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1996 Fiscal Year Final Research Report Summary

Study for Clinical Application of Liver Transplantation

Research Project

Project/Area Number 06304035
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section総合
Research Field General surgery
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

DOHI Kiyohiko  Hiroshima University School of Medicine, Professor, 医学部, 教授 (90034024)

Co-Investigator(Kenkyū-buntansha) SUGIMACHI Keizo  Kyushu University, Faculty of Medcine, Professor, 医学部, 教授 (00038762)
MONDEN Morito  Osaka University Medical School, Professor, 医学部, 教授 (00127309)
TAKAGI Hiroshi  Nagoya University School of Medicine Professor, 医学部, 教授 (70154755)
ISONO Kaichi  Chiba University, School of Medicine, Professor, 医学部, 教授 (70009489)
FUKAO Katashi  University of Tsukuba, Institute of Clinical Medicine, Professor, 臨床医学系, 教授 (50091921)
Project Period (FY) 1994 – 1996
KeywordsLiver transplantation / Organ preservation / Non-heart-beating donor / Ischemia / reperfusion injury / Network for organ transplantation / Living-related liver transplantation / Immuno-regulation / Xenotransplantation
Research Abstract

1.Organ procurement and organ preservation : In the study regarding the relevance of donor nutritional state to graft liver function, it has been demonstrates that poor nutrition of donor caused the endotherial damage of liver sinusoids and results in the impediment to ability of mitochondrial ATP synthesis rates (Satomi and Tanaka). In the study regarding the organ harvesting, the effect of donor hypothermic therapy on graft function and the proper flow rate of initial flushing of graft organs were investigated (Taira). As an useful graft liver viability assays, hepatic protein synthesis rate assay using the graft tissues obtained by needle biopsy and graft effuent assay were developed (Isono and Sugimachi). For taking measures against ischemic damage of graft liver from non-heart beating donor, the novel methods such as the core cooling technique were investigated (Uchino, Satomi and Fukao).
2.Indication of liver transplantation : The objective criterions of indication and emergency l … More evel for liver transplantation were described for trial (0ta). For the development of proper registration program for liver transplantation recipients, the detailed follow-up-study of the registered recipientswas done (Sugimachi). A predictive equation for non-A,non-B acute hepatitis was developed for the criterion of indication for liver transplantation (Tanigawa).
3.Postoperative management for liver transplantation : The effect of graft liver size-matching on the postoperative graft function and the problem concerning FK506 immunosuppressive therapy in clinical living-related liver transplantation were researched (Yamaoka). As a novel development of immunosuppressive therapy, the drug-delivery modification for the conventional immunosuppressants (intraportal and intra-hepatic-arterial administration of FK506), the induction of immuno-hyporeactivity utilizing donor-antigen infusion (MMC-treated donor splenocyts infusion), the immuno-regulation by use of gene-therapy (CTLA-Ig gene transduction using adenovirus vector), the use of a novel immunosuppressant (Bactobolamine) were researched (Dohi, Monden, Takagi and Tomikawa).
4.Study of xenotransplantation : In order to develop the immuno-regulation method in concordant xenotransplantation, the effects of donor bone marrow utilization and the modification of donor antigen with MMC-treatment were investigated (Dohi and Monden). For the purpose of preventing hyperacute rejection in discordant xenotransplantation, human complement regulating genes were successfully transduced in pigs by use of retrovirus vector (Takagi). Less

