• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1995 Fiscal Year Final Research Report Summary

Structure and function of macrophage scavenger receptors

Research Project

Project/Area Number 06454334
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 内分泌・代謝学
Research InstitutionUniversity of Tokyo

Principal Investigator

KODAMA Tatsuhiko  The Third Department of Intermal Medicine, University of Tokyo, 医学部(病), 助手 (90170266)

Co-Investigator(Kenkyū-buntansha) WADA Yoichiro  3rd Dept.Int.Med, Univ.Tokyo, 医学部(病), 医員
NAKAJIMA Atsushi  3rd Dept.Int.Med, Univ.Tokyo, 医学部(病), 医員
MATSUHASHI Nobuyuki  3rd Dept.Int.Med, Univ.Tokyo, 医学部(病), 助手 (10221590)
Project Period (FY) 1994 – 1995
Keywordsmacrophage / scavenger receptor / atherosclerosis / lipoprotein / host defense / mouse qenetics / endocytosis / adhesion molecule
Research Abstract

Macrophage scavenger receptor is a trimeric membrane glycoprotein with a single transmembrane domain. MSR mediates a) wide range of ligand binding, b) ligand internalization, c) acid dependent ligand dissociation d) cell adhesion and e) cell to cell interactiion. The mechanism by which scavenger receptor is regulated the inteynalization, recycling, and adhesion function remains an open question. Several possible explanation may exist. When a ligand binds to domain 5, the intemalization may occur, and on the other hand binding a ligand or antibody to domain 4 may results in the adhesion function or inhibition of adhesion. The other possibility is as follows. if the ligand is free in liguid, it will be internalized. If the ligand is too big for endocytosis, the binding of many MSR molecules may enhance the phagocytosis, and if the ligand is fixed on the extracellular matrix, adhesion may occur If the ligand is on the cell surface, MSR may mediate cell to cell interaction. A further understanding of MSR will provide new insight into various macrophage-mediated physiological processes, and also macrophage-related pathological processes, including atherosclerosis.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Matoh. M, Kodama, T.et al: "Involvement of specific macrophage lineage cells surrounding arterioles in barrier and scavenger function in brain coriex." Proc. Natl. Acad. SciUSA.(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Terauchi. Y, Kodama. T et al.: "Pancreatic-B-cell-specific targeted disruption of glucokinase gene." J Biol. Chem.270. 30253-30256 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimakawa. T. Kodama. T et al.: "Determination of mRNA levels of cholesterol biosynthesis enzymes and LDL receptor using ribonuclease protection assay." J. Lipid Res.36. 1919-1924 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kume. S, et al.: "Immunohistochemical and ultrastructural detection of advanced glycation end products in atherosclerotic lesions of human aortawith a novel specific monoclonal antibody." Am. J. Patol.654-667 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Araki, N. et al.: "Macrophage scavenger receptor mediates the endocytic uptake and degradation of advanced glycation end products of the maillard reaction" Eur. J. Biochem. 230. 408-415 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Wada. Y, et al.: "Structure and function of macrophage scavenger receptors" Ann. N. Y. Acad. Sci.748. 226-239 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mato, M., Ookawara, S., Sakamoto, A., Aikawa, E., Ogawa, T., Mitsuhashi, U., Masuzawa, T., Suzuki, H., Honda, M., Yazaki, Y., Watanabe, E., Luoma, J.Yla-Herttuala, S., Fraser, I., Gordon, S.and Kodama, T.: "Involvement of specific macrophage lineage cells surrounding arterioles in barrier and scavenger function in brain cortex." Proc.Natl.Acad.SciUSA. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Terauchi Y,Sakura H,Yasuda K,Iwamoto K,Takahashi N,Ito K,Kasai H,Suzuki H,Ueda O,Kamada N,Jishage K.Komeda K,Noda M,Kanazawa Y,Taniguchi S Miwa I,Akanuma Y,Kodama T,Yazaki Y and Kadowaki T.: "Pancreatic B-cell-specitic targeted disruption of glucokinase gene" J Biol.Chem. 270. 30253-6 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimokawa, T., Kawabe, Y., Honda, M., Yazaki, Y., Itakura, Hand Kodama, T.: "Determination of mRNA levels of cholesterol biosynthesis enzymes and LDL receptor using ribonuclease protection assay" J.Lipid Res. (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kume, S., Takeya, T.Mori, T., Araki, N., Suzuki, H., Horiuchi, S., Kodama, T., Miyauchi, Y.and Takahashi, K: "Immunohistochemical and ultrastructural detection of advanced glyc ation end products in atherosclerotic lesions of human aorta with a novel specific monodonal antibody" Am.J.Patol. 654-667 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Araki, N., Higashi, T., Mori, T., Shibayama, R., Kawabe, Y., Kodama, T., Takahashi, K., Shichiri, M., and Horiuchi, S: "Macrophage scavenger receptor mediates the endocytic uptake and degradation of advanced glycation end products of the maillard reaction" Eur.J.Biochem. 230. 408-415 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wada, Y.Doi, T.Kodama, T.et al: "Structure and function of macrophae scavenger receptors" Ann.N,Y,Acad, Sci. 748. 226-239 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1997-03-04  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi