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1995 Fiscal Year Final Research Report Summary

Stduy on residual fluoride materials in human body by fluoride analysis

Research Project

Project/Area Number 06672046
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 矯正・小児・社会系歯学
Research InstitutionShiga University of Medical Science

Principal Investigator

KIMURA Takahide  Shiga University of Medical Science Deartment of Medicine Associate Professor, 医学部, 助教授 (70167378)

Co-Investigator(Kenkyū-buntansha) SHIRAISHI Tsuyoshi  The first Biwako School Dentist, 歯科医師
YAMAMOTO Gaku  Shiga University of Medical Science Deartment of medicine Lecturer, 医学部, 講師 (40230544)
Project Period (FY) 1994 – 1995
KeywordsFluoride Analysis / Low Temperature Oxygen Plasma Ashing / Perfluorooctanoic Acid / Flomoxef Sodium / Alubmin / Erythrocyte / Bone Matrix Gelatin / Bone Morphogenetic Protein
Research Abstract

The distribution of perfluorooctanoic acid (PFOA) and flomoxef sodium (FMOX) in various components of blood was investigated by taking fluoride incorporated into these components as an indicator of these chemicals. Fluoride was measured by the low temperature oxygen ashing-gas chromatography method (LOPA-GC method). The time courses of the binding of PFOA and FMOX to the components of blood system were considerably different from those of binding to albumin and erythrocytes in a simple system composed only of albumin and erythrocytes. In contrast to the fact that FMOX bound to albumin in the cell suspension was easily released. PFOA was very slowly released from albumin. The release of both PFOA and FMOX from erythrocytes was little noticeable. It was shown that the movement o organic fluorine compounds in the body can be traced by the fluoride analysis, and that the movement of PFOA and FMOX can be interpreted by the velocity differece between their bindings to albumin and erythrocytes.
It is well known that bone morphogenetic protein (BMP) introduces osteogenesis. However, formed bones are frangible bones with wide cavity of bone marrow. That fluoride accelerates the osteogenesis and calcification is also well known. Thus, bone matrix gelatin (BMG) was transplanted in abdominal muscles of rats and fluoride was applied via drinking water or localized application. Then, effect of fluoride application on new bone formation was observed. As results, it was shown that fluoride application via drinking water accelerates Ca incorporation into new bones, activation of ALP-ase activity and calcification more.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 白石 剛: "パ-フルオロオクタン酸およびフロモキセフナトリウムの血液中における分配平衡のフッ素分析法による研究" 滋賀医科大学雑誌. 10. 87-97 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] F. Hayakawa: "The Cooperative Effect of Tea Catechins with Fluoride and Aluminium lons on Acid Resistance of Hydroxyapatite" J. Dent. Health. 45. 184-189 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] G. Yamamoto: "Behavior of lonic,lonizable and Organic Fluorides in Whole Blood and Serum after Oral Administration of Sodium Fluoride and p-Fluorobenzoic Acid in Rat" Environmental Sci.2. 195-200 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Shiraishi: "Study on distribution and equilibrium of perfluorooctanoic acid and flomoxef sodium in blood by fluoride analysis" J Shiga Univ Med Sci. 10. 87-97 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] F.Hayakawa: "The Cooperative Effect of Tea Catechins with Fluoride and Aluminium lons on Acid Resistance of Hydroxyapatite" J Dent Health. 45. 184-189 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] G.Yamamoto: "Behavior of lonic, lonizable and Organic Fluorides in Whole Blood and Serum after Oral Administration of Sodium Fluoride and p-Fluorobenzoic Acid in Rat" Environmental Sci 2. 4. 195-200 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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