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1995 Fiscal Year Final Research Report Summary

USEFULNESS OF LIQUID VENTILATION BY PERFLUOROCARBON IN EXEPIMENTAL MODEL OF ACUTELUNG INJURY

Research Project

Project/Area Number 06670606
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionSHINSHU UNIVERSITY

Principal Investigator

KUBO Keishi  SHINSHU UNIVERSITY SCHOOL OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 講師 (80143965)

Co-Investigator(Kenkyū-buntansha) KOIZUMI Tomonobu  SHISHU UNIVERSITY HOSPITAL,ASSISTANT, 医学部附属病院, 助手
SAKAI Akio  SHINSHU UNIVERSITY SCHOOL OF MEDICINE RESARCH CENTER ON AGING AND ADAPTATION,ASS, 医学部附属加齢適応研究センター, 助教授 (70020758)
FUJIMOTO Keisaku  SHINSHU UNIVERSITY HOSPITAL,ASSISTANT, 医学部附属病院, 助手 (70242691)
HONDA Takayuki  SHINSHU UNIVERSITY SCHOOL OF MEDICINE,ASSISTANT, 医学部, 助手 (80238815)
KOBAYASHI Toshio  SHINSHU UNIVERSITY HOSPITAL,ASSISTANT PROFESSOR, 医学部附属病院, 講師 (80020775)
Project Period (FY) 1994 – 1995
KeywordsEndotoxin-induced lung injury / Anesthetized sheep / Perfluorocarbon / Liquid ventilation / Lung lymph flow
Research Abstract

We investigated the effects of liquid ventilation using perfluorocarbon (Liqui Vent ; LV) on acute lung injury induced by endotoxemia in anesthetized sheep weighing 10-15 kg. We had previously prepared the lung lymph fistula and hemodynamic monitering. E.coli endotoxin of 10 ug/kg was infused i. v. 1 hr after LV instillation into the lungs through the trachea tube. Anesthesia was continued by intravenous pentobarbital sodium of 25 mg/kg and panclonium of 0.1 mg/kg.
Measurements : Pulmonary hemodynamics, systemic hemodynamics, lung lymph balance, arterial blood gas analysis, peripheral leukocyte counts
Experimental protocol :
(1)Anesthesia condition ; Fio2 0.5, TV 12ml/kg, RR 30/min, PEEP 5cmH2O LV ; 10 mi/kg
(2)Anesthesia condition ; FiO2 1.0, TV 12ml/kg, RR 30/min, PEEP 5cmH2O LV ; 20 ml/kg
In each experiment sheep were divided into the endotoxin alone and the endotoxin plus LV group.
Results are as follows. In experiment (1) , pulmonary hypertension, increased lung lymph flow, hypoxemia and peripheral leukopenia induced by endotoxin were partially suppressed by pretreatment of LV instillation into the lungs. However in experiment (2) these changes induced by endotoxin were not suppressed by LV instillation.
The differences of FiO2 and the volume of LV might produce the different results between experimental (1) and (2) . We need further studies to see the effects of the liquid ventilation by perfluorocarbon on acute lung injury.

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Kubo,K.et al: "Cytokines in bronchoalveolar lavage fluidin patients with high-altitude pulmonary edewa at moderate altitude in Japan" Thorax. (発表予定).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kubo,K.et al: "Brouchoalveolar lavage fluid findings in patients with chrovic hepatitis C" Thorax. (発表予定).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujimoto,K.et al: "Eosinophil activation in patients with pulmorary fibrosis" Chest. 108. 48-54 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujimoto,K.et al: "Neutrophil elastase inhibitor reducos asthmatic respouses in allergic sheep" Respir Physiol. 100. 91-100 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ge R-L,et al: "Comparisons of oxygen trans port between Tibetan and Han residents at maderate altitude" Wilderness Environ Med. 6. 391-400 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 久保,恵嗣: "動物モデルにおける肺損傷" The Lung Perspectives. 3. 153-157 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 久保,恵嗣 他: "急性肺障害の基礎と臨床 肺障害とchemical mediators" 日本胸部疾患学会雑誌. (発表予定).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 花岡正幸 他: "高地肺水腫/特発性間質性肺炎とその周辺疾患" 河合健編集:山之内製薬KK, 488 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林俊夫,久保恵嗣: "血液ガス,わかりやすい基礎知識と臨床応用" 山村一,河合忠,塚本玲三編集;医学書院, 277 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] KOIZUMI,T et al: "Pulmonary Circulation Research 1994" 93 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kubo, K.et al.: "Cytokines in bronchoalveolar lavage fluid in patients with high-altitude pulmonary edema at moderate altitude in Japan" Thorax. (In press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kubo, K.et al.: "Bronchoal veolar lavage fluid findings in patients with chronic hepatitis C" Thorax. (In press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujimoto, K.et al.: "Eosinophil activation in patients with pulmonary fibrosis." Chest. 108. 48-54 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujimoto, K.et al.: "Neutrohil elastase inhibitor reduces asthamtic response in allergic sheep" Respir Physiol. 100. 91-100 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ge, R-L.et al.: "Comparison of oxygen transport between Tibetan and Han residents at moderate altitude." Wilderness Environ Med. 6. 391-400 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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