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1995 Fiscal Year Final Research Report Summary

Experimental Studies on mechanism underlying noise-induced Rearing disorder.

Research Project

Project/Area Number 06671745
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionUniversity of Occupational and Environmental Health

Principal Investigator

YOSHIDA Masafumi  University of Occupational and Environmental Health Medical School, Otorhinolaryngology, Asociate Professor., 医学部, 助教授 (00182783)

Project Period (FY) 1994 – 1995
KeywordsNoise exposure / Salicylate toxicity / Hearing disorder / Cochlear microphonics / Otoacoustic emission / 2f_1-f_2 distortion product
Research Abstract

In the first year, cochlear microphonics (CM) in response to two tone stimuli as well as compound action potential (CAP) of the acoustic nerve were measured before and after exposure to 4kHz pure tone at 100dB SPL for 10min. The output of 2f1-f2 distortion product in the CM (CM-DP) were markedly reduced immediately after the exposure and then recovered gradually. The reduction and recovery in CM-DPs closely paralleled with those in the CAP.This may indicate that the affection of the outer hair cell (OHC) function plays an important role in developing the noise induced temporary threshold shift. The following study with administration of salicylate, which was known to interfere the electro-mechanical transduction (EMT) of OHCs, reveled the different alterations of the CM-DPs from those with sound exposure. From these results it is postulated that acoustic overstimulation affects the mechano-electrical transduction (MET) of OHC.
In the following year, combined effects of loud sound and salicylate were studied. The effects were altered by changing the order in which the two agents were applied. The existing sound-induced damage attenuated the additional ototoxicity of salicylate, whereas attenuation did not occur when salicylate administration preceded sound exposure. From these results it is postulated that the MET holds dominant position over EMT in the cochlear transduction mechanism.
Spontaneous electrical oscillations (AC potentials) were accidentally recorded from the cochlea of several animals without any exposure to sound or drugs. Close observations in the properties of the AC potentials indicated that the potentials were generated by the active mechanical vibration system at the area on the basilar membrane where the characteristic frequency corresponded to that of the potential.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 吉田雅文: "CM電位2f_1-f_2歪成分に及ぼす音響暴露の影響" 日本耳鼻咽喉科学会会報. 97. 680-683 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M. Yoshida: "Effects of Acoustic Overstimulation on Cochlear Evoked Potential" Eur Arch Otorhinolaryngology. 251. S61-S64 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M. Yoshida: "Effects of Acoustic Overstimulation on 2f_1-f_2 Distortion Product in the Cochlear Microphonics" Hearing Research. 82. 59-64 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 吉田雅文: "モルモット蝸牛内自発交流電位の外部音による抑圧" 日本耳鼻咽喉科学会会報. 99. 327-332 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M. Yoshida: "Physiological Basis of Occupational Health, E d. by K. Shiraki" SPB Academic Publishing, Amsterdam, The Netherlands, (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Yoshida: "Effects of loud noise exposure on 2f1-f2 distortion product in the CM." J of Otolaryngol Japan. Vol 97. 680-683 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Yoshida: "Effects of Acoustic Overstimulation on Cochlear Evoked Potential." Eur Arch Otorhinolaryngology. Vol.251. S61-64 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Yoshida: "Effects of Acoustic Overstimulation on 2f1-f2 Distortion product in the Cochlear Microphonics." Hearing Research. Vol 82. 59-64 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Yoshida: "Suppression of Spontaneous AC Potentials in Guines Pig Cochlea by External Tones." J of Otolaryngol Japan. Vol 99. 327-332 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Yoshida: "Mechanisms underlying noise induced temporary threshold shift in hearing in "Physiological basis of Occupational Health" edited by K.Shiraki and MK.Yousef" APB Academic Publishing, Amsterdam, The Netherlands.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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