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1997 Fiscal Year Final Research Report Summary

Interpretation of the mechanism of cardiovascular deconditioning induced by the long-term exposure to microgravity.

Research Project

Project/Area Number 07045048
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionUniversity-to-University Cooperative Research
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionNagoya University

Principal Investigator

MANO Tadaaki  Nagoya University, Research Institute of Environmental Medicine, Professor, 環境医学研究所, 教授 (30023659)

Co-Investigator(Kenkyū-buntansha) EGOROV Anato  ロシア厚生省医学生物学研究所, 教授
KOZLOVSKAYA イネッサ  ロシア厚生省医学生物学研究所, 教授
GRIGOIEVV An  ロシア厚生省医学生物学研究所, 所長
SUGIYAMA Yoshiki  Nagoya University, Research Institute of Environmental Medicine, Assistant Profe, 環境医学研究所, 助手 (50240809)
IWASE Satoshi  Nagoya University, Research Institute of Environmental Medicine, Associate Profe, 環境医学研究所, 助教授 (90184879)
GRIGORIEV Anatoly  Institute of Biomedical Problems, Ministry of Health of Russia, Professor
KOZLOVSKAYA Inessa B.  Institute of Biomedical Problems, Ministry of Health of Russia, Professor
EVOROV Anatolya D.  Institute of Biomedical Problems, Ministry of Health of Russia, Professor
Project Period (FY) 1995 – 1997
Keywordsmuscle sympathetic nerve activity / cardiovascular deconditioning / microgravity / bed rest / dry immersion / static exerc / orthostatic stress
Research Abstract

On return to the earth sfter spaceflight, cardiovascular deconditioning, including fall in blood pressure and sometimes syncope, is known to occur. Variable autonomic symptons were reported during spaceflight. However, the effect of microgravity on autonomic function is almostly unclear. We performed 3 days of dry immersion (DI) as the stimulation of short duration microgravity and 120 days of 6-degree head-down bed rest (BR) as that of long duration weightlessness.After 3 days of DI,resting muscle sympathetic nerve activity (MSNA) recorded with use of microneurography, and resting cardiac sympathetic nerve activity indicated by heart rate variability were higher than those before DI,and resting cardiac vagal activity was lower than that before DI.Systolic and diastolic blood pressure werre similar to that before DI.Increasing response of MSNA,cardiac sympathetic nerve activity and heart rate to orthostatic stress, and decreasing response of cardiac vagal activity to it were maintained. After 12 _o days of BR,resting MSNA and heart rate were higher than those before BR.Systolic and diastolic blood pressure werre similar to that before BR.Rises in MSNA and heart rate in response to orthostatic stress were maintained. Systolic and diastolic blood pressure resposes to it did not change. However, increasing response in MSNA to static leg exercise (30% maximal voluntary contraction) was declined and rise in mean blood pressure to it disappeared. 3 days of the exposure to microgravity and 120 days of it increased MSNA to almost same degree. From the assessment of changes in MSNA,heart rate (variability) and blood pressure, both of them did not effect autonomic responses to orthostatic stress, but the latter declined the MSNA response.

  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Iwase S, Sugiyama Y, Miwa T, Kouno M, Mano T: "3日間のdry immersionがヒトの心循環機能に及ぼす影響(1)" 環境医学研究所年報. 47. 38-42 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miwa T, Sugiyama Y, Iwase S, Kouno M, Mano T: "3日間のdry immersionがヒトの心循環機能に及ぼす影響(2)" 環境医学研究所年報. 47. 43-46 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugiyama Y, Miwa T, Kouno M, Iwase S, Mano T: "3日間のdry immersionがヒトの心循環機能に及ぼす影響(3)" 環境医学研究所年報. 47. 47-50 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iwase S,Mano T,Sugenoya J,Sugiyama Y,Matsukawa T: "Microneurographic study on sympathetic control of sweating and skin blood flow" Biomedical Thermology. 13. 460-464 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] 1wase S,Mano T: "Skin sympathetic nerve activity and sweating" Neurological Medicine. 44. 121-130 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwase S,Ikeda T,Kitazawa H,Hakusui S,Sugenoya J,Mano T: "Altered response in cutaneous sympathetic outflow to mental and thermal stimuli in primary palmoplantar hyperhidrosis" Journal of the Autonomic Nervous System. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwase S,Kitazawa H,Cuj J,Sawasaki N,Mano T: "Differentiation of skin sympathetic nerve activity to sudomotor and vasoconstrictor nerve components" EIectroencephalography and clinical Neurophysiology. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwase S,Mano T,Sugenoya J,Sugiyama Y,Matsukawa T,Okamoto T,Yamamoto K: Microneurographic study on sympathetic control of sweating and skin blood flow, In : Mabuchi K,Mizushina S,Harrison B eds, Advanced Techniques and Clinical Applications in Biomedical Thermology. Harwood Academic Publishers, Chur, Switzerlnd, 147-162 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwase S,Okamoto T,Mano T,sugenoya J,sugiyama Y: Thermal dependency of sympathetic outflow to the skin. In : Nagasaka T,Milton AS,eds, Body Temperature and Metabolism. International Press Editing Center lncorporation, Tokyo, 137-140 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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