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1999 Fiscal Year Final Research Report Summary

Functional Development of Neural Circuits

Research Project

Project/Area Number 07279102
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionOsaka University Graduate School of Medicine

Principal Investigator

TSUMOTO Tadaharu  Osaka University Graduate School of Medicine, Professor, 医学系研究科, 教授 (50028619)

Co-Investigator(Kenkyū-buntansha) YOSHIOKA Toru  Waseda University School of Human Sciences. Professor, 人間科学部, 教授 (70046027)
OBATA Kunihiro  Okazaki NatI. Res. Inst., National Inst. For Physiological Science, Professor, 生理学研究所, 教授 (60013976)
MURAKAMI Fujio  Osaka University Graduate School of Engineering Science, Professor, 基礎工学研究科, 教授 (20089882)
IKENAKA Kazuhiro  Okazaki Nati. Res. Inst., National Inst. For Physiological Science. Professor, 生理学研究所, 教授 (00144527)
KAWAI Nobufumi  Jichi Medical School, Professor, 医学部, 教授 (00073065)
Project Period (FY) 1995 – 1998
KeywordsBrain / Neural Circuits / Development / Neuron / Synapse / Differentiation / Growth / Plasticity
Research Abstract

This project addressed a question of how neural circuits are formed and functionally developed so as to execute the higher brain function. To elucidate mechanisms underlying the formation and functional development of neural circuits in the brain, we took multidisciplinary approaches in this project. Thus, a close collaboration among researchers with different methodologies was essential for success of this project. After such a collaboration among members of this research project, we succeeded in obtaining many excellent results which were published in top-rank international journals. In this fiscal year we have edited a report of their achievements including a list of their publications. This report has been sent to researchers who are working in related fields and the members of this research project.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Hata, Y., Ohsima, M., Ichisaka, S., Wakita, M. et al.: "Brain-derived neurotrophic factor expands ocular dominance columns in visual cortex in monoculary deprived and nondeprived kittens but does not in adult cats"J. Neuroscience. 20(RC57). 1-5 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kumura, E., Kimura, F., Taniguchi, N. and Tsumoto, T.: "Brain-derived neurotrophic factor blocks long-term depression in solitary neurones cultured from rat visual cortex"J. Physiology (London). 524. 195-204 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hata, Y., Tsumoto, T. and Stryker, M.P.: "Selective pruning of active afferents when cat visual cortex is pharmacologically inhibited"Neuron. 22. 375-381 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shirasaki, R., Katsumata, R. and Murakami, F.: "Change in chemoattractant responsiveness of developing axons at an intermediate target"Science. 279. 105-107 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kojima, N., Ishibashi, H., Obata, K. and Kandel, E.R.: "Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice"Learning & Memory. 5. 429-445 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Allen, C., Jiang, Z., Teshima, K., Darland, T., Ikeda, M. et al.: "Orphanin-FQ (OFQ) modulates the activity of suprachiasmatic nucleus neurons"J. Neuroscience. 19. 2152-2160 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hata, Y., Ohshima, M., Ichisaka, S., Wakita, M. et al.: "Brain-derived neurotrophic factor expands ocular dominance columuns in visual cortex in monocularly deprived and nondeprived kittens but does not in adult cats"J. Neuroscience. 20 (RC57). 1-5 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kumura, E., Kimura, F., Taniguchi, N. and Tsumoto, T.: "Brain-derived neurotrophic factor blocks long-term depression in solitary neurones cultured from rat visual cortex"J. Physiology (London). 524. 195-204 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hata, Y., Tsumoto, T. and Stryker, M. P.: "Selective pruning of active afferents when cat visual cortex is pharmacologically inhibited"Neuron. 22. 375-381 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shirasaki, R., Katsumata, R. and Murakami, F.: "Change in chemoattractant responsiveness of developing axons at an intermediate target"Science. 279. 105-107 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kojima, N., Ishibashi, H., Obata, K. and Kandel, E. R.: "Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice"Learning & Memory. 5. 429-445 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Allen, C. N., Jiang, Z., Teshima, K., Darland, T., Ikeda, M. et al.: "Orphanin-FQ (OFQ) modulates the activity of suprachiasmatic nucleus neurons"J. Neuroscience. 19. 2152-2160 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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