publications] Yamawaki、 S.: "Role of intracellular calcium mechanisms in the pathophysiology of affective disroders." Preclinical and Clinical Strategies for the Treatment of Neurodegenerativem, Cerebrovascular and Mental Disorders.11. 106-115 (1996)

[Publications] Yamawaki, S.: "Enhanced calcium response to serotonin in platelets from patients with affective disorders." J. Psychiat. Neurosci.21. 321-324 (1996)

[Publications] Shimizu, M.: "Effects of chronic exposure to desipramine and mianserin on Ca^<2+> mobilization induced by noradrenaline, acetylcholine, and high K in rat frontcortical neurons." Neuropsychobiol.33. 66-70 (1996)

[Publications] Takebayashi, M.: "γ-Amonobutyrkc acid increases intracellular Ca^<2+> concentration in cultured cortical neurons : Role of Cl transport." Eur. J. Pharmacol.297. 137-143 (1996)

[Publications] Okamoto, Y.: "Addition of lithium to chronic antidepressant treatment potentiates presynaptic serotonergic function without changes in serotonergic receptors." Neuropsychobiol.33. 17-20 (1996)

[Publications] Kagaya, A.: "TJS-010, a new prescription of oriental medicine, enhances 8-OH-DPAT-induced effect in rats." J. Neural Transm.103. 69-75 (1996)

[Publications] Kagaya, A.: "Effect of citalopram on the desensitization of serotonin-2A receptor-mediated calcium mobilization in rat glioma cells." Prog. Neuro-Psychopharmacol. Biol. Psychiat.20. 157-166 (1996)

[Publications] Akechi, T.: "Usage of haloperidol for delirium in cancer patients." Support Care Cancer. 4. 390-392 (1996)

[Publications] Yamaji, T.: "Effect of clomipramine and verapamil on 5-HT-induced intracellular calcium changes in individual C6 glioma cells." Neuropsychobiol.33. 55-59 (1996)

[Publications] Minagawa, H.: "Psychiatric morbidity in terminally ill cancer patients." Cancer. 78. 1131-1137 (1996)

[Publications] Shimizu, M.: "Chronic amitriptyline exposure reduces 5-HT, receptor-mediated cyclic GMP formation in NG108-15 cells." Brain Res.741. 89-94 (1996)

[Publications] Kagaya, A.: "Differential regulation of intracellular signaling systems by sodium fluoride in rat glioma cells." J. Neurochem.66. 1483-1488 (1996)

[Publications] Fujikawa, T.: "Response of patients with major depression and silent cerebral infarction to antidepressant drug therapy, with emphasis on central nervous system adverse reactions." Stroke. 27. 2040-2042 (1996)

[Publications] Yamaji, T.: "Effects of carbamazepine and sodium valproate on 5-HT-induced calcium increase in individual C6 rat glioma cells." Neuropsychobiol.34. 22-25 (1996)

[Publications] Kugaya, A.: "Effect of interferon-α on DOI-induced wer-dog shakes in rats." J. Neural Transm.103. 947-955 (1996)

[Publications] 山脇成人: "サイコオンコロジー" 臨床腫瘍学. 1333-1363 (1996)

[Publications] 藤川徳美: "無症候性脳梗塞とうつ状態" Therapeutic Research. 17. 3061-3062 (1996)

[Publications] 加賀谷有行: "セロトニン2A受容体〜細胞内情報伝達系と感情障害" 脳と精神の医学. 7. 255-260 (1996)

[Publications] 岡本泰昌: "がん患者に関する精神医学的リエゾンカンファレンスの試み" 臨床精神医学. 25. 1443-1448 (1996)

[Publications] 加賀谷有行: "精神障害とCa^<2+>" Clinical Neuroscience. 14. 217-219 (1996)

[Publications] 岡本泰昌: "抗うつ薬抵抗性うつ病に対するリチウム追加投与の影響" 精神医学. 38. 405-409 (1996)

[Publications] 山脇成人: "免疫と脳のクロストーク-がん領域におけるPsychoimmunology-" 癌治療と宿主. 8. 31-38 (1996)

[Publications] 大久保善朗: "EICD-10による外来初診患者統計" 精神医学. 36. 505-509 (1996)

[Publications] Kaneko, K.: "The effects of single and repeated phencyclidine administration of ^<128>I-iomazenil binding in the rat brain." Neurochem. Int.54. 687-691 (1996)

[Publications] Arinami, T.: "Further association sdudy on dopamine D2 receptor variant S311C om schizophrenia and affective disorders." Am. J. Med. Gen. (Neuropsychiat. Gen.). 67. 133-138 (1996)

[Publications] 渋谷治男: "うつ病の神経科学" 最新の伝達物質-受容体の分子機構と関連神経疾患. 204-216 (1996)

[Publications] Kagaya, A.: "Plasma levels of cyclic GMP, immune parameters and depressive status during interferon therapy : A prospective study in Japan." Neuropsychobiol.(in press). (1997)

[Publications] Yamaji, T.: "Chronic treatment with antidepressants, verapamil or lithium inhibits the serotonin-induced intracellular calcium response in individual C6 rat glioma cells." Life Sci.(in press). (1997)

[Publications] Suzuki, E.: "Immobilization stress increases mRNA levels of interleukin-1 receptor antagonist in various rat brain." NeuroReport. (in press). (1997)

[Publications] Tokunaga, M.: "Alteration of benzodiazepine receptor binding potential in anxiety and somatoform disorders." Radiation Res. Assoc.(in press). (1997)

[Publications] 三国雅彦: "感情障害の受容体-細胞内情報伝達系機脳障害" 脳シクナルカスケードと精神疾患. (in press). (1997)

[Publications] 三国雅彦: "セロトニン受容体機能とうつ病" 感情障害-基礎と臨床-. (印刷中). (1997)

[Publications] Kato, N.: "Expression of c-fos mRNA after audiogenic seizure in adult rats with neonatal hypothyroidism." Mol. Brain Res.(in press). (1997)

[Publications] Ishida, N.: "Trimethyltin syndrome as a hippocampal degeneration model : temporal changes and neurochemical features of seizure susceptibility and learning impairment." Neurosci. (in press). (1997)

[Publications] Akaike, M.: "Abnormal behavior, spatial learning impairment and neuropeptides caused by temporary neonatal hypothyroidism." Thyroid and Brain. (in press). (1997)

[Publications] 網島浩一: "中枢神経系のソマトスタチン" 神経精神薬理. (印刷中). (1997)

[Publications] 網島浩一: "精神疾患における情動異常" 情動とホルモン. (印刷中). (1997)

[Publications] 加藤進昌: "基礎研究-神経ペプチド" 感情障害-基礎と臨床-. (印刷中). (1997)

[Publications] 石田展弥: "天然毒による中枢神経障害の基礎-その向精神作用と作用機序-" 神経精神薬理. (印刷中). (1997)

[Publications] 斎藤利和: "感情障害と細胞内情報伝達機構" 神経精神薬理. (印刷中). (1997)

[Publications] Kamata, H.: "Alterations of tubulin function caused by chronic antidepressant treatment in rat brain" Cell. Mol. Neurobiol.(in press). (1997)

[Publications] Ozawa, H.: "Cyclic AMP production and degeneration systems in postmortem cortex of depressed patients." J. Neural Transm.(in press). (1997)

山脇成人広島大学, 医学部, 教授 (40230601)

[Publications] 井上猛: "抗うつ薬に治療抵抗性のうつ病の実態とその治療戦略" 精神神経誌. 98. 329-342 (1996)