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1995 Fiscal Year Final Research Report Summary

The investigation of side dffects to the fingertips caused by dental adhesive monomers.

Research Project

Project/Area Number 06671926
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionShowa University

Principal Investigator

MANABE Atsufumi  Showa University, School of Dentistry, Assistant Professor, 歯学部, 講師 (40199906)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Sadao  Showa University, School of Medicine, Assistant Professor, 医学部, 講師 (00054007)
YOSHIDA Takemi  Showa University, School of Pharmaceutical Sciences, Professor, 薬学部, 教授 (20138415)
IIJIMA Masafumi  Showa University, School of Medicine, Professor, 医学部, 教授 (20010449)
Project Period (FY) 1994 – 1995
Keywordsdelayd Allergy / contact dermatitis / HEMA / dentin primer / Maximization Test
Research Abstract

To obtain complete marginal adaptation between the dentin and the composite, dentin primers are used as adhesives. However, even if the dentist tries to protect his or her fingers from the methacrylates by wearing rubber gloves, rubefaction, tumefaction, blebs and pruritus often occur on the fingertips. The purpose of this study was to examine whether these primers cause contact dermatitis and, using a maximization test, to determine the optimum concentrations of 20-HEMA, GM and methacrylic acid (MA) for sensitization and challenge in guinea pigs. We also observed the development of contact dermatitis on human brachia in a closed-patch test. A sensitizing concentration of 0.2% HEMA resulted in the development of strong rubefaction and several vesiculopapules in response to the challenge. A sensitizing concentration of 0.5% GM produced strong rubefaction at 24 hours.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] K.KATSUNO: "A delayed hypersensitivity reaction to dentine primer in the guinea-pig" JOURNAL of Dentistry. 23. 295-299 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.NUMAZAWA: "Involvement of Na^+,K^+-ATPase inhivition in K562 cell Differentiation induced by bufalin" JOURNAL of Cellular Physiology. 160. 113-120 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.OKAZAKI: "Correlation between Plasma Fibrinogen and Serum Lipids in Rats with Hyperlipidemia Indneed by Cholesterol Free-High Fructose or Hygh Cholesterol Diet" J.Nutr.Sci.Vitaminol. 40. 479-489 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.KATSUNO: "A delayd hypersensitivity reaction to dentine primer in the guinea-pig" JOURNAL of dentistry. 23. 295-299 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.NUMAZAWA: "Invo1vement of Na^+, K^+-ATPase inhivition in K562 cell Differentiation induced by bufalin" JOURNAL of Cellular Physiology. 160. 113-120 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.OKAZAKI: "Correlation between Plasma Fibrinogen and Serum Lipids in Rats with Hyperlipidemia Indneed by Cholesterol Free-High Fructose or Hygh Cholesterol Diet" J.Nutr.Sci.Vitaminol. 40. 479-489 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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