1995 Fiscal Year Final Research Report Summary

Study of appropriate momentum to prevent disuse muscle atrophy

Research Project

Project/Area Number	06671448
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	Orthopaedic surgery
Research Institution	Kanazawa University
Principal Investigator	HAIDA Nobuhide Kanazawa University, School of Medicine, Professor, 医学部, 教授 (00135089)
Project Period (FY)	1994 – 1995
Keywords	Muscle atrophy / Physical exercise / Cross sectional area / Ca^<++>-activated neutral protease / Lysosomal enzyme / Neuro muscular junction
Research Abstract	This study was undertaken to determine the ameliorative effect of physical exercise program on histological and biochemical alterations of rat soleus muscle by hind limb suspension. Weight bearing, isotonic and isometric contraction were carried out for the purpose of preventing the muscle atrophy on the hind limb suspended rats. Cross sectional area of muscle fiber in weight bearing during suspended period was most decreased. but no atrophy was showed in the muscle of isometric contraction. Frequency of macrophage was appeared extently in muscle of weight bearing and isometric contraction, however that was remarkably much in isotonic contraction. Also even regressive changes of the neuro muscular junctions are trifling in isometric contraction. Therefore it is thought that isometric contraction is optimum as a methed of the prevention of atrophy.