  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] Tanaka A.: "Living realated liver transplantataion across ABO blood groups." Transplantation. 58. 548-553 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohta Y.: "Participation of donor adhesion molecules in islet xenograft rejection." Transplantation Proceedings. 27. 256-257 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohdan Hideki: "Diagnostic value of near-infraredspectroscopy for monitoring the rejection response following rat liver transplantation." Transplantation Proceedings.27. 516-517 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] OzaKi M.: "The in vivo cytoprotection of ascorbic acid against ischemia/reoxygenation injury of rat liver." Arch.Biochm.Biophys.318. 439-445 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ueda M.: "A proposal of FK506 optimal dosing in living-related liver transplantations." Transplantation. 60. 258-264 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikai I.: "Operation for larger recipients in living related liver transplantation." Transplantation Proceedings. 28. 56-58 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsukamoto Shigeki: "Procurement of Liver Grafts by and Artificial Heart Lung Machine Using Leykocyte-Depleted Washed Red Blood Cells in Non-Heart-Beating Donors." Transplantation Proceedings. 28. 197-200 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Degawa H.: "Blocking of ICAM-1 and LFA-1 in rat liver transplantaion." Transplantation Proceedings. 28. 1362-1363 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yano Kenji: "Orthotopic Liver Transplantation for Primary Hepatic Cancer in Rats." Transplantation Proceedings. 28. 1682-1683 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Isai H.: "Calcium mobilization in porcine opthotopic liver transplantation." Transplantation Proceedings. 28. 1780-1781 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kamachi H.: "Study of liver function in a graft suffering from warm ischemia in porcine liver transplantation." Transplantation Proceedings. 28. 1789-1791 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakamoto K.: "Utilization of Organ Preservation Machine as an EX Vivo Swine Liver Perfusion System With Human Whole Blood at 37°C." Transplantation Proceedings. 28. 1919-1920 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morimoto T.: "Guideline for donor selection and an overview of the donor operation in living related liver transplantation." Transplant International. 9. 208-213 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Wakiyama S.: "Assesment of hepatic graft injury by graft effluent in rodents : N-acetyl-β-glucosaminidase and type III procollagen peptide." Transplant International. 9. 359-363 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tashiro Hirotaka: "Assesment of Microchimerism in Rat Liver Transplantaiton by Polymerase Chain Reaction." Hepatology. 23. 828-834 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Marubayashi Seiji: "Therapeutic Modulation of Free Radical-Medicated Reperfusion Injury of the Liver and Its Surgical Implicaions." Surgery Today. 26. 573-580 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 野口和典: "B型肝炎ウィルスによる肝障害に対する肝移植:現況と問題点。" 肝胆膵. 33. 43-49 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikoma A.: "Use of heat-insulating material for prevention of severe recipient hypothermia during multivisceral transplantation in pigs." Transplantation Proceedings. 28. 2644-2645 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanaka A.: "Living related liver transplantation across ABO blood groups." Transplantation. 58. 548-553 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohta Y.: "Participation of donor sdhesion molecules in islet xenograft rejection." Transplantation Proceedings. 27. 256-257 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohdan Hideki: "Diagnostic value of near-infrared spectroscopy for monitoring the rejection response following rat liver transplantation." Transplantation Proceedings. 27. 516-617 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ozaki M.: "The in vivo cytoprotection of ascorbic acid against ischemia/reoxygenation injury of rat liver." Arch. Biochm, Biophys.318. 329-445 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ueda M.: "A proposal of FK506 optimal dosing in living-related liver transplantations." Transplantation. 60. 258-264 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikai I.: "Operation for larger recipients in living related liver transplantation." Transplantation Proceedings. 28. 56-58 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsukamoto Shigeki: "Procurement of Liver Grafts by and Artificial Heart Lung Machine Using Leycocyte-Depleted Washed Red blood Cells in Non-Heart-Beating Donors." Transplantation Proceedings. 28. 197-200 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Degawa H.: "Blocking of ICAM-1 and LFA-1 in rat liver transplantaion." Transplantation Proceedings. 28. 1362-1363 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yano Kenji: "Orthotopic Liver Transplantation for Primary Hepatic Cancer in Rats." Transplantation Proceedings. 28. 1682-1683 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Isai H.: "Calcium mobilization if porcine opthotopic liver transplantation." Transplantation Proceedings. 28. 1780-1781 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kamachi H.: "Study of liver function in a graft suffering from warm ischemia in porcine liver transplantaion." Transplantation Proceedings. 28. 1789-1791 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakamoto K.: "Utilization of Organ Pressrvation Machine as an EX Vivo Swine Liver Perfusion System With Human Whole Blood at 30゚C." Transplantation Proceedings. 28. 1919-1920 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morimoto T.: "Guideline for donor selection and an overview of the donor operation in living related liver transplantation." Transplant Int.9. 208-213 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wakiyama S.: "Assesment of hepatic graft injury by graft effluent in rodents : N-acetyl-beta-glucosamindase and type III procollagen peptide." Transplant Int.9. 359-363 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tashiro Hirotaka.: "Assesment of Microchimerism in Rat Liver Transplantaiton by Polymerase Chain Reaction." Hepatology. 23. 828-834 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Marubayashi Seiji.: "Therapeutic Modulation of Free Radical-Medicated Reperfusion Injury of the Liver and Its Surgical Implicaions." Surgery Today. 26. 573-580 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noguchi K.: "Actual problems in liver transplantation of patients with hepatitis B Virus infection." Hepato-Biliary-Pancreatic Diseases. 33. 43-49 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikoma A.: "Use of heat-insulating material for prevention of severe recipinet hypothermia during multivisceral transplantation in pigs." Transplantation Proceedings. 28. 2644-2645 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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