1995 Fiscal Year Final Research Report Summary

Inhibition of cytokine production and suppression of graft rejection by macrophage colony stimulating factor.

Research Project

Project/Area Number	06671206
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	General surgery
Research Institution	Okayama University
Principal Investigator	NAOMOTO Yoshio Okayama University, Medical School, First Department of Surgery, Instructor, 医学部・附属病院, 助手 (00237190)
Co-Investigator(Kenkyū-buntansha)	ORITA Kunzo Okayama University, Medical School, First Department of Surgery, Professor, 医学部, 教授 (20033053)
Project Period (FY)	1994 – 1995
Keywords	tumor necrosis factor / macrophage colony stimulating factor / rejection / organ transplantation / inflammation / sepsis / skin graft
Research Abstract	Macrophage-colony stimulating factor (M-CSF) was discovered as a factor stimulating production, muturation and function of monocytes. Subsequent investigations have revealed that M-CSF has a variety of functions such as stimulation of neutrophil and platelet production, antifungal activity, tumoricidal effect, induction of villous cell differentiation, decrease in cholesterol, suppression of arteriosclerosis and differentiation and maturation of osteoclasts. However, many points of the mechanism of M-CSF actions remain unclear. Our investigations have demonstrated that M-CSF administration markedly inhibited cytokine production in response to stimulation with lipopolysaccharide (LPS) in mice presensitized by BCG.